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Cited by 193Exercise and Physiological ResponsesStress Responses and CortisolAdrenal Hormones and Disorders

Acute and chronic effects of exercise on tissue sensitivity to glucocorticoids

Duclos, M., Gouarne, C., Bonnemaison, D.·2003·Journal of Applied Physiology
DOI 10.1152/japplphysiol.00108.2002
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Abstract

The aim of this study was to address the effect of endurance training on tissue sensitivity to glucocorticoids (GC) in both resting and exercising conditions. In vitro dexamethasone inhibition of LPS-induced interleukin-6 secretion in cultures of peripheral monocytes was compared in untrained subjects (UT) and in endurance-trained men (ET) at the end of a 2-h run and during exercise recovery. We demonstrated an in vitro plasticity of sensitivity of monocytes to GC in ET men, superimposed to changes in systemic cortisol concentrations (plasma and saliva). Compared with sedentary men, similar resting cortisol levels in ET men are associated with decreased sensitivity of monocytes to GC 8 and 24 h after the end of the last training session (P 0.05). This acute exercise-induced increase in tissue sensitivity to GC, which is synchronous with activation of the hypothalamo-pituitary adrenal axis, may act to shut off muscle inflammatory reaction and cytokine synthesis and then decrease exercise-induced muscle damage or inflammatory response. By contrast, the decreased sensitivity of monocytes to GC reported in ET men 24 h after the last bout of exercise may be related to the process of desensitization that may act to protect the body from prolonged, exercise-induced cortisol secretion. These acute and chronic effects of exercise on tissue sensitivity to GC demonstrate an adaptation of the hypothalamo-pituitary adrenal axis to repeated and prolonged exercise-induced increases in GC se…

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  • Physical activity may have physiological effects such as changes in endorphin and monoamine levels, or reduction in the levels of the stress hormone cortisol, which may improve mood.

    “Physical activity may have physiological effects such as changes in endorphin and monoamine levels, or reduction in the levels of the stress hormone cortisol (Duclos 2003) which all may improve mood.”

    From Exercise for depression (2009) · cites this paper as Duclos 2003

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Authors
Duclos, M., Gouarne, C., & Bonnemaison, D.
Affiliations
  • Inserm (FR)
  • Laboratoire Neurogénétique et Stress, INSERM U471, Institut François Magendie, UniversitéBordeaux II, 33077 Bordeaux Cedex; and
  • Université de Bordeaux (FR)
Venue
Journal of Applied Physiology
Publisher
American Physiological Society
Published
2003-03-01
Volume
94
Issue
3
Pages
869-875
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
DOI
10.1152/japplphysiol.00108.2002
OpenAlex
W2064716764
Cited by
193
References
32
Citations by year
2026: 9 · 2025: 7 · 2024: 5 · 2023: 10 · 2022: 10 · 2021: 7 · 2020: 14 · 2019: 13 · 2018: 4 · 2017: 6 · 2016: 11 · 2015: 5 · 2014: 6 · 2013: 9 · 2012: 16
FWCI
6.72
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
glucocorticoid sensitivity, endurance training, physical activity, monocytes, dexamethasone, interleukin-6, lipopolysaccharide, cortisol, hypothalamic-pituitary-adrenal axis, exercise-induced inflammation, post-exercise recovery
MeSH terms
Adult, Blood Glucose, Blood Volume, Dexamethasone, Glucocorticoids, Hormones, Humans, Lipopolysaccharides, Male, Monocytes, Physical Fitness, Rest, Saliva, Exercise, Interleukin-6, In Vitro Techniques

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