Noninvasive, On-Line Monitoring of the Biotransformation by Yeast of Glucose to Ethanol Using Dispersive Raman Spectroscopy and Chemometrics
Abstract
We describe the first application of dispersive Raman spectroscopy using a diode laser exciting at 780 nm and a charge-coupled device (CCD) detector to the noninvasive, on-line determination of the biotransformation by yeast of glucose to ethanol. Software was developed which automatically removed the effects of cosmic rays and other noise, normalized the spectra to an invariant peak, then removed the “baseline” arising from interference by fluorescent impurities, to obtain the “true” Raman spectra. Variable selection was automatically performed on the parameters of relevant Raman peaks (height, width, position of top and center, area and skewness), and a small subset used as the input to cross-validated models based on partial least-squares (PLS) regression. The multivariate calibration models so formed were sufficiently robust to be able to predict the concentration of glucose and ethanol in a completely different fermentation with a precision better than 5%. Dispersive Raman spectroscopy, when coupled with the appropriate chemometrics, is a very useful approach to the noninvasive, on-line determination of the progress of microbial fermentations.
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Fluorescence spectroscopy is flexible for monitoring a number of analytes via direct or indirect correlations.
“The flexibility of fluorescence spectroscopy is well‐reported for the monitoring of a number of analytes, via direct or indirect correlations, such as proteins, vitamins, co‐enzymes, glucose, ethanol, ATP, pyruvate, nitrate, or succinate (Shaw et al., 1999; Ulber et al., 2003; Hantelmann et al., 2006; Glindkamp et al., 2009; Ranzan et al., 2012).”
From Perspectives of fluorescence spectroscopy for online monitoring in microalgae industry (2022) · cites this paper as Shaw et al., 1999
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- Authors
- Shaw, A. D., Kaderbhai, N., Jones, A., Woodward, A. M., Goodacre, R., Rowland, J. J., & Kell, D. B.
- Affiliations
- Aberystwyth University (GB)
- Venue
- Applied Spectroscopy
- Publisher
- SAGE Publications
- Published
- 1999-11
- Volume
- 53
- Issue
- 11
- Pages
- 1419-1428
- ISSN
- 0003-7028 (ISSN-L)
- 1943-3530
- OpenAlex
- W2062294580
- Cited by
- 84
- References
- 69
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 7 · 2018: 5 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 7 · 2013: 3 · 2012: 4
- FWCI
- 2.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Applied Spectroscopy (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Analytical Chemistry › Spectroscopy and Chemometric Analyses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
- Physical Sciences › Environmental Science › Waste Management and Disposal › Water Quality Monitoring and Analysis
- Keywords
- yeast fermentation, partial least squares regression, chemometrics, feature selection, multivariate calibration, spectral baseline correction
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