The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Bioavailable transition metals in particulate matter mediate cardiopulmonary injury in healthy and compromised animal models.
Open accessAbstract
Many epidemiologic reports associate ambient levels of particulate matter (PM) with human mortality and morbidity, particularly in people with preexisting cardiopulmonary disease (e.g., chronic obstructive pulmonary disease, infection, asthma). Because much ambient PM is derived from combustion sources, we tested the hypothesis that the health effects of PM arise from anthropogenic PM that contains bioavailable transition metals. The PM samples studied derived from three emission sources (two oil and one coal fly ash) and four ambient airsheds (St. Louis, MO; Washington; Dusseldorf, Germany; and Ottawa, Canada). PM was administered to rats by intratracheal instillation in equimass or equimetal doses to address directly the influence of PM mass versus metal content on acute lung injury and inflammation. Our results indicated that the lung dose of bioavailable transition metal, not instilled PM mass, was the primary determinant of the acute inflammatory response for both the combustion source and ambient PM samples. Residual oil fly ash, a combustion PM rich in bioavailable metal, was evaluated in a rat model of cardiopulmonary disease (pulmonary vasculitis/hypertension) to ascertain whether the disease state augmented sensitivity to that PM. Significant mortality and enhanced airway responsiveness were observed. Analysis of the lavaged lung fluids suggested that the milieu of the inflamed lung amplified metal-mediated oxidant chemistry to jeopardize the compromised cardiopulmonary system. We propose that soluble metals from PM mediate the array of PM-associated injuries to the cardiopulmonary system of the healthy and at-risk compromised host.
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Cites
An association between air pollution and mortality in six U.S. cities
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Particulate Air Pollution and Hospital Emergency Room Visits for Asthma in Seattle
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Cited by
Brook, R. D., Franklin, B., Cascio, W., Hong, Y., Howard, G., Lipsett, M., Luepker, R., Mittleman, M., Samet, J., Smith, S. C., et al. (2004) · Circulation · doi:10.1161/01.cir.0000128587.30041.c8 · Cited by 2,380
Oxidative stress: Its role in air pollution and adverse health effects
Kelly, F. J. (2003) · Occupational and Environmental Medicine · doi:10.1136/oem.60.8.612 · Cited by 817
West, J. J., Cohen, A., Dentener, F., Brunekreef, B., Zhu, T., Armstrong, B., Bell, M. L., Brauer, M., Carmichael, G., Costa, D. L., et al. (2016) · Environmental Science & Technology · doi:10.1021/acs.est.5b03827 · Cited by 390
Self-citationBirmili, W., Allen, A. G., Bary, F., & Harrison, R. M. (2006) · Environmental Science & Technology · doi:10.1021/es0486925 · Cited by 386
Differentiating the effects of fine and coarse particles on daily mortality in Shanghai, China
Kan, H., London, S. J., Chen, G., Zhang, Y., Song, G., Zhao, N., Jiang, L., & Chen, B. (2007) · Environment International · doi:10.1016/j.envint.2006.12.001 · Cited by 339
Metadata
- Authors
- Costa, D. L., & Dreher, K. L.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 1997-09
- Volume
- 105
- Issue
- suppl 5
- Pages
- 1053-1060
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W2026811587
- Cited by
- 522
- References
- 20
- FWCI
- 12.43
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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