Effectiveness of Physical Exercise in Older Adults With Mild to Moderate Depression
Open accessAbstract
PURPOSE We sought to compare the effectiveness of physical exercise with that of treatment with antidepressant drugs routinely used in clinical practice, in terms of decreasing depressive symptomatology in patients aged ≥65 years who present with clinical criteria of a depressive episode. METHODS We conducted a randomized clinical trial in a primary care setting. A total of 347 patients aged ≥65 years with a clinically significant depressive episode were randomized to participation in a supervised physical exercise program or to receive antidepressant treatment by their general practitioners. RESULTS Intention-to-treat analysis showed that the cumulative incidence of improvement in depressive symptomatology (Montgomery-Åsberg Depression Rating Scale score <10) in the physical activity (PA) group after 1 month was not significantly different from that in the antidepressant treatment (AT) group. However, the proportion of those who showed improvement was significantly greater (P <.01) in the AT group (60.6% and 49.7%) compared to the PA group (45.6% and 32.9%) at the end of 3 and 6 months, respectively. The number of withdrawals was greater in the PA group (39.2% and 58.2%) compared to the AT group (22.6% and 40.0%) at 3 and 6 months, respectively, yet the proportion of participants with adverse side effects was greater in the AT group (8.9% vs 22.5%; P = .007). CONCLUSION Although improvement was initially similar in both treatment groups, AT was superior in the medium term, despite giving rise to a greater number of adverse effects.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In one study, 58% and 40% of participants withdrew from the exercise and antidepressant groups, respectively.
“In this study, 58% and 40% of participants withdrew from the exercise and antidepressant groups, respectively.38”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
International physical activity questionnaire: 12-country reliability and validity
CRAIG, C. L., MARSHALL, A. L., SJ??STR??M, M., BAUMAN, A. E., BOOTH, M. L., AINSWORTH, B. E., PRATT, M., EKELUND, U., YNGVE, A., SALLIS, J. F., et al. (2003) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000078924.61453.fb · Cited by 21,619 · see citing works
A new depression scale designed to be sensitive to change
Montgomery, S. A., & Åsberg, M. (1979) · British Journal of Psychiatry · doi:10.1192/bjp.134.4.382 · Cited by 13,962 · see citing works
EQ-SD: a measure of health status from the EuroQol Group
Rabin, R., & Charro, F. D. (2001) · Annals of Medicine · doi:10.3109/07853890109002087 · Cited by 5,613 · see citing works
Concurrent and Predictive Validity of a Self-reported Measure of Medication Adherence
Morisky, D. E., Green, L. W., & Levine, D. M. (1986) · Medical Care · doi:10.1097/00005650-198601000-00007 · Cited by 5,304 · see citing works
Depression, chronic diseases, and decrements in health: results from the World Health Surveys
Moussavi, S., Chatterji, S., Verdes, E., Tandon, A., Patel, V., & Ustun, B. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61415-9 · Cited by 4,070 · see citing works
Exercise: a behavioral intervention to enhance brain health and plasticity
Cotman, C. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02143-4 · Cited by 2,739 · see citing works
Cooney, G. M., Dwan, K., Greig, C. A., Lawlor, D. A., Rimer, J., Waugh, F. R., McMurdo, M., & Mead, G. E. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004366.pub6 · Cited by 1,834 · see citing works
Effects of exercise training on older patients with major depression
Blumenthal, J. A., Babyak, M. A., Moore, K. A., Craighead, W. E., Herman, S., Khatri, P., Waugh, R., Napolitano, M. A., Forman, L. M., Appelbaum, M., et al. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.19.2349 · Cited by 1,277 · see citing works
Exercise and Pharmacotherapy in the Treatment of Major Depressive Disorder
Blumenthal, J. A., Babyak, M. A., Doraiswamy, P. M., Watkins, L., Hoffman, B. M., Barbour, K. A., Herman, S., Craighead, W. E., Brosse, A. L., Waugh, R., et al. (2007) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318148c19a · Cited by 1,019 · see citing works
Exercise for the Treatment of Depression
Knapen, J., Vancampfort, D., Schoubs, B., Probst, M.-T., Sienaert, P. A., Haake, P., Peuskens, J., & Pieters, G. (2009) · The Open Complementary Medicine Journal · doi:10.2174/1876391x00901010078 · Cited by 911 · see citing works
Dvořák, J., McCrory, P. R., Aubry, M., Molloy, M. J., & Engebretsen, L. (2009) · British Journal of Sports Medicine · doi:10.1136/bjsm.2009.059360 · Cited by 907 · see citing works
Cooney, G. M., Dwan, K., Greig, C. A., Lawlor, D. A., Rimer, J., Waugh, F. R., McMurdo, M., & Mead, G. E. (2014) · Advances in Psychiatric Treatment · doi:10.1192/apt.20.1.2 · Cited by 895 · see citing works
Management of Depression in Older Adults: A Review
Kok, R. M., & Reynolds, C. F. (2017) · JAMA · doi:10.1001/jama.2017.5706 · Cited by 890 · see citing works
61 Physical inactivity: the biggest public health problem of the 21st Century
Blair, S. N. (2007) · Journal of science and medicine in sport · doi:10.1016/s1440-2440(07)70066-x · Cited by 753 · see citing works
Effects of exercise and physical activity on depression
Dinas, P. C., Koutedakis, Y., & Flouris, A. D. (2010) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-010-0633-9 · Cited by 506 · see citing works
Taylor, W. D. (2014) · New England Journal of Medicine · doi:10.1056/nejmcp1402180 · Cited by 403 · see citing works
Lobo, A., Chamorro, L., Luque, A., Dal-Ré, R., Badia, X., & Baró, E. (2002) · Medicina Clínica · doi:10.1016/s0025-7753(02)72429-9 · Cited by 362 · see citing works
Antidepressant effects of exercise: Evidence for an adult-neurogenesis hypothesis?
Ernst, C., Olson, A. K., Pinel, J. P. J., Lam, R. W., & Christie, B. R. (2006) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0610 · Cited by 322 · see citing works
de Oliveira, L. D. S. S. C. B., de Souza, É. C., Rodrigues, R. A. S., Fett, C. A., & Biagini, Â. P. (2019) · Trends in Psychiatry and Psychotherapy · doi:10.1590/2237-6089-2017-0129 · Cited by 314 · see citing works
Blumenthal, J. A., Sherwood, A., Babyak, M. A., Watkins, L. L., Smith, P. J., Hoffman, B. M., O'Hayer, C. V. F., Mabe, S., Johnson, J., Doraiswamy, P. M., et al. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.04.040 · Cited by 259 · see citing works
The effects of physical exercise on depressive symptoms among the aged: a systematic review
Sjösten, N., & Kivelä, S.-L. (2006) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1494 · Cited by 245 · see citing works
Grémeaux, V., Gayda, M., Lepers, R., Sosner, P., Juneau, M., & Nigam, A. (2012) · Maturitas · doi:10.1016/j.maturitas.2012.09.012 · Cited by 228 · see citing works
Schuch, F. B., Vancampfort, D., Rosenbaum, S., Richards, J., Ward, P. B., Veronese, N., Solmi, M., Cadore, E. L., & Stubbs, B. (2016) · Revista Brasileira de Psiquiatria · doi:10.1590/1516-4446-2016-1915 · Cited by 226 · see citing works
Catalán-Matamoros, D., Gómez‐Conesa, A., Stubbs, B., & Vancampfort, D. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.07.028 · Cited by 208 · see citing works
Acute and chronic effects of exercise on tissue sensitivity to glucocorticoids
Duclos, M., Gouarne, C., & Bonnemaison, D. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00108.2002 · Cited by 193 · see citing works
del Valle, A. S., Martínez-García, R., González, O. M., & Márquez, S. (2010) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2010.10.005 · Cited by 154 · see citing works
Treatment of minor depression in older adults: A pilot study comparing sertraline and exercise
Brenes, G. A., Williamson, J. D., Messier, S. P., Rejeski, W. J., Pahor, M., Ip, E. H., & Penninx, B. W. J. H. (2006) · Aging & Mental Health · doi:10.1080/13607860600736372 · Cited by 133 · see citing works
the DEP-EXERCISE Group, & Hidalgo, J. L.-T. (2019) · BMC Psychiatry · doi:10.1186/s12888-018-1982-6 · Cited by 119 · see citing works
Self-citationMiller, K. J., Mesagno, C., McLaren, S., Grace, F., Yates, M. W., & Gomez, R. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.02145 · Cited by 105 · see citing works
Exercise and Depressive Symptoms in Older Adults: A Systematic Meta-Analytic Review
Rhyner, K. T., & Watts, A. (2016) · Journal of Aging and Physical Activity · doi:10.1123/japa.2015-0146 · Cited by 85 · see citing works
Exercise in the treatment of major depression: A systematic review grading the quality of evidence
Danielsson, L., Noras, A. M., Waern, M., & Carlsson, J. (2013) · Physiotherapy Theory and Practice · doi:10.3109/09593985.2013.774452 · Cited by 84 · see citing works
Blumenthal, J. A., Smith, P. J., & Hoffman, B. M. (2012) · ACSMʼs Health & Fitness Journal · doi:10.1249/01.fit.0000416000.09526.eb · Cited by 81 · see citing works
Exercise in the treatment of depression
Greer, T. L., & Trivedi, M. H. (2009) · Current Psychiatry Reports · doi:10.1007/s11920-009-0071-4 · Cited by 66 · see citing works
Garfield, V., Llewellyn, C. H., & Meena Kumari, B. (2016) · Preventive Medicine Reports · doi:10.1016/j.pmedr.2016.09.006 · Cited by 65 · see citing works
Home-Based Physical Activity Program Improves Depression and Anxiety in Older Adults
Aguiñaga, S., Ehlers, D. K., Salerno, E. A., Fanning, J. T., Motl, R. W., & McAuley, E. (2018) · Journal of Physical Activity and Health · doi:10.1123/jpah.2017-0390 · Cited by 65 · see citing works
Beyond METs: types of physical activity and depression among older adults
Joshi, S., Mooney, S. J., Kennedy, G. J., Benjamin, E. O., Ompad, D. C., Rundle, A., Beard, J., & Cerdá, M. (2016) · Age and Ageing · doi:10.1093/ageing/afv164 · Cited by 61 · see citing works
Seo, J. Y., & Chao, Y. (2017) · Journal of Gerontological Nursing · doi:10.3928/00989134-20171024-01 · Cited by 34 · see citing works
Holmquist, S., Mattsson, S., Schéle, I., Nordström, P., & Nordström, A. (2017) · Depression and Anxiety · doi:10.1002/da.22638 · Cited by 30 · see citing works
Acute and Chronic Effects of Exercise on Tissue Sensitivity to Glucocorticoids.
Duclos, M., Gouarné, C., & Bonnemaison, D. (2003) · Cardiopulmonary Physical Therapy Journal · doi:10.1097/01823246-200314020-00013 · Cited by 28 · see citing works
Is Exercise an Efficacious Treatment for Depression? A Comment upon Recent Negative Findings
Schuch, F., & Fleck, M. P. D. A. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00020 · Cited by 27 · see citing works
Kim, D.-J. (2017) · Journal of Physical Therapy Science · doi:10.1589/jpts.29.744 · Cited by 24 · see citing works
Ejercicio físico y depresión en adultos mayores: una revisión sistemática
Villada, F. A. P., Vélez, E. F. A., & Baena, L. Z. (2013) · Revista Colombiana de Psiquiatría · doi:10.1016/s0034-7450(13)70007-6 · Cited by 14 · see citing works
Physical Activity and Exercise in Older Adults
Bherer, L. (2012) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780195394313.013.0018 · Cited by 11 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- Blumenthal JA, Smith PJ, Hoffman BM. Is exercise a viable treat- ment for depression? ACSMs Health Fit J. 2012; 16(4): 14-21.
- ANNALS OF FAMILY MEDICINE ✦ WWW.ANNFAMMED.ORG ✦ VOL. 19, NO. 4 ✦ JULY/AUGUST 2021
- Lobo A, Chamorro L, Luque A, Dal-Ré R, Badia X, Baró E; Grupo de Validación en Español de Escalas Psicométricas (GVEEP). [Validation of the Spanish versions of the Montgomery-Asberg depression and Hamilton anxiety rating scales]. Med Clin (Barc). 2002; 118(13): 493- 499. [Article in Spanish]
Cited by
Sorted by citations
Recchia, F., Leung, C. K., Chin, E. C., Fong, D. Y., Montero, D., Cheng, C. P., Yau, S. Y., & Siu, P. M. (2022) · British Journal of Sports Medicine · doi:10.1136/bjsports-2022-105964 · Cited by 117 · see citing works
Exercise as an antidepressant: exploring its therapeutic potential
Hwang, D.-J., Koo, J., Kim, T.-K., Jang, Y., Hyun, A.-H., Yook, J.-S., Yoon, C.-S., & Cho, J. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1259711 · Cited by 49 · see citing works
Zeng, L., Zhao, X., Yu, Y., Hu, T., Li, C., Wu, M., & Yang, F. (2023) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-023-04207-1 · Cited by 28 · see citing works
Zhao, H., Zhang, B., Liu, W., & Jiang, Y. (2024) · Current Psychology · doi:10.1007/s12144-024-05751-w · Cited by 19 · see citing works
Xu, X., Zheng, Y., Fang, J., Huang, J., Yang, X., Zhu, X., Liu, Y., Chen, L., & Wu, S. (2024) · Frontiers in Public Health · doi:10.3389/fpubh.2024.1301067 · Cited by 18 · see citing works
Maccarone, M. C., Caregnato, A., Regazzo, G., Carriero, A., Casellato, G., Finamoni, C., Jirillo, R., Laskova, O., Marigo, E., Sánchez, D. Y., et al. (2023) · European Journal of Translational Myology · doi:10.4081/ejtm.2023.11780 · Cited by 13 · see citing works
Elder abuse victimization, mental health, and protective factors
Yoon, S. (2024) · Aging & Mental Health · doi:10.1080/13607863.2024.2326992 · Cited by 12 · see citing works
Liu, D., Tian, Y., Liu, M., & Yang, S. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.02.110 · Cited by 12 · see citing works
Clegg, A. J., Hill, J. E., Mullin, D. S., Harris, C., Smith, C. J., Lightbody, C. E., Dwan, K., Cooney, G. M., Mead, G. E., & Watkins, C. L. (2026) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004366.pub7 · Cited by 12 · see citing works
Stroke: current state of the problem
Gusev, E. I., & Martynov, M. Y. (2024) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro20241241117 · Cited by 10 · see citing works
Zhao, X.-D., Oh, S.-S., Zhang, Z., & Wang, C. (2025) · Frontiers in Public Health · doi:10.3389/fpubh.2025.1554195 · Cited by 13 · see citing works
Yu, Y., Wang, H., Li, W., Guo, H., & Chen, Y. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1655192 · Cited by 11 · see citing works
Li, G., Ji, H., Jiang, Q., Cao, H., Wang, Z., & Liu, S. (2024) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2024.03.005 · Cited by 9 · see citing works
Li, L., Guan, X., Huang, Y., Qu, B., Yao, B., & Ding, H. (2024) · Sports Medicine and Health Science · doi:10.1016/j.smhs.2024.01.005 · Cited by 8 · see citing works
Effect of physical exercise on medical rehabilitation treatment of depression
Wang, J., & Li, Z. (2022) · Revista Brasileira de Medicina do Esporte · doi:10.1590/1517-8692202228032021_0483 · Cited by 7 · see citing works
Li, R., Wang, W., Guo, J., Liu, W., Huang, X., Qiao, Y., Jia, S., Tian, L., Zhou, J., & Wang, G. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.02.090 · Cited by 7 · see citing works
Huang, Y., Wu, Z., Lin, S., & Chen, X. (2023) · Molecular Medicine · doi:10.1186/s10020-023-00728-0 · Cited by 7 · see citing works
Sun, S., Chen, J., Zheng, M., Zhou, M., Xue, Y., Shen, Y., Hu, Y., Ni, K., Fan, Y., & Lv, B. (2024) · BMC Gastroenterology · doi:10.1186/s12876-024-03533-z · Cited by 7 · see citing works
Xu, Q., Fan, Y., Zhu, J., & Wang, X. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e36510 · Cited by 8 · see citing works
Lü, L., & He, P. (2024) · Frontiers in Public Health · doi:10.3389/fpubh.2024.1472445 · Cited by 6 · see citing works
Exercise as elixir to combat cardiovascular ageing
Feng, Z., Yuan, X., Yi, W., Gao, F., Sun, Y., & Zhang, X. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102848 · Cited by 5 · see citing works
Ouyang, X., Deng, W., Li, Y., Zou, Y. S., Yan, W., Yang, F., Zhu, J., & Tong, F. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120774 · Cited by 5 · see citing works
Azarfarin, M., Shahla, M. M., Mohaddes, G., & Dadkhah, M. (2025) · Acta Neuropsychiatrica · doi:10.1017/neu.2024.39 · Cited by 5 · see citing works
Systematic review of the impact of physical activity on depression and anxiety symptoms
Ioan, M. R., & Oravițan, M. (2022) · Journal of Physical Education and Human Movement · doi:10.24310/jpehmjpehmjpehm.v4i215703 · Cited by 5 · see citing works
Choi, N. G., Choi, B. Y., & Marti, C. N. (2024) · Gerontology and Geriatric Medicine · doi:10.1177/23337214241241397 · Cited by 5 · see citing works
Dong, Q., Li, S., Zhu, X., Lin, K., Li, Y., Wang, S., & Shi, Y. (2026) · BMC Gastroenterology · doi:10.1186/s12876-025-04590-8 · Cited by 4 · see citing works
The impact of physical activity on mental disorders
Jakubowska, K., Jerzak, A., Janocha, A., & Ziemba, P. (2024) · Quality in Sport · doi:10.12775/qs.2024.18.53286 · Cited by 4 · see citing works
Unlocking the Power of Physical Activity in Inflammatory Bowel Disease: A Comprehensive Review
Chen, J., & Sun, S. (2024) · Gastroenterology Research and Practice · doi:10.1155/grp/7138811 · Cited by 4 · see citing works
Ficarra, S., Kang, D., Wilson, R. L., Encabo, P. G., Christopher, C. N., Normann, A. J., López, P., Lakičević, N., & Dieli-Conwright, C. M. (2025) · Lung Cancer · doi:10.1016/j.lungcan.2025.108413 · Cited by 3 · see citing works
Thummasorn, S., Sa‐nguanmoo, P., Sirisatayawong, P., Ingding, A., Kumkun, C., Pittayaporn, N., Tupsai, P., Morthin, S., & Phithakleelanon, O. (2025) · PLoS ONE · doi:10.1371/journal.pone.0325516 · Cited by 3 · see citing works
Friedmann, E., Gee, N. R., Simonsick, E. M., Resnick, B. M., Gurlu, M., Adesanya, I., & Shim, S. (2025) · Geriatrics · doi:10.3390/geriatrics10060156 · Cited by 2 · see citing works
Liu, C., Zhai, F., Li, M., Wang, H., Zhang, J., Ji, Z., & Li, H. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1650334 · Cited by 2 · see citing works
Effects of Combined Music and Exercise Therapy on Depression: A Systematic Review and Meta-Analysis
Luo, X., Zhang, X., Vicario, C. M., Mei, Z., & Qi, F. (2026) · Journal of Integrative and Complementary Medicine · doi:10.1177/27683605261416759 · Cited by 2 · see citing works
Zhao, S., & Huang, H. (2026) · BMC Geriatrics · doi:10.1186/s12877-026-07517-4 · Cited by 2 · see citing works
Almasri, R. M. A., & Shanb, A. A. (2023) · Electronic Journal of General Medicine · doi:10.29333/ejgm/14018 · Cited by 2 · see citing works
Zheng, J., Zhang, X., Liu, S., Ye, F., Ji, S.-G., & Wen, X. (2023) · Medical Science Monitor · doi:10.12659/msm.943196 · Cited by 2 · see citing works
Aerobic training effect on mental health and biological indicators in Post-COVID-19 patients
Olivares, L. A. F., Villa-García, E. N., Sánchez-Márquez, Y., Salazar-Enríquez, V. M., Salais-Chaparro, A. D. J., & del Castillo, L. A. E. (2024) · Retos · doi:10.47197/retos.v52.101983 · Cited by 2 · see citing works
Mamun, G. M. S., Hassan, M. Z., Khatun, A., Kabir, M. F., Shaima, S. N., Afrin, S., & Seoty, N. R. (2022) · medRxiv · doi:10.1101/2022.10.23.22281426 · Cited by 2 · see citing works
Liang, Z., Li, C.-Y., Sui, S., He, Z., Ren, Y., Zhou, Z., & Kim, K. (2025) · Healthcare · doi:10.3390/healthcare13131545 · Cited by 1 · see citing works
Sewerbidges‐Williams, L. B., Santos, H. D., Oh, J., & Soliman, G. (2025) · Health Science Reports · doi:10.1002/hsr2.71284 · Cited by 1 · see citing works
Examining the relationship between fear of falling and depression in older adults in Turkey
Çankaya, M., & Takı, F. N. (2025) · BMC Psychology · doi:10.1186/s40359-025-03831-5 · Cited by 1 · see citing works
Munyangane, O. L., Lekgothoane, K., & Khumalo, K. (2025) · African Journal for Physical Activity and Health Sciences (AJPHES) · doi:10.37597/ajphes.2025.31.3.4 · Cited by 1 · see citing works
Lin, Z., Lin, F., & Su, M. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1726598 · Cited by 1 · see citing works
Lisano, J. K., Rosa, L., Giordano, G., Bryan, A. D., & Bidwell, L. (2026) · Clinical Therapeutics · doi:10.1016/j.clinthera.2026.02.007 · Cited by 1 · see citing works
The Role of Exercise in the Correction of Cognitive Impairment in Older Adults. Literature Review
Потехина, Н. Н., & Скугаревская, М. М. (2023) · Психиатрия психотерапия и клиническая психология · doi:10.34883/pi.2023.14.4.011 · Cited by 1 · see citing works
Du, X., & Kong, J. (2024) · International Journal of Mental Health Promotion · doi:10.32604/ijmhp.2024.049764 · Cited by 1 · see citing works
Bewegung und Sport in der Psychotherapie
Michalak, J., Wolf, S., Frei, A. K., & Heidenreich, T. (2025) · Die Psychotherapie · doi:10.1007/s00278-025-00776-3 · Cited by 1 · see citing works
Stroke: Current State of the Problem
Gusev, E. I., & Martynov, M. Y. (2025) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-025-01804-0 · Cited by 1 · see citing works
Influence of Continuous Nursing Intervention on Treatment Compliance of Patients with Depression
He, Y., He, J., & Hou, X. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/7080678 · Cited by 1 · see citing works
RetractedObata, A., Sano, Y., & Hirose, N. (2022) · IEEE-EMBS Conference on Biomedical Engineering and Sciences · doi:10.1109/iecbes54088.2022.10079645 · Cited by 1 · see citing works
Verdugo, S. A. A., Silva, S. P. G., Araya, A. R. M., Cabezas, G., Selaive, R. A. S., Saavedra, G. D. C., & Sánchez, C. E. Z. (2022) · Retos · doi:10.47197/retos.v47.94672
Guo, J., Huang, S., Chen, M., Xu, J., Lin, F., Li, H., Kang, D., & Wu, S. (2022) · Research Square · doi:10.21203/rs.3.rs-2320743/v1
Liao, T., Tang, Y., Yang, X., Gao, Y., Liu, Y., Pan, G., Zhu, P., Tao, F., & Shao, S. (2023) · Research Square · doi:10.21203/rs.3.rs-2994921/v1
Saigal, P., & Ali, N. (2023) · Evidence-Based Practice · doi:10.1097/ebp.0000000000001891
Exercício físico como modalidade alternativa de tratamento da depressão
Rodrigues, D. D. S., Tavares, E. S., Linhares, G. P. A., Cota, R. B., & Dantas, R. A. E. (2024) · Cuadernos de Educación y Desarrollo · doi:10.55905/cuadv16n2-ed.esp.350
Guardia, L. D., Salvetti, M., Palombi, T., Alivernini, F., Epifano, V., Mariani, C., Lucidi, F., Chirico, A., & Codella, R. (2024) · Research Square · doi:10.21203/rs.3.rs-3878614/v1
Implicações do exercício físico na condução terapêutica dos transtornos depressivos
de Almeida, R. B., Ferraz, M. A. M., Okata, K. M. S. D. O., Costa, F. M., Boianovsky, C. D., Bauer, I. O. B., Menezes, R. B. S., de Souza, I. B., & Nápoli, A. E. R. (2024) · Brazilian Journal of Health Review · doi:10.34119/bjhrv7n2-324
ESTUDO SOBRE A RELAÇÃO ENTRE RABDOMIÓLISE E ATIVIDADE FÍSICA
Bortoletto, G., Bachega, Y. C., Rabano, L. G. R., & da Rocha, B. A. (2023) · Revista Omnia Saúde · doi:10.29327/2272174.6.1-30
Depression in elderly individuals in physical exercise program
Dantas, K. B. A., Reis, F. P., Santos, M. A. A., Rocha, C. B. O., Chagas, C. C. C., Santos, J. M. D. O., da Costa, L. F. G. R., Menezes, M. L. D. A., Morais, R. P., & Dantas, E. H. M. (2024) · Cuerpo Cultura y Movimiento · doi:10.15332/2422474x.9910
Dai, Z.-Q., Gong, X., Zhang, R., Jin, M.-Q., Lu, W., Wen, W., Chen, J., Lu, F.-J., Yang, Y.-F., Wang, L., et al. (2024) · World Journal of Orthopedics · doi:10.5312/wjo.v15.i10.950
(2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23565-8.09996-8
da Silva, B. F. M., Silva, C. R., de Oliveira, D. V., Júnior, J. R. A. D. N., Salem, A. C. A., Corrêa, T. G. C., Mariotto, R. A., Dantas, A. C. A., Felipe, D. F., & Anversa, A. L. B. (2025) · Revista Psicologia e Saúde · doi:10.20435/pssa.v16i1.2467
Poveda-López, J. L., Jiménez‐Sánchez, C., Lafuente-Ureta, R., Marco-Gómez, B., Villagrasa-Cantín, A., Pérez-Mansilla, S., Guarch-Rubio, M., & Roy‐Delgado, J. F. (2025) · medRxiv · doi:10.1101/2025.05.25.25328327
Ju, Y., Liu, X., Zhao, L., Xie, X., Jin, H., Chi, J., Miao, S., & Li, Z. (2025) · BMC Geriatrics · doi:10.1186/s12877-025-06085-3
The Influence of Exercise on Pain Empathy
陈, 露. (2025) · Advances in Social Sciences · doi:10.12677/ass.2025.148713
Association between muscle quality index and depression in adults: A cross-sectional study
He, Y., shi, S., Liang, Z., & Wang, J. (2025) · Clinical Nutrition Open Science · doi:10.1016/j.nutos.2025.09.004
WITHDRAWN: Effects of Tai Chi on Reduction of Environmental Pollutants in Young Adults
Wang, J., Xu, T., Chen, L. Y., Wang, Y., Yu, Y. H., Wang, S., Gu, Y., Li, Y., Shen, N., Zhao, Y., et al. (2025) · Pharmacological Research - Modern Chinese Medicine · doi:10.1016/j.prmcm.2025.100720
RetractedActividad física y depresión en un centro integral del adulto mayor de Lima
Meléndez, M. Y. A., León, R. C., & Rivero-Álvarez, R. P. (2025) · Investigación e Innovación Revista Científica de Enfermería · doi:10.33326/27905543.2025.4.2445
Tassone, V. K., Lin, Q., Li, G. H., Rao, A., Duscio, V., Mathur, T., Uthayakumar, H., Sohail, S. Z., Kar, S., Quesnel, D. A., et al. (2026) · Psychotherapy and Psychosomatics · doi:10.1159/000550802
Lin, S., Chen, Z., & Zhang, W. (2026) · Journal of Aging and Physical Activity · doi:10.1123/japa.2024-0377
Sun, L., Shu-Sheng, S. H. I., & Fang, P. (2026) · Research Square · doi:10.21203/rs.3.rs-8489020/v1
Sun, Y., Zi, Z., Wang, S., Weng, M., Peng, J., Liu, L., Zhou, J., Wang, N., Liu, B., Liu, K., et al. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1721346
Physical activity and mental health
Czyż, P., & Nowobilski, R. (2026) · Psychiatria i Psychologia Kliniczna · doi:10.15557/pipk.2026.0012
Liang, H., & Wang, Z. (2026) · Research Square · doi:10.21203/rs.3.rs-10568975/v1
Kocamer, M. Y., & Biçki, D. (2026) · İzmir Katip Çelebi Üniversitesi Sağlık Bilimleri Fakültesi Dergisi · doi:10.61399/ikcusbfd.1836337
Fysisk trening som behandling av depresjon – Forskningsevidens og norske psykologers bidrag
Herrebrøden, H., Wara, A. T., & Skaftnes, K. (2026) · Tidsskrift for Norsk psykologforening · doi:10.52734/eprb7436
- Authors
- Hidalgo, J. L.-T., Sotos, J. R., & DEP-EXERCISE Group
- Venue
- The Annals of Family Medicine
- Publisher
- Annals of Family Medicine
- Published
- 2021-07
- Volume
- 19
- Issue
- 4
- Pages
- 302-309
- ISSN
- 1544-1709 (ISSN-L)
- 1544-1717
- PMC
- PMC8282290
- OpenAlex
- W3177800321
- Cited by
- 76
- References
- 43
- Citations by year
- 2026: 15 · 2025: 22 · 2024: 20 · 2023: 11 · 2022: 8
- FWCI
- 6.12
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- The Annals of Family Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- RUIdeRA - Institutional University Repository (University of Castilla-La Mancha) (submittedVersion, other-oa)
- Funders
- European Regional Development Fund
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- physical activity, depression, older adults, antidepressants, depressive symptoms, exercise therapy, primary care, adverse effects, treatment withdrawal, antidepressant efficacy
- MeSH terms
- Aged, Aged, 80 and over, Antidepressive Agents, Depression, Exercise Therapy, Female, Humans, Male, Primary Health Care, Exercise, Treatment Outcome, Intention to Treat Analysis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
