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Cited by 176Vitamin D Research StudiesParathyroid Disorders and TreatmentsBone health and osteoporosis research

Vitamin A antagonizes calcium response to vitamin D in man

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Johansson, S., Melhus, H.·2001·Journal of Bone and Mineral Research
DOI 10.1359/jbmr.2001.16.10.1899
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Abstract

For unknown reasons, the highest incidence of osteoporosis is found in northern Europe. In these populations, the sunlight exposure is limited and the vitamin A intake is high. The interaction between vitamin A and D has been the subject of several in vitro and animal studies. We have studied the acute effects of vitamin A and D on calcium homeostasis in 9 healthy human subjects. We compared the effect of (i) 15 mg of retinyl palmitate, (ii) 2 μg of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], (iii) 15 mg of retinyl palmitate plus 2 μg of 1,25(OH)2D3, and (iv) placebo in a double-blind crossover study. The subjects took vitamin preparations at 10:00 p.m. and the following day blood samples were collected five times from 8:00 a.m. to 4:00 p.m. Serum levels of 1,25(OH)2D3 and retinyl esters increased (1.7-fold and 8.3-fold, respectively; p < 0.01). As expected, serum calcium (S-calcium) increased (2.3%; p < 0.01) and S-parathyroid hormone (PTH) decreased (−32%,;p < 0.05) after 1,25(OH)2D3 intake. In contrast, retinyl palmitate intake resulted in a significant decrease in S-calcium when taken alone (−1.0%; p < 0.05) and diminished the calcium response to 1,25(OH)2D3 after the combined intake (1.4%; p < 0.01). S-PTH was unaffected by retinyl palmitate. No significant changes in serum levels of the degradation product of C-telopeptide of type I collagen (CrossLaps), or U-calcium/creatinine levels were found. In conclusion, an intake of vitamin A corresponding to about one serving of liver antagonizes the rapid intestinal calcium response to physiological levels of vitamin D in man.

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  • High vitamin A levels decrease calcium absorption by mediating the vitamin D-calcium response.

    “and similarly, high vitamin A levels decrease calcium absorption by mediating the vitamin D-calcium response [274,275]”

    From Vitamin A Update: Forms, Sources, Kinetics, Detection, Function, Deficiency, Therapeutic Use and Toxicity (2021) · cites this paper as [274]

    The Discussion (p. 5) concludes that vitamin A antagonizes the serum-calcium response to vitamin D. The Discussion (p. 4) says this may occur at the level of intestinal calcium absorption, but that mechanism was not confirmed; the claim states decreased absorption as an established effect. (LLM, conf=0.88)

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Research works printed but not linked: 3

  1. [5]5. Armstrong R, Ashenfelter K, Eckoff C, Levin A, Shapiro S 1994 General and reproductive toxicology of retinoids. In: Sporn M, Roberts A, Goodman D (eds.) The Retinoids, 2nd ed., vol 1. Raven Press, New York, NY, USA, pp. 545-572.
  2. [17]17. Åman L, Nilsson I, O ¨ hlund M, Becker W, Bruce Å 1992 A Nutrition Guide. Swedish Food Administration, Uppsala, Sweden, pp. 12-13.
  3. [48]48. FAO/WHO 1988 Requirements of vitamin A, iron, folate, and vitamin B12. FAO Report of a joint FAO/WHO Expert Consultation., vol. 23. FAO Press, Rome, Italy, pp. 85-89. Address reprint requests to: Sara Johansson Department of Medical Sciences Ing. 70 3 tr, University Hospital S-751 85 Uppsala, Sweden Received in original form December 11, 2000; in revised form April 17, 2001; accepted May 11, 2001. 15234681, 2001, 10, Downloaded from https://asbmr.onlinelibrary.wiley.com/doi/10.1359/jbmr.2001.16.10.1899, Wiley Online Library on [30/12/2023]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License

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Authors
Johansson, S., & Melhus, H.
Affiliations
Uppsala University Hospital (SE)
Corresponding author
Johansson, S.
ORCID
Melhus, H.
Venue
Journal of Bone and Mineral Research
Publisher
Oxford University Press (OUP)
Published
2001-10-01
Volume
16
Issue
10
Pages
1899-1905
ISSN
  • 0884-0431 (ISSN-L)
  • 1523-4681
DOI
10.1359/jbmr.2001.16.10.1899
OpenAlex
W1985082055
Cited by
176
References
48
Citations by year
2026: 6 · 2025: 8 · 2024: 9 · 2023: 3 · 2022: 5 · 2021: 10 · 2020: 10 · 2019: 6 · 2018: 3 · 2017: 6 · 2016: 7 · 2015: 7 · 2014: 3 · 2013: 11 · 2012: 10
FWCI
5.29
Type
journal article
Language
en
Open access
Licence
academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations
  • Journal of Bone and Mineral Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
Vetenskapsrådet
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
  • Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Keywords
vitamin A, vitamin D, retinyl palmitate, 1,25-dihydroxyvitamin D3, calcium homeostasis, serum calcium, parathyroid hormone, osteoporosis, sun exposure
MeSH terms
Retinyl Esters, Adult, Calcitriol, Calcium, Diterpenes, Double-Blind Method, Female, Humans, Male, Vitamin A, Cross-Over Studies

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