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The DOI matches its Crossref record; 479 of the 479 references it cites were found in a registry or an index.

Growth Hormone, Insulin-Like Growth Factors, and the Skeleton

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Giustina, Andrea, Mazziotti, Gherardo, Canalis, Ernesto·2008·Endocrine Reviews
DOI 10.1210/er.2007-0036
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Abstract

GH and IGF-I are important regulators of bone homeostasis and are central to the achievement of normal longitudinal bone growth and bone mass.Although GH may act directly on skeletal cells, most of its effects are mediated by IGF-I, which is present in the systemic circulation and is synthesized by peripheral tissues.The availability of IGF-I is regulated by IGF binding proteins.IGF-I enhances the differentiated function of the osteoblast and bone formation.Adult GH deficiency causes low bone turnover osteoporosis with high risk of ver-tebral and nonvertebral fractures, and the low bone mass can be partially reversed by GH replacement.Acromegaly is characterized by high bone turnover, which can lead to bone loss and vertebral fractures, particularly in patients with coexistent hypogonadism.GH and IGF-I secretion are decreased in aging individuals, and abnormalities in the GH/IGF-I axis play a role in the pathogenesis of the osteoporosis of anorexia nervosa and after glucocorticoid exposure.(Endocrine Reviews 29: 535-559, 2008) I. Introduction II.The Growth Hormone (GH)/Insulin-Like Growth Factor-I (IGF-I) Axis III.Mechanisms of GH and IGF-I Action in Bone A. GH B. IGF-I C. IGF binding proteins (IGFBPs) IV.Skeletal Manifestations of GH Deficiency and Excess in Humans A. Adult growth hormone deficiency (GHD) B. Skeletal effects of recombinant human GH (rhGH) in adult-onset GHD C. Skeletal manifestations of acromegaly V. Skeletal Manifestations of Selected Diseases with Abnormal GH/IGF-I Axis A. Postmenopausal and senile osteoporosis B. Anorexia nervosa C. Glucocorticoid-induced osteoporosis VI. Conclusions

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Citations

Cites

Show all 479 references

Research works printed but not linked: 24

  1. Cocchi, 2005, GH-releasing peptides and bone., J Endocrinol Invest, 28(Suppl 8), 11
  2. Coiro, 2002, Effect of potentiation of cholinergic tone by pyridostigmine on the GH response to GHRH in elderly men., Gerontology, 38, 217, 10.1159/000213331 · doi:10.1159/000213331
  3. Barnard, 1988, The ontogeny of growth hormone receptors in the rabbit tibia., Endocrinology, 122, 2562, 10.1210/endo-122-6-2562 · doi:10.1210/endo-122-6-2562
  4. Sugiyama, 2001, Carboxylation of osteocalcin may be related to bone quality: a possible mechanism of bone fracture prevention by vitamin K., J Bone Miner Res, 19, 146, 10.1007/s007740170034 · doi:10.1007/s007740170034
  5. Pash, 1995, Regulation of insulin-like growth factor I transcription by prostaglandin E2 in osteoblast cells., Endocrinology, 136, 33, 10.1210/endo.136.1.7828549 · doi:10.1210/endo.136.1.7828549
  6. Rubini, 1994, Platelet-derived growth factor increases the activity of the promoter of the insulin-like growth factor-1 (IGF-1) receptor gene., Exp Cell Res, 211, 374, 10.1006/excr.1994.1101 · doi:10.1006/excr.1994.1101
  7. Moriwake, 1992, 1,25-Dihydroxyvitamin D3 stimulates the secretion of insulin-like growth factor binding protein 3 (IGFBP-3) by cultured human osteosarcoma cells., Endocrinology, 130, 1071
  8. Bale, 2005, Disruption of insulin-like growth factor-II imprinting during embryonic development rescues the dwarf phenotype of mice null for pregnancy-associated plasma protein-A., J Endocrinol, 86, 325, 10.1677/joe.1.06259 · doi:10.1677/joe.1.06259
  9. Franchimont, 1997, Interleukin-6 and its soluble receptor regulate the expression of insulin-like growth factor binding protein-5 in osteoblast cultures., Endocrinology, 138, 3380, 10.1210/endo.138.8.5339 · doi:10.1210/endo.138.8.5339
  10. Ahmad, 2004, Parathyroid responsiveness to hypocalcemic and hypercalcemic stimuli in adult growth hormone deficiency after growth hormone replacement, Am J Physiol Endocrinol Metab, 286, E986, 10.1152/ajpendo.00325.2003 · doi:10.1152/ajpendo.00325.2003
  11. Kosowicz, 2007, Abnormalities in bone mineral density distribution and bone scintigraphy in patients with childhood onset hypopituitarism., J Clin Densitom, 10, 332, 10.1016/j.jocd.2007.03.098 · doi:10.1016/j.jocd.2007.03.098
  12. Rosen, 1995, Reduced bone mineral content in adult patients with growth hormone deficiency., Eur J Endocrinol, 132, 727
  13. Tothill, 1989, Methods of bone mineral measurement., Phys Med Biol, 34, 543, 10.1088/0031-9155/34/5/001 · doi:10.1088/0031-9155/34/5/001
  14. Caversazio, 1989, Adaptation of tubular phosphate transport: relation between phosphate requirement as influenced by growth and supply., Adv Exp Med Biol, 128, 107, 10.1007/978-1-4615-9167-2_13 · doi:10.1007/978-1-4615-9167-2_13
  15. Hubina, 2004, The effect of gender and age on growth hormone replacement in growth hormone-deficient patients., Horm Metab Res, 36, 247, 10.1055/s-2004-814458 · doi:10.1055/s-2004-814458
  16. Halse, 1981, Total and non-dialyzable urinary hydroxyproline in acromegalics and control subjects., Acta Endocrinol, 96, 451, 10.1530/acta.0.0960451 · doi:10.1530/acta.0.0960451
  17. Fredstorp, 1993, The short and long-term effects of octreotide on calcium homeostasis in patients with acromegaly., Clin Endocrinol (Oxf), 39, 331, 10.1111/j.1365-2265.1993.tb02373.x · doi:10.1111/j.1365-2265.1993.tb02373.x
  18. Brambilla, 1989, α2-Adrenoceptor sensitivity in anorexia nervosa: GH response to clonidine or GHRH stimulation, Biol Psychiatry., 25, 256, 10.1016/0006-3223(89)90173-X · doi:10.1016/0006-3223(89)90173-x
  19. De Marinis, 2000, Effects of galanin on growth hormone and prolactin secretion in anorexia nervosa., Metabolism, 49, 155, 10.1016/S0026-0495(00)91091-6 · doi:10.1016/s0026-0495(00)91091-6
  20. Tamai, 1990, Effect of cholinergic muscarinic receptor blockade on human growth hormone (GH)-releasing hormone-(1–44)-induced-GH secretion in anorexia nervosa., J Clin Endocrinol Metab, 70, 738, 10.1210/jcem-70-3-738 · doi:10.1210/jcem-70-3-738
  21. Gianotti, 1998, Effects of β-adrenergic agonists and antagonists on the growth hormone response to growth hormone-releasing hormone in anorexia nervosa., Biol Psychiatry, 43, 181, 10.1016/S0006-3223(97)00014-0 · doi:10.1016/s0006-3223(97)00014-0
  22. Plata-Salaman, 1999, Leptin, anorexia nervosa, and anorexia of acute and chronic disease., Nutrition, 15, 943
  23. Muller, 1992, Undernutrition and pituitary function: relevance to the pathophysiology of some neuroendocrine alterations of anorexia nervosa., J Endocrinol, 132, 327, 10.1677/joe.0.1320327 · doi:10.1677/joe.0.1320327
  24. Grinspoon, 2003, Effects of recombinant human insulin-like growth factor (IGF)-I and estrogen administration on IGF-I, IGF binding protein (IGFBP)-2, and IGFBP-3 in anorexia nervosa: a randomized-controlled study., J Clin Endocrinol Metab, 88, 1142, 10.1210/jc.2002-021402 · doi:10.1210/jc.2002-021402

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Metadata

Authors
Giustina, A., Mazziotti, G., & Canalis, E.
Venue
Endocrine Reviews
Publisher
The Endocrine Society
Published
2008-08-01
Volume
29
Issue
5
Pages
535-559
ISSN
  • 0163-769X (ISSN-L)
  • 1945-7189
DOI
10.1210/er.2007-0036
OpenAlex
W2118793476
Cited by
914
References
479
FWCI
37.91
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Growth Hormone, Insulin-Like Growth Factors, and the Skeleton. https://app.cochat.ai/papers/10.1210/er.2007-0036
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Giustina, A., Mazziotti, G., & Canalis, E. (2008). Growth Hormone, Insulin-Like Growth Factors, and the Skeleton. Endocrine Reviews. https://doi.org/10.1210/er.2007-0036

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