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Inflammasome Components NALP 1 and 3 Show Distinct but Separate Expression Profiles in Human Tissues Suggesting a Site-specific Role in the Inflammatory Response
Open accessAbstract
Several autoinflammatory disorders such as Muckle-Wells syndrome are characterized by mutations in the NALP3/cryopyrin gene. NALP3 and NALP1 proteins can assemble to inflammasomes that activate caspase-1, resulting in the processing of proinflammatory cytokines IL-1β and IL-18. The present study was designed to determine which cells and tissues express NALP1 and NALP3. Monoclonal antibodies were developed and their use revealed distinct distribution profiles of NALP1 and NALP3. Granulocytes, monocytes (very weakly), dendritic cells, and B and T cells all express NALP1 and NALP3. Highest levels of NALP1 are found in T cells and Langerhans cells. Furthermore, NALP1 is present in glandular epithelial structures such as stomach, gut, lung, and, surprisingly, in neurons and testis. In contrast to NALP1, NALP3 shows a more restricted tissue distribution with expression mainly in non-keratinizing epithelia in the oropharynx, esophagus, and ectocervix. Moreover, NALP3 expression is found in the urothelial layer in the bladder. Likewise, a difference in subcellular distribution between NALP1 and NALP3 is observed because NALP1 is localized mainly in the nucleus, whereas NALP3 is predominantly cytoplasmic. We propose that the presence of NALP3 in epithelial cells lining the oral and genital tracts allows the rapid sensing of invading pathogens, thereby triggering an innate immune response.
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“several studies have characterized inflammasomes in neurons (de Rivero Vaccari et al, 2009;Kummer et al, 2007), which are capable of producing IL-1β (de Rivero Vaccari et al, 2009).”
From Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders (2017) · cites this paper as Kummer et al, 2007
Citations
Cites
Martinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00599-3 · Cited by 6,066
Self-citationGout-associated uric acid crystals activate the NALP3 inflammasome
Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A., & Tschopp, J. (2006) · Nature · doi:10.1038/nature04516 · Cited by 5,326
Self-citationCryopyrin activates the inflammasome in response to toxins and ATP
Mariathasan, S., Weiss, D. S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., Lee, W. P., Weinrauch, Y., Monack, D. M., & Dixit, V. M. (2006) · Nature · doi:10.1038/nature04515 · Cited by 3,080
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
Mariathasan, S., Newton, K., Monack, D. M., Vucic, D., French, D. M., Lee, W. P., Roose-Girma, M., Erickson, S. L., & Dixit, V. M. (2004) · Nature · doi:10.1038/nature02664 · Cited by 1,864
Agostini, L., Martinon, F., Burns, K., McDermott, M. F., Hawkins, P. N., & Tschopp, J. (2004) · Immunity · doi:10.1016/s1074-7613(04)00046-9 · Cited by 1,768
Self-citationHoffman, H. M., Mueller, J. L., Broide, D. H., Wanderer, A. A., & Kolodner, R. D. (2001) · Nature Genetics · doi:10.1038/ng756 · Cited by 1,679
Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3
Kanneganti, T., Özören, N., Body–Malapel, M., Amer, A. O., Park, J., Franchi, L., Whitfield, J. R., Barchet, W., Colonna, M., Vandenabeele, P., et al. (2006) · Nature · doi:10.1038/nature04517 · Cited by 1,149
NOD-LRR PROTEINS: Role in Host-Microbial Interactions and Inflammatory Disease
Inohara, N., Chamaillard, M., McDonald, C., & Núñez, G. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133347 · Cited by 1,019
Interleukin-1 and neuronal injury
Allan, S. M., Tyrrell, P. J., & Rothwell, N. J. (2005) · Nature Reviews Immunology · doi:10.1038/nri1664 · Cited by 992
Sutterwala, F. S., Ogura, Y., Szczepanik, M., Lara-Tejero, M., Lichtenberger, G. S., Grant, E. P., Bertin, J., Coyle, A. J., Galán, J. E., Askenase, P. W., et al. (2006) · Immunity · doi:10.1016/j.immuni.2006.02.004 · Cited by 980
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Zhang, J., Xie, D., Jiao, D., Zhou, S. Y., Liu, S., Ju, Z., Hu, L., Li, Q., Yao, C., & Chen, Z. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e32688 · Cited by 9
Ramos, Y. Á. L., Pietrobon, A. J., Teixeira, F. M. E., Aoki, V., Sato, M. N., & Orfali, R. L. (2025) · Anais Brasileiros de Dermatologia · doi:10.1016/j.abd.2025.501136 · Cited by 7
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Ishabiyi, F. O., Ogidi, J. O., Olukade, B. A., Amorha, C. C., El‐Sharkawy, L. Y., Okolo, C. C., Adeniyi, T. M., Atasie, N. H., Ibrahim, A., & Balogun, T. A. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221020 · Cited by 8
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Minas, A., Costa, L. V. S., Miyazaki, M. A., & Antoniassi, M. P. (2023) · American Journal of Reproductive Immunology · doi:10.1111/aji.13734 · Cited by 7
Li, D., Hodges, R. R., AukrustNaqvi, M., Bair, J. A., Bispo, P. J. M., Gilmore, M. S., Gregory-Ksander, M. S., & Dartt, D. A. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1265471 · Cited by 7
Zhang, K., Tao, P., Liu, J., Wang, Q., Ge, S., & Ning, Z. (2017) · Acta Veterinaria Hungarica · doi:10.1556/004.2017.038 · Cited by 7
“To date, research concerning the NLRP3 inflammasome has been concentrated on humans, mice, pigs and chickens (Anderson et al., 2004; Kummer et al., 2007; Tohno et al., 2011; Huang et al., 2014; Ye et al., 2015).”
BackgroundBeutler, B. (2008) · Current topics in microbiology and immunology · doi:10.1007/978-3-540-75203-5 · Cited by 7
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“Activation of the canonical pathway begins with activa - tion of transcription factor NF-κB induced by the binding regulating the secretion of IL-1β, and blocking the expres - sion of NLRP3, AIM2, ASC, and caspase-1 [32, 37, 43 – 48 ].”
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Farooqui, A. A. (2016) · Springer eBooks · doi:10.1007/978-3-319-15889-1_7 · Cited by 6
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BackgroundElgohary, S., Eissa, R. A., & Tayebi, H. M. E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241814254 · Cited by 6
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Kauppinen, A. (2017) · Springer eBooks · doi:10.1007/978-3-319-64597-1_107-1 · Cited by 7
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BackgroundBi, F., Bai, Y. M., Zhang, Y., Shi, M., & Liu, W. (2022) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2022.11707 · Cited by 7
Suwanmanee, S., Ghimire, S., Edwards, J. M., & Griffin, D. E. (2023) · Viruses · doi:10.3390/v15020260 · Cited by 9
“Expression of inflammasome components is cell-type specific with myeloid and epithelial cells serving as important sites during viral infections [25,26].”
BackgroundKodi, T., Nandakumar, K., & Kishore, A. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05932-7 · Cited by 6
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Пирожков, С. В., Terebilina, N. N., & Litvitskiy, P. F. (2018) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro201811812181 · Cited by 6
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Thakur, V., Ratho, R. K., Singh, M. P., Chawla, Y. K., & Taneja, S. (2022) · Current Microbiology · doi:10.1007/s00284-021-02736-x · Cited by 5
“NLRP1 is known to be predominantly expressed by hematopoietic cells and showing the highest expression in human skin in psoriasis [21] whereas NLRC4 modulates the dendritic cells for generating the robust and protective T-cell response in influenza-A virus (IAV) infection [22].”
BackgroundPathogenicity Mechanism of Candida albicans
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“Surprisingly, NLRP3 is strongly expressed in nonkeratinizing epithelia, such as the oral cavity and throat [151], suggesting a possible role for NLRP3 in parasitic recognition in oral epithelial cells, which is supported by studies showing increased IL- I and IL- I8 levels in response to C.”
Wang, H., Kan, W., Feng, Y., Feng, L., Yang, Y., Chen, P., Xu, J.-J., Si, T., Zhang, L., Wang, G., et al. (2021) · World Journal of Psychiatry · doi:10.5498/wjp.v11.i12.1191 · Cited by 5
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Carneiro, L. A. M., Fritz, J. H., Kufer, T. A., Travassos, L. H., Benkő, S., & Philpott, D. J. (2009) · EcoSal Plus · doi:10.1128/ecosalplus.8.8.3 · Cited by 5
Whitehead, L., & Brown, G. D. (2017) · Wiley-VCH eBooks · doi:10.1002/9783527692156.ch8 · Cited by 6
Pérez, D. C., Hernandez-Franco, J. F., & HogenEsch, H. (2026) · Scientific Reports · doi:10.1038/s41598-025-34660-6 · Cited by 4
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AG, H., M, S., & Chitra, V. (2019) · Asian Journal of Pharmaceutical and Clinical Research · doi:10.22159/ajpcr.2019.v12i3.29307 · Cited by 4
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BackgroundYurtdas, C., Zortul, H., Yılmaz, B., & Arıcıoğlu, F. (2023) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2023.100462 · Cited by 6
Zhou, Z. Y., Zhou, Y., Liu, W., & Dai, J. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1148430 · Cited by 4
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BackgroundLin, T., Chiu, Y., Lin, C., Chen, Y., Lin, W., Wu, Y., Chang, K., Chen, C., & Lee‐Chen, G. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1437138 · Cited by 3
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Tiong, S. Q., Mohgan, R., Quek, J. Y., Liew, J. Y. S., Wong, G. Y. S., Thang, Z. Q., Chan, Z. L., Gan, S. Y., & Chan, E. W. L. (2025) · Neurology Research International · doi:10.1155/nri/8948290 · Cited by 3
Chen, Z., Jin, H., HOU, Y., Wang, B., Chen, C., Yang, Z., Ding, D., Zuo, Y., & Ren, S. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2776 · Cited by 3
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Çıracı, C. (2017) · InTech eBooks · doi:10.5772/intechopen.70484 · Cited by 3
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BackgroundA variant allele of the Mediterranean‐fever gene increases the severity of gout
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Xu, C., Qian, W., Wu, Y., Chen, X., Li, Z., & Xu, D. (2025) · Journal of Molecular Histology · doi:10.1007/s10735-025-10562-9 · Cited by 2
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Tozetto‐Mendoza, T. R., Mendes-Corrêa, M. C., Linhares, I. M., Raymundi, V. D. C., Paião, H. G. O., Barbosa, E. M. G., Luna-Muschi, A., Honorato, L., Correa, G. F., da Costa, A. C., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-38095-9 · Cited by 2
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Taïeb, A., Peroni, A., Girolomoni, G., Kemp, E. H., Weetman, A. P., Gawkrodger, D. J., Poole, I. C. L., & Norris, D. A. (2010) · Springer eBooks · doi:10.1007/978-3-540-69361-1_28 · Cited by 2
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Ungerbäck, J. (2012) · Cited by 1
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Eklund, D. (2013) · Linköping University Electronic Press eBooks · doi:10.3384/diss.diva-100890 · Cited by 1
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Arama, C. (2012) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
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Brincks, E. L. (2010) · doi:10.17077/etd.2lf132yd
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Strand, M.-L. (2012) · Figshare
Marcon, R. (2013) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
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Verma, D. (2009)
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Kastbom, A. (2007)
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Bukhari, E. (2009) · eScholarship@McGill (McGill) · doi:10.82308/26380
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Rajamäki, K. (2015) · Työväentutkimus Vuosikirja
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Frew, B. C. (2012) · TSpace (University of Toronto)
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Liang, Q., Ge, J., & Jin, X. (2016) · Springer eBooks · doi:10.1007/978-3-319-30079-5_4
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Scull, M. A. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/9k4z-5e11
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Moro, C., & Chess‐Williams, R. (2017) · e-publications@bond (Bond University) · doi:10.4225/57/5b29dcd792808
“Additionally, a range of immune cells are also present in the lamina propria, such as mast cells and dendritic cells (Christmas and Rode, 1991, Gardiner et al., 1986, Kummer et al., 2007, Yu and Hill, 2011).”
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Velummailum, R. (2011) · TSpace (University of Toronto)
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Neiman-Zenevich, J. (2017) · TSpace (University of Toronto)
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Alimohammadi, M. (2009) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
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Roa, M. E. G. V., Cambui, R. A. G., Yamada, S. M., Gonçalves, L. D., Lara, A. N., Leal, V. N. C., & Pontillo, A. (2024) · Research Square · doi:10.21203/rs.3.rs-3715397/v1
Metadata
- Authors
- Kummer, J. A., Broekhuizen, R., Everett, H., Agostini, L., Kuijk, L., Martinon, F., Bruggen, R. V., & Tschopp, J.
- Affiliations
- University Medical Center Utrecht (NL)
- University of Lausanne (CH)
- Corresponding author
- Tschopp, Jürg
- Venue
- Journal of Histochemistry & Cytochemistry
- Publisher
- SAGE Publications
- Published
- 2007-05
- Volume
- 55
- Issue
- 5
- Pages
- 443-452
- ISSN
- 0022-1554 (ISSN-L)
- 1551-5044
- OpenAlex
- W2043091577
- Cited by
- 531
- References
- 34
- Citations by year
- 2026: 9 · 2025: 20 · 2024: 25 · 2023: 44 · 2022: 24 · 2021: 34 · 2020: 21 · 2019: 40 · 2018: 27 · 2017: 24 · 2016: 23 · 2015: 38 · 2014: 25 · 2013: 36 · 2012: 30
- FWCI
- 7.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Histochemistry & Cytochemistry (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Keywords
- NALP1, NLRP3, inflammasome, tissue distribution, autoinflammatory disease, Muckle-Wells syndrome, caspase-1, IL-1β, IL-18, Langerhans cells, epithelial cells, subcellular localization, innate immune response, mucosal immunity
- MeSH terms
- NLR Proteins, NLR Family, Pyrin Domain-Containing 3 Protein, Antibodies, Monoclonal, Carrier Proteins, Cell Line, Humans, Immunohistochemistry, Inflammation, Organ Specificity, Immunoblotting, Adaptor Proteins, Signal Transducing, Apoptosis Regulatory Proteins
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