Thrombospondin 1 and Its Diverse Roles as a Regulator of Extracellular Matrix in Fibrotic Disease
Open accessAbstract
Thrombospondin 1 (TSP1) is a matricellular extracellular matrix protein that has diverse roles in regulating cellular processes important for the pathogenesis of fibrotic diseases. We will present evidence for the importance of TSP1 control of latent transforming growth factor beta activation in renal fibrosis with an emphasis on diabetic nephropathy. Other functions of TSP1 that affect renal fibrosis, including regulation of inflammation and capillary density, will be addressed. Emerging roles for TSP1 N-terminal domain regulation of collagen matrix assembly, direct effects of TSP1–collagen binding, and intracellular functions of TSP1 in mediating endoplasmic reticulum stress responses in extracellular matrix remodeling and fibrosis, which could potentially affect renal fibrogenesis, will also be discussed. Finally, we will address possible strategies for targeting TSP1 functions to treat fibrotic renal disease.
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CellChat predicted strong incoming SDC4-mediated signals through THBS1, TNXB, TNC, COL4A, and ANGPTL4.
“CellChat predicted strong incoming SDC4-mediated signals through THBS1, TNXB, TNC, COL4A, and ANGPTL4 (Figure S5J), all of which are involved in ECM regulation.54,55,56”
From Cellular senescence in human liver under normal aging and cancer (2026) · cites this paper as [55]
THBS1, TNXB, TNC, COL4A, and ANGPTL4 are involved in ECM regulation.
“all of which are involved in ECM regulation.54,55,56”
From Cellular senescence in human liver under normal aging and cancer (2026) · cites this paper as [55]
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- Authors
- Murphy-Ullrich, J. E.
- Affiliations
- University of Alabama at Birmingham (US)
- Corresponding author
- Murphy-Ullrich, Joanne E.
- Venue
- Journal of Histochemistry & Cytochemistry
- Publisher
- SAGE Publications
- Published
- 2019-05-22
- Volume
- 67
- Issue
- 9
- Pages
- 683-699
- ISSN
- 0022-1554 (ISSN-L)
- 1551-5044
- PMC
- PMC6713974
- OpenAlex
- W2946132178
- Cited by
- 104
- References
- 182
- Citations by year
- 2026: 10 · 2025: 23 · 2024: 16 · 2023: 14 · 2022: 18 · 2021: 16 · 2020: 6 · 2018: 1
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Histochemistry & Cytochemistry (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- national institutes of health (NIH grants 1R01 CA175012 and 1R01 EY027924)
- university of alabama at birmingham (Alabama Drug Discovery Alliance)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connective Tissue Growth Factor Research
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Keywords
- thrombospondin-1, extracellular matrix, renal fibrosis, diabetic nephropathy, latent TGF-beta activation, matricellular proteins, inflammation, capillary density, endoplasmic reticulum stress, extracellular matrix remodeling
- MeSH terms
- Animals, Collagen, Diabetic Nephropathies, Extracellular Matrix, Fibrosis, Humans, Kidney, Transforming Growth Factor beta, Thrombospondin 1, Renal Insufficiency, Chronic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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