The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Proposed method for molecular optical imaging
Abstract
We can resolve multiple discrete features within a focal region of m spatial dimensions by first isolating each on the basis of n >/= 1 unique optical characteristics and then measuring their relative spatial coordinates. The minimum acceptable separation between features depends on the point-spread function in the (m + n)d-dimensional space formed by the spatial coordinates and the optical parameters, whereas the absolute spatial resolution is determined by the accuracy to which the coordinates can be measured. Estimates of each suggest that near-field fluorescence excitation microscopy/spectroscopy with molecular sensitivity and spatial resolution is possible.
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Citations
Cites
Theory of Diffraction by Small Holes
Bethe, H. A. (1944) · Physical Review · doi:10.1103/physrev.66.163 · Cited by 2,607
Single Molecules Observed by Near-Field Scanning Optical Microscopy
Betzig, E., & Chichester, R. J. (1993) · Science · doi:10.1126/science.262.5138.1422 · Cited by 1,262
Self-citationSingle pentacene molecules detected by fluorescence excitation in a p-terphenyl crystal
Orrit, M., & Bernard, J. (1990) · Physical Review Letters · doi:10.1103/physrevlett.65.2716 · Cited by 1,042
Near-Field Spectroscopy of the Quantum Constituents of a Luminescent System
Hess, H. F., Betzig, E., Harris, T. D., Pfeiffer, L. N., & West, K. W. (1994) · Science · doi:10.1126/science.264.5166.1740 · Cited by 513
Self-citationMechanical detection of magnetic resonance
Rugar, D., Yannoni, C. S., & Sidles, J. A. (1992) · Nature · doi:10.1038/360563a0 · Cited by 395
Position measurement with a resolution and noise-limited instrument
Bobroff, N. (1986) · Review of Scientific Instruments · doi:10.1063/1.1138619 · Cited by 375
Ambrose, W. P., Basché, T., & Moerner, W. E. (1991) · The Journal of Chemical Physics · doi:10.1063/1.461392 · Cited by 350
Noninductive detection of single-proton magnetic resonance
Sidles, J. A. (1991) · Applied Physics Letters · doi:10.1063/1.104757 · Cited by 267
Stark effect on single molecules in a polymer matrix
Orrit, M., Bernard, J., Zumbusch, A., & Personov, R. I. (1992) · Chemical Physics Letters · doi:10.1016/0009-2614(92)86000-8 · Cited by 161
Optical modification of a single impurity molecule in a solid
Basché, T., & Moerner, W. E. (1992) · Nature · doi:10.1038/355335a0 · Cited by 153
Cited by
Hell, S. W. (2007) · Science · doi:10.1126/science.1137395 · Cited by 2,967
Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution
Chen, B.-C., Legant, W. R., Wang, K., Shao, L., Milkie, D. E., Davidson, M. W., Janetopoulos, C., Wu, X. S., Hammer, J. A., Liu, Z., et al. (2014) · Science · doi:10.1126/science.1257998 · Cited by 1,919
Self-citationMichalet, X. (2010) · Physical Review E · doi:10.1103/physreve.82.041914 · Cited by 721
Localization Accuracy in Single-Molecule Microscopy
Ober, R. J., Ram, S., & Ward, E. S. (2004) · Biophysical Journal · doi:10.1016/s0006-3495(04)74193-4 · Cited by 587
Quantum theory of superresolution for two incoherent optical point sources
Tsang, M., Nair, R., & Lu, X.-M. (2016) · Physical Review X · doi:10.1103/physrevx.6.031033 · Cited by 482
Metadata
- Authors
- Betzig, E.
- Venue
- Optics Letters
- Publisher
- Optica Publishing Group
- Published
- 1995-02-01
- Volume
- 20
- Issue
- 3
- Pages
- 237
- ISSN
- 0146-9592 (ISSN-L)
- 1539-4794
- OpenAlex
- W1995413508
- Cited by
- 444
- References
- 10
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
