Correction: African Ancestry and Its Correlation to Type 2 Diabetes in African Americans: A Genetic Admixture Analysis in Three U.S. Population Cohorts
Open accessAbstract
The risk of type 2 diabetes is approximately 2-fold higher in African Americans than in European Americans even after adjusting for known environmental risk factors, including socioeconomic status (SES), suggesting that genetic factors may explain some of this population difference in disease risk.However, relatively few genetic studies have examined this hypothesis in a large sample of African Americans with and without diabetes.Therefore, we performed an admixture analysis using 2,189 ancestry-informative markers in 7,021 African Americans (2,373 with type 2 diabetes and 4,648 without) from the Atherosclerosis Risk in Communities Study, the Jackson Heart Study, and the Multiethnic Cohort to 1) determine the association of type 2 diabetes and its related quantitative traits with African ancestry controlling for measures of SES and 2) identify genetic loci for type 2 diabetes through a genome-wide admixture mapping scan.The median percentage of African ancestry of diabetic participants was slightly greater than that of non-diabetic participants (study-adjusted difference = 1.6%, P,0.001).The odds ratio for diabetes comparing participants in the highest vs. lowest tertile of African ancestry was 1.33 (95% confidence interval 1.13-1.55),after adjustment for age, sex, study, body mass index (BMI), and SES.Admixture scans identified two potential loci for diabetes at 12p13.31 (LOD = 4.0) and 13q14.3(Z score = 4.5, P = 6.6610 26 ).In conclusion, genetic ancestry has a significant association with type 2 diabetes above and beyond its association with nongenetic risk factors for type 2 diabetes in African Americans, but no single gene with a major effect is sufficient to explain a large portion of the observed population difference in risk of diabetes.There undoubtedly is a complex interplay among specific genetic loci and non-genetic factors, which may both be associated with overall admixture, leading to the observed ethnic differences in diabetes risk.
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Admixture studies generally find that admixture relates to the trait under investigation above and beyond covariates.
“These studies generally find that admixture relates to the trait under investigation above and beyond covariates.”
From Global Ancestry and Cognitive Ability (2019) · cites this paper as [37]
The Discussion reports that greater African ancestry was associated with type 2 diabetes and HbA1c even after adjustment for BMI and socioeconomic markers. This supports the cited study as an example, but the paper does not establish that admixture studies generally find such associations across traits. (LLM, conf=0.83)
Experimental — accuracy not yet measuredAfrican-Americans have around 20% European DNA.
“Generally, African-Americans have around 20% European DNA [37,[59][60][61][62].”
From Global Ancestry and Cognitive Ability (2019) · cites this paper as [37]
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- Authors
- Cheng, C.-Y., Reich, D., Haiman, C. A., Tandon, A., Patterson, N., Elizabeth, S., Akylbekova, E. L., Brancati, F. L., Coresh, J., Boerwinkle, E., Altshuler, D., Taylor, H. A., Henderson, B. E., Wilson, J. G., & Kao, W. H. L.
- Affiliations
- Johns Hopkins University (US)
- Broad Institute (US)
- University of Southern California (US)
- Jackson State University (US)
- The University of Texas Health Science Center at Houston (US)
- Tougaloo College (US)
- University of Mississippi Medical Center (US)
- Corresponding author
- Kao, W. H. Linda
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-09-20
- Volume
- 7
- Issue
- 9
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3466099
- OpenAlex
- W4240454055
- Cited by
- 2
- References
- 52
- Citations by year
- 2019: 1 · 2018: 1
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Johns Hopkins University (N01-HG-65403)
- Ministerio de Economía y Competitividad (CA63464, CA54281)
- National Institutes of Health (N01-HC55020, N01-HC-55021, N01‐HG‐65403, N01-HC-95172, P60-DK079637, N01-HC-55019, N01-HC-55022, N01-HC55016, N01-HC-95170, N01-HC55018, CA54281, CA63464, N01-HC-55015, N01-HC-95171)
- National Heart, Lung, and Blood Institute (N01-HV-48195, N01-HC55022, N01-HC-55018, N01 HC 55020, N01 HC 55019, N01HC95172, N01-HC55016, N01 HC 95170, N01‐HC‐55015, N01-HC55021, N01 HC-95171)
- National Cancer Institute (CA63464, CA 54281)
- National Institute of Diabetes and Digestive and Kidney Diseases (P60 DK-079637, N01-HC-55016, N01-HC-55018, N01-HC-55021, N01-HC-55020, N01-HC-55015, N01-HC-55019, N01-HC-55022)
- National Center on Minority Health and Health Disparities
- National Institute on Minority Health and Health Disparities
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Race, Genetics, and Society
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Keywords
- type 2 diabetes, African ancestry, African Americans, genetic admixture, admixture mapping, ancestry informative markers, socioeconomic status, ethnic differences in diabetes risk, quantitative traits
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