The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Organization versus activation: the role of endocrine-disrupting contaminants (EDCs) during embryonic development in wildlife.
Open accessAbstract
Many environmental contaminants disrupt the vertebrate endocrine system. Although they may be no more sensitive to endocrine-disrupting contaminants (EDCs) than other vertebrates, reptiles are good sentinels of exposure to EDCs due to the lability in their sex determination. This is exemplified by a study of alligators at Lake Apopka, Florida, showing that EDCs have altered the balance of reproductive hormones resulting in reproductive dysfunction. Such alterations may be activationally or organizationally induced. Much research emphasizes the former, but a complete understanding of the influence of EDCs in nature can be generated only after consideration of both activational and organizational alterations. The organizational model suggests that a small quantity of an EDC, administered during a specific period of embryonic development, can permanently modify the organization of the reproductive, immune, and nervous systems. Additionally, this model helps explain evolutionary adaptations to naturally occurring estrogenic compounds, such as phytoestrogens.
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Cites
Developmental effects of endocrine-disrupting chemicals in wildlife and humans.
Colborn, T., vom Saal, F. S., & Soto, A. M. (1993) · Environmental Health Perspectives · doi:10.1289/ehp.93101378 · Cited by 3,445
PHOENIX, C. H., GOY, R. W., GERALL, A. A., & YOUNG, W. C. (1959) · Endocrinology · doi:10.1210/endo-65-3-369 · Cited by 1,934
Estrogenic Effects of Effluents from Sewage Treatment Works
Purdom, C. E., Hardiman, P. A., Bye, V. V. J., Eno, N. C., Tyler, C. R., & Sumpter, J. P. (1994) · Chemistry and Ecology · doi:10.1080/02757549408038554 · Cited by 1,697
Molecular aspects of ligand binding to serum albumin.
Kragh-Hansen, U. (1981) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06849-8 · Cited by 1,544
Guillette, L. J., Gross, T. S., Masson, G. R., Matter, J. M., Percival, H. F., & Woodward, A. R. (1994) · Environmental Health Perspectives · doi:10.1289/ehp.94102680 · Cited by 1,200
Self-citationChemically-induced alterations in sexual and functional development : the wildlife/human connection
Colborn, T., & Clement, C. (1992) · Medical Entomology and Zoology · Cited by 1,046
The Free Hormone Hypothesis: A Physiologically Based Mathematical Model*
MENDEL, C. M. (1989) · Endocrine Reviews · doi:10.1210/edrv-10-3-232 · Cited by 961
Janzen, D. H. (1980) · Evolution · doi:10.1111/j.1558-5646.1980.tb04849.x · Cited by 953
Organizational and activational effects of sex steroids on brain and behavior: A reanalysis
ARNOLD, A. (1985) · Hormones and Behavior · doi:10.1016/0018-506x(85)90042-x · Cited by 804
Bull, J. J. (1980) · The Quarterly Review of Biology · doi:10.1086/411613 · Cited by 774
Cited by
Vitellogenesis as a biomarker for estrogenic contamination of the aquatic environment.
Sumpter, J. P., & Jobling, S. (1995) · Environmental Health Perspectives · doi:10.1289/ehp.95103s7173 · Cited by 1,444
Guillette Jr., L. J., Pickford, D. B., Crain, D. A., Rooney, A. A., & Percival, H. F. (1996) · General and Comparative Endocrinology · doi:10.1006/gcen.1996.0005 · Cited by 398
Self-citationEndocrine disruptors and human health--is there a problem? An update.
Safe, S. H. (2000) · Environmental Health Perspectives · doi:10.1289/ehp.00108487 · Cited by 351
Male Reproductive Health and Environmental Xenoestrogens
Toppari, J., Larsen, J. C., Christiansen, P., Giwercman, A., Grandjean, P., Guillette, L. J., Jegou, B., Jensen, T. K., Jouannet, P., Keiding, N., et al. (1996) · Environmental Health Perspectives · doi:10.2307/3432709 · Cited by 348
Self-citationVonier, P. M., Crain, D. A., McLachlan, J. A., Guillette, L. J., & Arnold, S. F. (1996) · Environmental Health Perspectives · doi:10.1289/ehp.961041318 · Cited by 255
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Metadata
- Authors
- Guillette, L. J., Crain, D. A., Rooney, A. A., & Pickford, D. B.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 1995-10
- Volume
- 103
- Issue
- suppl 7
- Pages
- 157-164
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W2007644354
- Cited by
- 340
- References
- 45
- FWCI
- 14.84
- Type
- journal article
- Language
- en
- Open access
- gold
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- Guillette, L. J., Crain, D. A., Rooney, A. A., & Pickford, D. B. (1995). Organization versus activation: the role of endocrine-disrupting contaminants (EDCs) during embryonic development in wildlife. Environmental Health Perspectives. https://doi.org/10.1289/ehp.95103s7157
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
