The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.
Estimates of the Global Burden of Ambient PM2.5, Ozone, and NO2 on Asthma Incidence and Emergency Room Visits
Open accessAbstract
Background: Asthma is the most prevalent chronic respiratory disease worldwide, affecting 358 million people in 2015. Ambient air pollution exacerbates asthma among populations around the world and may also contribute to new-onset asthma. Objectives: We aimed to estimate the number of asthma emergency room visits and new onset asthma cases globally attributable to fine particulate matter (PM2.5), ozone, and nitrogen dioxide (NO2) concentrations. Methods: We used epidemiological health impact functions combined with data describing population, baseline asthma incidence and prevalence, and pollutant concentrations. We constructed a new dataset of national and regional emergency room visit rates among people with asthma using published survey data. Results: We estimated that 9–23 million and 5–10 million annual asthma emergency room visits globally in 2015 could be attributable to ozone and PM2.5, respectively, representing 8–20% and 4–9% of the annual number of global visits, respectively. The range reflects the application of central risk estimates from different epidemiological meta-analyses. Anthropogenic emissions were responsible for ∼37% and 73% of ozone and PM2.5 impacts, respectively. Remaining impacts were attributable to naturally occurring ozone precursor emissions (e.g., from vegetation, lightning) and PM2.5 (e.g., dust, sea salt), though several of these sources are also influenced by humans. The largest impacts were estimated in China and India. Conclusions: These findings estimate the magnitude of the global asthma burden that could be avoided by reducing ambient air pollution. We also identified key uncertainties and data limitations to be addressed to enable refined estimation. https://doi.org/10.1289/EHP3766
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In the citing paper
“An estimated 9–23 million (8–20% of total) asthma-related emergency room visits globally were attributable to ozone (74).”
From Ozone pollution: A Major health hazard worldwide (2019) · cites this paper as [74]
In the citing paper
“Worldwide, in 2015, 9–23 million and 5–10 million annual asthma emergency room visits have been attributed to the outdoor air pollutants ozone and particulate matter with an aerodynamic diameter <2.5 μm (PM2.5), respectively.”
From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [121]
In the citing paper
“Outdoor air pollution almost certainly has a major global impact on asthma for children and adults, especially in China and India (121).”
From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [121]
In the citing paper
“Worldwide, in 2015, 9–23 million and 5–10 million annual asthma emergency room visits have been attributed to the outdoor air pollutants ozone and particulate matter with an aerodynamic diameter <2.5 μm (PM2.5), respectively.”
From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [121]
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Self-citationCohen, A. J., Brauer, M., Burnett, R., Anderson, H. R., Frostad, J., Estep, K., Balakrishnan, K., Brunekreef, B., Dandona, L., Dandona, R., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)30505-6 · Cited by 6,583
Self-citationSoriano, J. B., Abajobir, A. A., Abate, K. H., Abera, S. F., Agrawal, A., Ahmed, M. B., Aichour, A. N., Aichour, I., Aichour, M. T. E., Alam, K., et al. (2017) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(17)30293-x · Cited by 2,602
Self-citationGakidou, E., Afshin, A., Abajobir, A. A., Abate, K. H., Abbafati, C., Abbas, K. M., Abd-Allah, F., Abdulle, A. M., Abera, S. F., Aboyans, V., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)32366-8 · Cited by 2,406
Self-citationBurnett, R. T., Pope, C. A., Ezzati, M., Olives, C., Lim, S. S., Mehta, S., Shin, H. H., Singh, G., Hubbell, B., Brauer, M., et al. (2014) · Environmental Health Perspectives · doi:10.1289/ehp.1307049 · Cited by 1,901
Self-citationOutdoor air pollution and asthma.
Guarnieri, M., & Balmes, J. R. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60617-6 · Cited by 1,889
Development and evaluation of an Earth-System model – HadGEM2
Collins, W. J., Bellouin, N., Doutriaux, M., Gedney, N., Halloran, P. R., Hinton, T. J., Hughes, J., JONES, C. D., Joshi, M., Liddicoat, S. K., et al. (2011) · Geoscientific model development · doi:10.5194/gmd-4-1051-2011 · Cited by 1,538
van Donkelaar, A., Martin, R. V., Brauer, M. D., Hsu, N.-Y. C., Kahn, R. A., Levy, R. C., Lyapustin, A., Sayer, A. M., & Winker, D. M. M. (2016) · Environmental Science & Technology · doi:10.1021/acs.est.5b05833 · Cited by 1,209
Self-citationPROPORTION OF DISEASE CAUSED OR PREVENTED BY A GIVEN EXPOSURE, TRAIT OR INTERVENTION1
MIETTINEN, O. S. (1974) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a121617 · Cited by 1,036 · cited 2×
“We found six additional meta-analyses reporting relationships between asthma ERVs and PM2:5 and NO2 for children only (Fan et al. 2016; Favarato et al. 2014; Gehring et al. 2015; Lim et al. 2016; Mölter et al. 2015; Weinmayr et al. 2010).”
BackgroundRabe, K. F., Adachi, M., Lai, C. K. W., Soriano, J. B., Vermeire, P. A., Weiss, K. B., & Weiss, S. T. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.04.042 · Cited by 940
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Metadata
- Authors
- Anenberg, S. C., Henze, D. K., Tinney, V., Kinney, P. L., Raich, W., Fann, N., Malley, C. S., Roman, H., Lamsal, L., Duncan, B., Martin, R. V., van Donkelaar, A., Brauer, M., Doherty, R., Jonson, J. E., Davila, Y., Sudo, K., & Kuylenstierna, J. C. I.
- Affiliations
- George Washington University (US)
- University of Colorado Boulder (US)
- Boston University (US)
- Industrial Economics, Inc. , Cambridge, Massachusetts,
- Environmental Protection Agency (US)
- Stockholm Environment Institute , York,
- Goddard Space Flight Center (US)
- Dalhousie University (CA)
- Dalhousie University , Halifax, Nova Scotia,
- University of British Columbia (CA)
- University of Edinburgh (GB)
- Norwegian Meteorological Institute (NO)
- Japan Agency for Marine-Earth Science and Technology (JP)
- Stockholm Environment Institute (GB)
- Corresponding author
- Anenberg, Susan C.
- ORCID
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-10-01
- Volume
- 126
- Issue
- 10
- Pages
- 107004-107004
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- PMC
- PMC6371661
- OpenAlex
- W2898247900
- Cited by
- 337
- References
- 71
- Citations by year
- 2026: 19 · 2025: 45 · 2024: 51 · 2023: 38 · 2022: 48 · 2021: 55 · 2020: 47 · 2019: 34
- FWCI
- 16.80
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- public-domain
- creativecommons.org/licenses/by/4.0/ (vor)
- Locations
- Environmental Health Perspectives (publishedVersion, public-domain)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
- CU Scholar (University of Colorado Boulder) (submittedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Funders
- National Aeronautics and Space Administration
- Stockholm Environment Institute
- Institute for Health Metrics and Evaluation
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
- Keywords
- asthma, ambient air pollution, PM2.5, ozone, nitrogen dioxide, emergency department visits, new-onset asthma, attributable burden, anthropogenic emissions, respiratory disease burden, China, India
- MeSH terms
- Air Pollution, Asthma, Emergency Service, Hospital, Environmental Exposure, Humans, Nitrogen Dioxide, Ozone, Particle Size, Risk Factors, Incidence, Particulate Matter
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