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Cited by 398

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

Calcium Dynamics of Cortical Astrocytic Networks In Vivo

Open access
Hirase, Hajime, Qian, Lifen, Barthó, Peter, Buzsáki, György·2004·PLoS Biology
DOI 10.1371/journal.pbio.0020096
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Abstract

Large and long-lasting cytosolic calcium surges in astrocytes have been described in cultured cells and acute slice preparations. The mechanisms that give rise to these calcium events have been extensively studied in vitro. However, their existence and functions in the intact brain are unknown. We have topically applied Fluo-4 AM on the cerebral cortex of anesthetized rats, and imaged cytosolic calcium fluctuation in astrocyte populations of superficial cortical layers in vivo, using two-photon laser scanning microscopy. Spontaneous [Ca(2+)](i) events in individual astrocytes were similar to those observed in vitro. Coordination of [Ca(2+)](i) events among astrocytes was indicated by the broad cross-correlograms. Increased neuronal discharge was associated with increased astrocytic [Ca(2+)](i) activity in individual cells and a robust coordination of [Ca(2+)](i) signals in neighboring astrocytes. These findings indicate potential neuron-glia communication in the intact brain.

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Crossref · 10.1371/journal.pbio.0020096

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Metadata

Authors
Hirase, H., Qian, L., Barthó, P., & Buzsáki, G.
Venue
PLoS Biology
Publisher
Public Library of Science (PLoS)
Published
2004-04-13
Volume
2
Issue
4
Pages
e96
ISSN
  • 1544-9173 (ISSN-L)
  • 1545-7885
DOI
10.1371/journal.pbio.0020096
OpenAlex
W2167670991
Cited by
398
References
36
FWCI
6.12
Type
journal article
Language
en
Open access
gold

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