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Cited by 1,007

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

Autophagy Counterbalances Endoplasmic Reticulum Expansion during the Unfolded Protein Response

Open access
Bernales, Sebastián, McDonald, Kent L, Walter, Peter·2006·PLoS Biology
DOI 10.1371/journal.pbio.0040423
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Abstract

The protein folding capacity of the endoplasmic reticulum (ER) is regulated by the unfolded protein response (UPR). The UPR senses unfolded proteins in the ER lumen and transmits that information to the cell nucleus, where it drives a transcriptional program that is tailored to re-establish homeostasis. Using thin section electron microscopy, we found that yeast cells expand their ER volume at least 5-fold under UPR-inducing conditions. Surprisingly, we discovered that ER proliferation is accompanied by the formation of autophagosome-like structures that are densely and selectively packed with membrane stacks derived from the UPR-expanded ER. In analogy to pexophagy and mitophagy, which are autophagic processes that selectively sequester and degrade peroxisomes and mitochondria, the ER-specific autophagic process described utilizes several autophagy genes: they are induced by the UPR and are essential for the survival of cells subjected to severe ER stress. Intriguingly, cell survival does not require vacuolar proteases, indicating that ER sequestration into autophagosome-like structures, rather than their degradation, is the important step. Selective ER sequestration may help cells to maintain a new steady-state level of ER abundance even in the face of continuously accumulating unfolded proteins.

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Show all 12 references

Research works printed but not linked: 82

  1. Wickner, 2005, Science, 310, 1452
  2. Ellgaard, 2003, Nat Rev Mol Cell Biol, 4, 181
  3. McCracken, 2005, Curr Top Microbiol Immunol, 300, 17
  4. Ron, 2002, J Clin Invest, 110, 1383
  5. van Anken, 2005, Crit Rev Biochem Mol Biol, 40, 191
  6. Bernales, 2006, Annu Rev Cell Dev Biol, 22, 487
  7. Cox, 1993, Cell, 73, 1197
  8. Mori, 1993, Cell, 74, 743
  9. Credle, 2005, Proc Natl Acad Sci U S A, 102, 18773
  10. Shamu, 1996, EMBO J, 15, 3028
  11. Sidrauski, 1997, Cell, 90, 1031
  12. Kawahara, 1997, Mol Biol Cell, 8, 1845
  13. Cox, 1996, Cell, 87, 391
  14. Mori, 1996, Genes Cells, 1, 803
  15. Shen, 2001, Cell, 107, 893
  16. Yoshida, 2001, Cell, 107, 881
  17. Calfon, 2002, Nature, 415, 92
  18. Travers, 2000, Cell, 101, 249
  19. Ye, 2000, Mol Cell, 6, 1355
  20. Yoshida, 1998, J Biol Chem, 273, 33741
  21. Li, 2000, Mol Cell Biol, 20, 5096
  22. Kokame, 2001, J Biol Chem, 276, 9199
  23. Okada, 2002, Biochem J, 366, 585
  24. Leber, 2004, PLoS Biol, 2, 10.1371/journal.pbio.0020235 · DOI
  25. Meusser, 2005, Nat Cell Biol, 7, 766
  26. Romisch, 2005, Annu Rev Cell Dev Biol, 21, 435
  27. Yorimitsu, 2005, Cell Death Differ, 12, 1542
  28. Tsukada, 1993, FEBS Lett, 333, 169
  29. Thumm, 1994, FEBS Lett, 349, 275
  30. Harding, 1995, J Cell Biol, 131, 591
  31. Yuan, 1997, J Cell Sci, 110, 1935
  32. Takeshige, 1992, J Cell Biol, 119, 301
  33. Leao-Helder, 2004, FEBS Lett, 577, 491
  34. Hamasaki, 2005, Traffic, 6, 56
  35. Cuervo, 2004, Trends Cell Biol, 14, 70
  36. Hamasaki, 2003, Cell Struct Funct, 28, 49
  37. Ishihara, 2001, Mol Biol Cell, 12, 3690
  38. Reggiori, 2004, Mol Biol Cell, 15, 2189
  39. Dunn, 2005, Autophagy, 1, 75
  40. Kundu, 2005, Cell Death Differ, 12, 1484
  41. Harding, 1996, J Biol Chem, 271, 17621
  42. Scott, 1996, Proc Natl Acad Sci U S A, 93, 12304
  43. Baba, 1997, J Cell Biol, 139, 1687
  44. Scott, 1997, J Cell Biol, 138, 37
  45. McDonald, 1999, Methods Mol Biol, 117, 77
  46. Baba, 1995, Cell Struct Funct, 20, 465
  47. Baba, 1994, J Cell Biol, 124, 903
  48. Walther, 2002, J Microsc, 208, 3
  49. Shaner, 2004, Nat Biotechnol, 22, 1567
  50. Niwa, 2005, Genome Biol, 6, R3
  51. Papa, 2003, Science, 302, 1533
  52. Huang, 2000, J Biol Chem, 275, 5845
  53. Kirisako, 1999, J Cell Biol, 147, 435
  54. Ichimura, 2000, Nature, 408, 488
  55. Kirisako, 2000, J Cell Biol, 151, 263
  56. Reggiori, 2004, Dev Cell, 6, 79
  57. Suzuki, 2002, Dev Cell, 3, 815
  58. Suzuki, 2001, EMBO J, 20, 5971
  59. Kim, 2001, J Cell Biol, 152, 51
  60. Shintani, 2004, J Biol Chem, 279, 29889
  61. Schroder, 2000, Genes Dev, 14, 2962
  62. Suzuki, 2004, Yeast, 21, 1057
  63. Kamada, 2000, J Cell Biol, 150, 1507
  64. Lang, 2000, J Bacteriol, 182, 2125
  65. Mizushima, 1999, EMBO J, 18, 3888
  66. Yorimitsu, 2005, Mol Biol Cell, 16, 1593
  67. Shaffer, 2004, Immunity, 21, 81
  68. Sriburi, 2004, J Cell Biol, 167, 35
  69. Kruse, 2006, Mol Biol Cell, 17, 203
  70. Feldman, 1980, J Histochem Cytochem, 28, 997
  71. Chin, 1982, Proc Natl Acad Sci U S A, 79, 1185
  72. Orci, 1984, Cell, 36, 835
  73. Farre, 2004, Trends Cell Biol, 14, 515
  74. Mijaljica, 2007, Autophagy, 3
  75. Bellu, 2003, Microsc Res Tech, 61, 161
  76. Ng, 2000, J Cell Biol, 150, 77
  77. Juhasz, 2006, PLoS Biol, 4, 10.1371/journal.pbio.0040036 · DOI
  78. Teichert, 1989, J Biol Chem, 264, 16037
  79. Yorimitsu, 2006, J Biol Chem, 281, 30299
  80. Ogata, 2006, Mol Cell Biol
  81. Longtine, 1998, Yeast, 14, 953
  82. Heiman, 2000, J Cell Biol, 151, 719

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Metadata

Authors
Bernales, S., McDonald, K. L., & Walter, P.
Venue
PLoS Biology
Publisher
Public Library of Science (PLoS)
Published
2006-11-28
Volume
4
Issue
12
Pages
e423
ISSN
  • 1544-9173 (ISSN-L)
  • 1545-7885
DOI
10.1371/journal.pbio.0040423
OpenAlex
W2009741382
Cited by
1,007
References
12
FWCI
27.89
Type
journal article
Language
en
Open access
gold
Licence
creativecommons.org/licenses/by/4.0/ (unspecified)

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CoChat. (2026). Citation check: Autophagy Counterbalances Endoplasmic Reticulum Expansion during the Unfolded Protein Response. https://app.cochat.ai/papers/10.1371/journal.pbio.0040423
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Bernales, S., McDonald, K. L., & Walter, P. (2006). Autophagy Counterbalances Endoplasmic Reticulum Expansion during the Unfolded Protein Response. PLoS Biology. https://doi.org/10.1371/journal.pbio.0040423

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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