The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Insulin‐Like Growth Factor I Is Required for the Anabolic Actions of Parathyroid Hormone on Mouse Bone
Open accessAbstract
Parathyroid hormone (PTH) is a potent anabolic agent for bone, but the mechanism(s) by which it works remains imperfectly understood. Previous studies have indicated that PTH stimulates insulin‐like growth factor (IGF) I production, but it remains uncertain whether IGF‐I mediates some or all of the skeletal actions of PTH. To address this question, we examined the skeletal response to PTH in IGF‐I‐deficient (knockout [k/o]) mice. These mice and their normal littermates (NLMs) were given daily injections of PTH (80 μg/kg) or vehicle for 2 weeks after which their tibias were examined for fat‐free weight (FFW), bone mineral content, bone structure, and bone formation rate (BFR), and their femurs were assessed for mRNA levels of osteoblast differentiation markers. In wild‐type mice, PTH increased FFW, periosteal BFR, and cortical thickness (C.Th) of the proximal tibia while reducing trabecular bone volume (BV); these responses were not seen in the k/o mice. The k/o mice had normal mRNA levels of the PTH receptor and increased mRNA levels of the IGF‐I receptor but markedly reduced basal mRNA levels of the osteoblast markers. Surprisingly, these mRNAs in the k/o bones increased several‐fold more in response to PTH than the mRNAs in the bones from their wild‐type littermates. These results indicate that IGF‐I is required for the anabolic actions of PTH on bone formation, but the defect lies distal to the initial response of the osteoblast to PTH.
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Anabolic Actions of Parathyroid Hormone on Bone*
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Cited by
Growth Hormone, Insulin-Like Growth Factors, and the Skeleton
Giustina, A., Mazziotti, G., & Canalis, E. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0036 · Cited by 914
Molecular and cellular mechanisms of the anabolic effect of intermittent PTH
Jilka, R. L. (2007) · Bone · doi:10.1016/j.bone.2007.03.017 · Cited by 720
Bone marrow mesenchymal stem cells and TGF-β signaling in bone remodeling
Crane, J. L., & Cao, X. (2014) · Journal of Clinical Investigation · doi:10.1172/jci70050 · Cited by 448
Energy Metabolism of the Osteoblast: Implications for Osteoporosis
Lee, W.-C., Guntur, A. R., Long, F., & Rosen, C. J. (2017) · Endocrine Reviews · doi:10.1210/er.2017-00064 · Cited by 443
Self-citationTransforming growth factor‐β in stem cells and tissue homeostasis
Xu, X., Zheng, L., Yuan, Q., Zhen, G., Crane, J. L., Zhou, X., & Cao, X. (2018) · Bone Research · doi:10.1038/s41413-017-0005-4 · Cited by 414
Metadata
- Authors
- Bikle, D. D., Sakata, T., Leary, C., Elalieh, H., Ginzinger, D., Rosen, C. J., Beamer, W., Majumdar, S., & Halloran, B. P.
- Venue
- Journal of Bone and Mineral Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-09
- Volume
- 17
- Issue
- 9
- Pages
- 1570-1578
- ISSN
- 0884-0431 (ISSN-L)
- 1523-4681
- OpenAlex
- W2001956022
- Cited by
- 259
- References
- 30
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Insulin‐Like Growth Factor I Is Required for the Anabolic Actions of Parathyroid Hormone on Mouse Bone. https://app.cochat.ai/papers/10.1359/jbmr.2002.17.9.1570
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- Bikle, D. D., Sakata, T., Leary, C., Elalieh, H., Ginzinger, D., Rosen, C. J., Beamer, W., Majumdar, S., & Halloran, B. P. (2002). Insulin‐Like Growth Factor I Is Required for the Anabolic Actions of Parathyroid Hormone on Mouse Bone. Journal of Bone and Mineral Research. https://doi.org/10.1359/jbmr.2002.17.9.1570
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