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Cited by 178Bone health and treatmentsBone health and osteoporosis researchBone fractures and treatments

Effect of bisphosphonate (Incadronate) on fracture healing of long bones in rats.

Li, Jiliang, Mori, Satoshi, Kaji, Yoshio, Mashiba, Tasuku, Kawanishi, Jun, Norimatsu, Hiromichi·1999·Journal of Bone and Mineral Research
DOI 10.1359/jbmr.1999.14.6.969
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Abstract

This study was designed to test whether bisphosphonates disturb the process of fracture healing. Female Sprague-Dawley rats were injected with either two doses of bisphosphonate (incadronate) (10 μg/kg and 100 μg/kg) or vehicle three times a week for 2 weeks. Right femora were then fractured and fixed with intramedullary wires. Incadronate treatment was stopped in pretreatment groups (P-10 and P-100 groups), while the treatment was continued in continuous treatment groups (C-10 and C-100 groups). Animals were sacrificed at 6 and 16 weeks after surgery. Soft X-ray of all fractured femora was taken. After mechanical testing, fractured femora were stained in Villanueva bone stain and embedded in methyl methacrylate. Cross-sections near fracture line were analyzed by microradiography and histomorphometry. Radiographic study showed that bony callus was present in all the fractures and incadronate treatment led to a larger callus, especially in C-100 group at both 6 and 16 weeks. Histologic study showed that the process of fracture healing in pretreatment groups was delayed at 6 weeks, but reached control level thereafter and showed same characteristics as in control at 16 weeks. Woven bony callus could still be seen in continuous treatment groups at 16 weeks. Mechanical study indicated that the ultimate load of C-100 group was slightly higher than the other treatment groups and control. The results suggest that pretreatment with incadronate did not affect fracture healing at 16 weeks after fracture. However, continuous incadronate treatment could lead to larger callus, but it delayed remodeling process during fracture healing, especially with high-dose treatment.

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Authors
Li, J., Mori, S., Kaji, Y., Mashiba, T., Kawanishi, J., & Norimatsu, H.
Affiliations
Kagawa University (JP)
Corresponding author
Mori, Satoshi
ORCID
Venue
Journal of Bone and Mineral Research
Publisher
Oxford University Press (OUP)
Published
1999-06-01
Volume
14
Issue
6
Pages
969-979
ISSN
  • 0884-0431 (ISSN-L)
  • 1523-4681
DOI
10.1359/jbmr.1999.14.6.969
OpenAlex
W1973514169
Cited by
178
References
51
Citations by year
2026: 4 · 2024: 5 · 2023: 2 · 2022: 4 · 2021: 8 · 2020: 6 · 2019: 6 · 2018: 3 · 2017: 7 · 2016: 7 · 2015: 8 · 2014: 9 · 2013: 6 · 2012: 7
FWCI
1.49
Type
journal article
Language
en
Open access
closed
Licence
academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations
  • Journal of Bone and Mineral Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Bone health and treatments
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Epidemiology › Bone fractures and treatments
Keywords
bisphosphonates, incadronate, fracture healing, long bones, femoral fracture, bone callus, bone remodeling, intramedullary fixation, histomorphometry, ultimate load, dose-dependent effects
MeSH terms
Animals, Bone and Bones, Bony Callus, Diphosphonates, Drug Administration Schedule, Drug Evaluation, Preclinical, Female, Radiography, Stress, Mechanical, Fracture Healing, Rats, Sprague-Dawley, Rats

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