The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Gene Expression Analysis of Zebrafish Heart Regeneration
Open accessAbstract
Mammalian hearts cannot regenerate. In contrast, zebrafish hearts regenerate even when up to 20% of the ventricle is amputated. The mechanism of zebrafish heart regeneration is not understood. To systematically characterize this process at the molecular level, we generated transcriptional profiles of zebrafish cardiac regeneration by microarray analyses. Distinct gene clusters were identified based on temporal expression patterns. Genes coding for wound response/inflammatory factors, secreted molecules, and matrix metalloproteinases are expressed in regenerating heart in sequential patterns. Comparisons of gene expression profiles between heart and fin regeneration revealed a set of regeneration core molecules as well as tissue-specific factors. The expression patterns of several secreted molecules around the wound suggest that they play important roles in heart regeneration. We found that both platelet-derived growth factor-a and -b (pdgf-a and pdgf-b) are upregulated in regenerating zebrafish hearts. PDGF-B homodimers induce DNA synthesis in adult zebrafish cardiomyocytes. In addition, we demonstrate that a chemical inhibitor of PDGF receptor decreases DNA synthesis of cardiomyocytes both in vitro and in vivo during regeneration. Our data indicate that zebrafish heart regeneration is associated with sequentially upregulated wound healing genes and growth factors and suggest that PDGF signaling is required.
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Cites
Cluster analysis and display of genome-wide expression patterns
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Heart Regeneration in Zebrafish
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Self-citationEvidence That Human Cardiac Myocytes Divide after Myocardial Infarction
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The PDGF family: four gene products form five dimeric isoforms
Fredriksson, L., Li, H., & Eriksson, U. (2004) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2004.03.007 · Cited by 838
Unchain my heart: the scientific foundations of cardiac repair
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p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes
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Self-citationProgranulin is a mediator of the wound response
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Cited by
Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation
Jopling, C., Sleep, E., Raya, M., Martí, M., Raya, A., & Belmonte, J. C. I. (2010) · Nature · doi:10.1038/nature08899 · Cited by 1,333
Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration
Jopling, C., Boue, S., & Belmonte, J. C. I. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3043 · Cited by 730
The zebrafish as a model for complex tissue regeneration
Gemberling, M., Bailey, T. J., Hyde, D. R., & Poss, K. D. (2013) · Trends in Genetics · doi:10.1016/j.tig.2013.07.003 · Cited by 566
Functional Recovery of a Human Neonatal Heart After Severe Myocardial Infarction
Haubner, B. J., Schneider, J., Schweigmann, U., Schuetz, T., Dichtl, W., Velik-Salchner, C., Stein, J.-I., & Penninger, J. M. (2016) · Circulation Research · doi:10.1161/circresaha.115.307017 · Cited by 346
Mechanisms of Cardiac Regeneration
Uygur, A., & Lee, R. T. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.01.018 · Cited by 286
Metadata
- Authors
- Lien, C.-L., Schebesta, M., Makino, S., Weber, G. J., & Keating, M. T.
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2006-08-01
- Volume
- 4
- Issue
- 8
- Pages
- e260
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- OpenAlex
- W1965128951
- Cited by
- 272
- References
- 38
- FWCI
- 5.40
- Type
- journal article
- Language
- en
- Open access
- gold
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- Lien, C.-L., Schebesta, M., Makino, S., Weber, G. J., & Keating, M. T. (2006). Gene Expression Analysis of Zebrafish Heart Regeneration. PLoS Biology. https://doi.org/10.1371/journal.pbio.0040260
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