The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Open Syntaxin Docks Synaptic Vesicles
Open accessAbstract
Synaptic vesicles dock to the plasma membrane at synapses to facilitate rapid exocytosis. Docking was originally proposed to require the soluble N-ethylmaleimide-sensitive fusion attachment protein receptor (SNARE) proteins; however, perturbation studies suggested that docking was independent of the SNARE proteins. We now find that the SNARE protein syntaxin is required for docking of all vesicles at synapses in the nematode Caenorhabditis elegans. The active zone protein UNC-13, which interacts with syntaxin, is also required for docking in the active zone. The docking defects in unc-13 mutants can be fully rescued by overexpressing a constitutively open form of syntaxin, but not by wild-type syntaxin. These experiments support a model for docking in which UNC-13 converts syntaxin from the closed to the open state, and open syntaxin acts directly in docking vesicles to the plasma membrane. These data provide a molecular basis for synaptic vesicle docking.
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Citations
Cites
The structure of the nervous system of the nematode Caenorhabditis elegans
White, J. G., Southgate, E., Thomson, J. N., & Brenner, S. (1986) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1986.0056 · Cited by 5,589 · cited 1×
“elegans [94]; there are four acetylcholine commissures (green) and 16 GABA commissures (gray).”
Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution
Sutton, R. B., Fasshauer, D., Jahn, R., & Brunger, A. T. (1998) · Nature · doi:10.1038/26412 · Cited by 2,417 · cited 1×
“]. For synaptic vesicle fusion, the vesicular SNARE protein synaptobrevin (also called vesicle-associated membrane protein or VAMP) interacts with the plasma membrane SNARE proteins syntaxin and SNAP-25 to form a four-helix bundle [”
Quantitative ultrastructural analysis of hippocampal excitatory synapses
Schikorski, T., & Stevens, C. F. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-15-05858.1997 · Cited by 997
The structure of the ventral nerve cord of Caenorhabditis elegans
White, J. G., Southgate, E., Thomson, J. N., & Brenner, S. (1976) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1976.0086 · Cited by 616
Morphological correlates of functionally defined synaptic vesicle populations
Schikorski, T., & Stevens, C. F. (2001) · Nature Neuroscience · doi:10.1038/86042 · Cited by 516
Differential Control of the Releasable Vesicle Pools by SNAP-25 Splice Variants and SNAP-23
Sørensen, J. B., Nagy, G., Varoqueaux, F., Nehring, R. B., Brose, N., Wilson, M. C., & Neher, E. (2003) · Cell · doi:10.1016/s0092-8674(03)00477-x · Cited by 364
Ectopic Release of Synaptic Vesicles
Matsui, K., & Jahr, C. E. (2003) · Neuron · doi:10.1016/s0896-6273(03)00788-8 · Cited by 155
Fujiwara, T., Mishima, T., Kofuji, T., Chiba, T., Tanaka, K., Yamamoto, A., & Akagawa, K. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0289-06.2006 · Cited by 125
Cited by
Single-copy insertion of transgenes in Caenorhabditis elegans
Frøkjær-Jensen, C., Wayne Davis, M., Hopkins, C. E., Newman, B. J., Thummel, J. M., Olesen, S.-P., Grunnet, M., & Jorgensen, E. M. (2008) · Nature Genetics · doi:10.1038/ng.248 · Cited by 1,163
Self-citationRizo, J., & Rosenmund, C. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1450 · Cited by 538
The Morphological and Molecular Nature of Synaptic Vesicle Priming at Presynaptic Active Zones
Imig, C., Min, S.-W., Krinner, S., Arancillo, M., Rosenmund, C., Südhof, T. C., Rhee, J., Brose, N., & Cooper, B. H. (2014) · Neuron · doi:10.1016/j.neuron.2014.10.009 · Cited by 389
The Membrane Fusion Enigma: SNAREs, Sec1/Munc18 Proteins, and Their Accomplices—Guilty as Charged?
Rizo, J., & Südhof, T. C. (2012) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101011-155818 · Cited by 386
The Synaptic Vesicle Release Machinery
Rizo, J., & Xu, J. (2015) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-060414-034057 · Cited by 339
Metadata
- Authors
- Hammarlund, M., Palfreyman, M. T., Watanabe, S., Olsen, S., & Jorgensen, E. M.
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2007-07-17
- Volume
- 5
- Issue
- 8
- Pages
- e198
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- OpenAlex
- W2122310374
- Cited by
- 201
- References
- 8
- FWCI
- 6.57
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
