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Brain refractive index measured in vivo with high-NA defocus-corrected full-field OCT and consequences for two-photon microscopy
Open accessAbstract
Two-photon laser scanning microscopy (2PLSM) is an important tool for in vivo tissue imaging with sub-cellular resolution, but the penetration depth of current systems is potentially limited by sample-induced optical aberrations. To quantify these, we measured the refractive index n' in the somatosensory cortex of 7 rats in vivo using defocus optimization in full-field optical coherence tomography (ff-OCT). We found n' to be independent of imaging depth or rat age. From these measurements, we calculated that two-photon imaging beyond 200 µm into the cortex is limited by spherical aberration, indicating that adaptive optics will improve imaging depth.
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Cited by
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Horton, N. G., Wang, K., Kobat, D., Clark, C. G., Wise, F. W., Schaffer, C. B., & Xu, C. (2013) · Nature Photonics · doi:10.1038/nphoton.2012.336 · Cited by 1,505
Wu, X., Jiang, Y., Rommelfanger, N. J., Yang, F., Zhou, Q., Yin, R., Liu, J., Cai, S., Ren, W., Shin, A., et al. (2022) · Nature Biomedical Engineering · doi:10.1038/s41551-022-00862-w · Cited by 222
A coaxial optrode as multifunction write-read probe for optogenetic studies in non-human primates
Ozden, I., Wang, J., Lu, Y., May, T., Lee, J., Goo, W., O'Shea, D. J., Kalanithi, P., Diester, I., Diagne, M., et al. (2013) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2013.06.011 · Cited by 97
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Liske, H., Qian, X., Anikeeva, P., Deisseroth, K., & Delp, S. (2013) · Scientific Reports · doi:10.1038/srep03110 · Cited by 42
Adaptive Optical Two-Photon Microscopy for Surface-Profiled Living Biological Specimens
Yamaguchi, K., Otomo, K., Kozawa, Y., Tsutsumi, M., Inose, T., Hirai, K., Sato, S., Nemoto, T., & Uji-i, H. (2021) · ACS Omega · doi:10.1021/acsomega.0c04888 · Cited by 19
Metadata
- Authors
- Binding, J., Ben Arous, J., Léger, J.-F., Gigan, S., Boccara, C., & Bourdieu, L.
- Venue
- Optics Express
- Publisher
- Optica Publishing Group
- Published
- 2011-02-28
- Volume
- 19
- Issue
- 6
- Pages
- 4833
- ISSN
- 1094-4087 (ISSN-L)
- OpenAlex
- W1996925654
- Cited by
- 173
- References
- 0
- FWCI
- 7.84
- Type
- journal article
- Language
- en
- Open access
- gold
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- The paper
- Binding, J., Ben Arous, J., Léger, J.-F., Gigan, S., Boccara, C., & Bourdieu, L. (2011). Brain refractive index measured in vivo with high-NA defocus-corrected full-field OCT and consequences for two-photon microscopy. Optics Express. https://doi.org/10.1364/oe.19.004833
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