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Sensitivity to titanium. A cause of implant failure?
Abstract
Tissues from five patients who underwent revision operations for failed total hip replacements were found to contain large quantities of particulate titanium. In four cases this metal must have come from titanium alloy screws used to fix the acetabular component; in the fifth case it may also have originated from a titanium alloy femoral head. Monoclonal antibody labelling showed abundant macrophages and T-lymphocytes, in the absence of B-lymphocytes, suggesting sensitisation to titanium. Skin patch testing with dilute solutions of titanium salts gave negative results in all five patients. However, two of them had a positive skin test to a titanium-containing ointment.
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Citations
Cited by
Metal Sensitivity in Patients with Orthopaedic Implants
Hallab, N., Merritt, K., & Jacobs, J. J. (2001) · The Journal of Bone and Joint Surgery-American Volume · doi:10.2106/00004623-200103000-00017 · Cited by 935
General review of titanium toxicity
Kim, K. T., Eo, M. Y., Nguyen, T. T. H., & Kim, S. M. (2019) · International Journal of Implant Dentistry · doi:10.1186/s40729-019-0162-x · Cited by 404
Wear particles, periprosthetic osteolysis and the immune system
Goodman, S. B. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.06.035 · Cited by 340
Metadata
- Authors
- Lalor, P., Revell, P., Gray, A., Wright, S., Railton, G., & Freeman, M.
- Venue
- The Journal of Bone and Joint Surgery. British volume
- Published
- 1991-01
- Volume
- 73-B
- Issue
- 1
- Pages
- 25-28
- ISSN
- 0301-620X (ISSN-L)
- 2044-5377
- OpenAlex
- W2135657116
- Cited by
- 393
- References
- 0
- FWCI
- 10.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Sensitivity to titanium. A cause of implant failure? https://app.cochat.ai/papers/10.1302/0301-620x.73b1.1991768
- The paper
- Lalor, P., Revell, P., Gray, A., Wright, S., Railton, G., & Freeman, M. (1991). Sensitivity to titanium. A cause of implant failure? The Journal of Bone and Joint Surgery. British volume. https://doi.org/10.1302/0301-620x.73b1.1991768
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
