The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Calcium Dynamics of Cortical Astrocytic Networks In Vivo
Open accessAbstract
Large and long-lasting cytosolic calcium surges in astrocytes have been described in cultured cells and acute slice preparations. The mechanisms that give rise to these calcium events have been extensively studied in vitro. However, their existence and functions in the intact brain are unknown. We have topically applied Fluo-4 AM on the cerebral cortex of anesthetized rats, and imaged cytosolic calcium fluctuation in astrocyte populations of superficial cortical layers in vivo, using two-photon laser scanning microscopy. Spontaneous [Ca(2+)](i) events in individual astrocytes were similar to those observed in vitro. Coordination of [Ca(2+)](i) events among astrocytes was indicated by the broad cross-correlograms. Increased neuronal discharge was associated with increased astrocytic [Ca(2+)](i) activity in individual cells and a robust coordination of [Ca(2+)](i) signals in neighboring astrocytes. These findings indicate potential neuron-glia communication in the intact brain.
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Glutamate Induces Calcium Waves in Cultured Astrocytes: Long-Range Glial Signaling
Cornell-Bell, A. H., Finkbeiner, S. M., Cooper, M. S., & Smith, S. J. (1990) · Science · doi:10.1126/science.1967852 · Cited by 1,846
Signaling at the Gliovascular Interface
Simard, M., Arcuino, G., Takano, T., Liu, Q. S., & Nedergaard, M. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-27-09254.2003 · Cited by 586
Ren, J. Q., Aika, Y., Heizmann, C. W., & Kosaka, T. (1992) · Experimental Brain Research · doi:10.1007/bf00230378 · Cited by 148
Spike-and-wave epilepsy in rats: sex differences and inheritance of physiological traits
Jando´, G., Carpi, D., Kandel, A., Urioste, R., Horvath, Z., Pierre, E., Vadi, D., Vadasz, C., & Buzsa´ki, G. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00329-4 · Cited by 72
Cited by
Astrocytes, from brain glue to communication elements: the revolution continues
Volterra, A., & Meldolesi, J. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1722 · Cited by 1,770
Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678
Principles of two-photon excitation microscopy and its applications to neuroscience
Svoboda, K., & Yasuda, R. (2006) · Neuron · doi:10.1016/j.neuron.2006.05.019 · Cited by 1,027
Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo
Nimmerjahn, A., Kirchhoff, F., Kerr, J. N. D., & Helmchen, F. (2004) · Nature Methods · doi:10.1038/nmeth706 · Cited by 784
Synchronous Hyperactivity and Intercellular Calcium Waves in Astrocytes in Alzheimer Mice
Kuchibhotla, K. V., Lattarulo, C. R., Hyman, B. T., & Bacskai, B. J. (2009) · Science · doi:10.1126/science.1169096 · Cited by 729
Metadata
- Authors
- Hirase, H., Qian, L., Barthó, P., & Buzsáki, G.
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2004-04-13
- Volume
- 2
- Issue
- 4
- Pages
- e96
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- OpenAlex
- W2167670991
- Cited by
- 398
- References
- 4
- FWCI
- 6.12
- Type
- journal article
- Language
- en
- Open access
- gold
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