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Cited by 431

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A randomised controlled trial of kinematically and mechanically aligned total knee replacements: Two-year clinical results

Dossett, H. G., Estrada, N. A., Swartz, G. J., LeFevre, G. W., Kwasman, B. G.·2014·The Bone & Joint Journal

Abstract

We have previously reported the short-term radiological results of a randomised controlled trial comparing kinematically aligned total knee replacement (TKR) and mechanically aligned TKR, along with early pain and function scores. In this study we report the two-year clinical results from this trial. A total of 88 patients (88 knees) were randomly allocated to undergo either kinematically aligned TKR using patient-specific guides, or mechanically aligned TKR using conventional instruments. They were analysed on an intention-to-treat basis. The patients and the clinical evaluator were blinded to the method of alignment. At a minimum of two years, all outcomes were better for the kinematically aligned group, as determined by the mean Oxford knee score (40 (15 to 48) versus 33 (13 to 48); p = 0.005), the mean Western Ontario McMaster Universities Arthritis index (WOMAC) (15 (0 to 63) versus 26 (0 to 73); p = 0.005), mean combined Knee Society score (160 (93 to 200) versus 137 (64 to 200); p= 0.005) and mean flexion of 121° (100 to 150) versus 113° (80 to 130) (p = 0.002). The odds ratio of having a pain-free knee at two years with the kinematically aligned technique (Oxford and WOMAC pain scores) was 3.2 (p = 0.020) and 4.9 (p = 0.001), respectively, compared with the mechanically aligned technique. Patients in the kinematically aligned group walked a mean of 50 feet further in hospital prior to discharge compared with the mechanically aligned group (p = 0.044). In this study, the use of a kinematic alignment technique performed with patient-specific guides provided better pain relief and restored better function and range of movement than the mechanical alignment technique performed with conventional instruments. Cite this article: Bone Joint J 2014;96-B:907–13.

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Metadata

Authors
Dossett, H. G., Estrada, N. A., Swartz, G. J., LeFevre, G. W., & Kwasman, B. G.
Venue
The Bone & Joint Journal
Published
2014-07
Volume
96-B
Issue
7
Pages
907-913
ISSN
  • 2049-4394 (ISSN-L)
  • 2049-4408
OpenAlex
W2188187560
Cited by
431
References
20
FWCI
27.48
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: A randomised controlled trial of kinematically and mechanically aligned total knee replacements: Two-year clinical results. https://app.cochat.ai/papers/10.1302/0301-620x.96b7.32812
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Dossett, H. G., Estrada, N. A., Swartz, G. J., LeFevre, G. W., & Kwasman, B. G. (2014). A randomised controlled trial of kinematically and mechanically aligned total knee replacements: Two-year clinical results. The Bone & Joint Journal. https://doi.org/10.1302/0301-620x.96b7.32812

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