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Uterotrophic activity of bisphenol A in the immature rat.
Open accessAbstract
Bisphenol A (BPA) is active in immature AP rat uterotrophic assays when evaluated using either the oral or the subcutaneous (sc) injection routes of exposure (three daily administrations of 400-800 mg/kg BPA). Premature vaginal opening was seen for 8 of 14 animals exposed to 600 and 800 mg/kg BPA by sc injection. Vaginal opening was not produced by BPA in the gavage studies. These results are consistent with those of Dodds and Lawson [Nature 137:96 (1936)] who found that BPA induces persistent vaginal cornification in ovariectomized rats exposed to three twice-daily injections of 85 mg/kg BPA (total daily dose 170 mg/kg), but they conflict with the reported inactivity of BPA in the immature mouse uterotrophic assay. The uterotrophic activity of diethylstilbestrol in the rat is also established (0.04 mg/kg/day for three days).
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Cited by
In vivo effects of bisphenol A in laboratory rodent studies
Richter, C. A., Birnbaum, L. S., Farabollini, F., Newbold, R. R., Rubin, B. S., Talsness, C. E., Vandenbergh, J. G., Walser-Kuntz, D. R., & vom Saal, F. S. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.06.004 · Cited by 1,147
Matthews, J. B., Twomey, K., & Zacharewski, T. R. (2001) · Chemical Research in Toxicology · doi:10.1021/tx0001833 · Cited by 465
Low dose effects of bisphenol A on sexual differentiation of the brain and behavior in rats
Kubo, K., Arai, O., Omura, M., Watanabe, R., Ogata, R., & Aou, S. (2003) · Neuroscience Research · doi:10.1016/s0168-0102(02)00251-1 · Cited by 311
An evaluation of evidence for the carcinogenic activity of bisphenol A
Keri, R. A., Ho, S.-M., Hunt, P. A., Knudsen, K. E., Soto, A. M., & Prins, G. S. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.06.008 · Cited by 285
CAR and PXR: Xenosensors of endocrine disrupters?
Kretschmer, X. C., & Baldwin, W. S. (2005) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2005.06.003 · Cited by 268
Metadata
- Authors
- Ashby, J., & Tinwell, H.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 1998-11
- Volume
- 106
- Issue
- 11
- Pages
- 719-720
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W2084709535
- Cited by
- 196
- References
- 0
- FWCI
- 19.86
- Type
- journal article
- Language
- en
- Open access
- gold
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- Ashby, J., & Tinwell, H. (1998). Uterotrophic activity of bisphenol A in the immature rat. Environmental Health Perspectives. https://doi.org/10.1289/ehp.98106719
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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