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Cited by 434

The DOI matches its Crossref record; 238 of the 238 references it cites were found in a registry or an index.

Zinc: health effects and research priorities for the 1990s.

Open access
Walsh, C T, Sandstead, H H, Prasad, A S, Newberne, P M, Fraker, P J·1994·Environmental Health Perspectives
DOI 10.1289/ehp.941025
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Abstract

This review critically summarizes the literature on the spectrum of health effects of zinc status, ranging from symptoms of zinc deficiency to excess exposure. Studies on zinc intake are reviewed in relation to optimum requirements as a function of age and sex. Current knowledge on the biochemical properties of zinc which are critical to the essential role of this metal in biological systems is summarized. Dietary and physiological factors influencing the bioavailability and utilization of zinc are considered with special attention to interactions with iron and copper status. The effects of zinc deficiency and toxicity are reviewed with respect to specific organs, immunological and reproductive function, and genotoxicity and carcinogenicity. Finally, key questions are identified where research is needed, such as the risks to human health of altered environmental distribution of zinc, assessment of zinc status in humans, effects of zinc status in relation to other essential metals on immune function, reproduction, neurological function, and the cardiovascular system, and mechanistic studies to further elucidate the biological effects of zinc at the molecular level.

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Metadata

Authors
Walsh, C. T., Sandstead, H. H., Prasad, A. S., Newberne, P. M., & Fraker, P. J.
Venue
Environmental Health Perspectives
Publisher
American Chemical Society (ACS)
Published
1994-06
Volume
102
Issue
suppl 2
Pages
5-46
ISSN
  • 0091-6765 (ISSN-L)
  • 1552-9924
DOI
10.1289/ehp.941025
OpenAlex
W2065767835
Cited by
434
References
238
FWCI
13.19
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Zinc: health effects and research priorities for the 1990s. https://app.cochat.ai/papers/10.1289/ehp.941025
The paper
Walsh, C. T., Sandstead, H. H., Prasad, A. S., Newberne, P. M., & Fraker, P. J. (1994). Zinc: health effects and research priorities for the 1990s. Environmental Health Perspectives. https://doi.org/10.1289/ehp.941025

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.