The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Functional Recovery of a Human Neonatal Heart After Severe Myocardial Infarction
Abstract
Rationale : Cardiac remodeling and subsequent heart failure remain critical issues after myocardial infarction despite improved treatment and reperfusion strategies. Recently, cardiac regeneration has been demonstrated in fish and newborn mice after apex resection or cardiac infarctions. Two key issues remain to translate findings in model organisms to future therapies in humans: what is the mechanism and can cardiac regeneration indeed occur in newborn humans? Objective : To assess whether human neonatal hearts can functionally recover after myocardial infarction. Methods and Results : Here, we report the case of a newborn child having a severe myocardial infarction due to coronary artery occlusion. The child developed massive cardiac damage as defined by serum markers for cardiomyocyte cell death, electrocardiograms, echocardiography, and cardiac angiography. Remarkably, within weeks after the initial ischemic insult, we observed functional cardiac recovery, which translated into long-term normal heart function. Conclusions : These data indicate that, similar to neonatal rodents, newborn humans might have the intrinsic capacity to repair myocardial damage and completely recover cardiac function.
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1 retracted
Cardiomyogenesis in the Adult Human Heart
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Self-citationEvidence for Cardiomyocyte Renewal in Humans
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Cardioids reveal self-organizing principles of human cardiogenesis
Hofbauer, P., Jahnel, S. M., Papai, N., Giesshammer, M., Deyett, A., Schmidt, C., Penc, M., Tavernini, K., Grdseloff, N., Meledeth, C., et al. (2021) · Cell · doi:10.1016/j.cell.2021.04.034 · Cited by 588
Cahill, T. J., Choudhury, R. P., & Riley, P. R. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.106 · Cited by 312
How is cardiac troponin released from injured myocardium?
Mair, J., Lindahl, B., Hammarsten, O., Müller, C., Giannitsis, E., Huber, K., Möckel, M., Plebani, M., Thygesen, K., & Jaffe, A. S. (2018) · European Heart Journal: Acute Cardiovascular Care · doi:10.1177/2048872617748553 · Cited by 267
Myeloid cell contributions to cardiovascular health and disease
Nahrendorf, M. (2018) · Nature Medicine · doi:10.1038/s41591-018-0064-0 · Cited by 258
Comparative regenerative mechanisms across different mammalian tissues
Iismaa, S. E., Kaidonis, X., Nicks, A. M., Bogush, N., Kikuchi, K., Naqvi, N., Harvey, R. P., Husain, A., & Graham, R. M. (2018) · npj Regenerative Medicine · doi:10.1038/s41536-018-0044-5 · Cited by 253
Metadata
- Authors
- Haubner, B. J., Schneider, J., Schweigmann, U., Schuetz, T., Dichtl, W., Velik-Salchner, C., Stein, J.-I., & Penninger, J. M.
- Venue
- Circulation Research
- Published
- 2016-01-22
- Volume
- 118
- Issue
- 2
- Pages
- 216-221
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2191859395
- Cited by
- 346
- References
- 28
- FWCI
- 8.36
- Type
- journal article
- Language
- en
- Open access
- closed
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- Haubner, B. J., Schneider, J., Schweigmann, U., Schuetz, T., Dichtl, W., Velik-Salchner, C., Stein, J.-I., & Penninger, J. M. (2016). Functional Recovery of a Human Neonatal Heart After Severe Myocardial Infarction. Circulation Research. https://doi.org/10.1161/circresaha.115.307017
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
