Reducing Undercarboxylated Osteocalcin With Vitamin K Supplementation Does Not Promote Lean Tissue Loss or Fat Gain Over 3 Years in Older Women and Men: A Randomized Controlled Trial
Open accessAbstract
Osteocalcin (OC) is a vitamin K–dependent protein synthesized during bone formation. Mice injected with the undercarboxylated form of OC (ucOC) had more skeletal muscle mass and less fat mass than sham-treated controls, suggesting a unique metabolic role for ucOC. UcOC decreases in response to vitamin K supplementation. Our objective was to determine the effect of reducing ucOC on change in lean tissue and fat mass in older community-dwelling adults (n = 401, mean ± SD 69 ± 6 years) using data from a randomized controlled trial of vitamin K supplementation. Over 3 years, serum ucOC was reduced by 58% in women and by 61% in men randomized to vitamin K, whereas in the control group, ucOC decreased by 1% in women and 4% in men (supplementation*time p < 0.001 in men and women). However, there were no differences in the change in appendicular lean mass (calculated as arm lean mass + leg lean mass) or total body fat mass between women randomized to vitamin K and control over 3 years (supplementation*time p values all ≥ 0.18) or between men randomized to vitamin K and control (supplementation*time p values all ≥ 0.54). Consistent with these findings, ucOC was not associated cross-sectionally with appendicular lean mass or fat mass in men or women after adjustment for total OC at baseline (all p ≥ 0.12). These findings indicate the undercarboxylated form of OC is not implicated in age-related changes in skeletal muscle or adipose tissue mass in older community-dwelling adults. © 2016 American Society for Bone and Mineral Research.
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One study reported that over three years vitamin K supplementation was not implicated in age-related changes in skeletal muscle or adipose tissue mass in older community-dwelling adults.
“One study464 reported that over 3 years vitamin K supplementation was not implicated in the age-related changes in skeletal muscle or adipose tissue mass in older community-dwelling adults.”
From Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies (2018) · cites this paper as [464]
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- Authors
- Shea, M. K., Dawson-Hughes, B., Gundberg, C. M., & Booth, S. L.
- Affiliations
- Tufts University (US)
- USDA Human Nutrition Research Center on AgingTufts UniversityBostonMAUSA
- Yale University (US)
- Corresponding author
- Shea, M Kyla
- Venue
- Journal of Bone and Mineral Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-09-07
- Volume
- 32
- Issue
- 2
- Pages
- 243-249
- ISSN
- 0884-0431 (ISSN-L)
- 1523-4681
- PMC
- PMC5292074
- OpenAlex
- W2516367744
- Cited by
- 31
- References
- 40
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 5 · 2019: 4 · 2018: 3 · 2017: 3 · 2015: 1
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Journal of Bone and Mineral Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (R01AG14759, R01HL69272, K01AR063167)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin K Research Studies
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Keywords
- undercarboxylated osteocalcin, vitamin K supplementation, lean body mass, fat mass, appendicular lean mass, skeletal muscle, adipose tissue, aging, older adults, bone formation, community-dwelling adults
- MeSH terms
- Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Thinness, Vitamin K, Osteocalcin, Dietary Supplements, Adiposity
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