The DOI matches its Crossref record; 78 of the 79 references it cites were found in a registry or an index.
Microglial Interactions with Synapses Are Modulated by Visual Experience
Open accessAbstract
Microglia are the immune cells of the brain. In the absence of pathological insult, their highly motile processes continually survey the brain parenchyma and transiently contact synaptic elements. Aside from monitoring, their physiological roles at synapses are not known. To gain insight into possible roles of microglia in the modification of synaptic structures, we used immunocytochemical electron microscopy, serial section electron microscopy with three-dimensional reconstructions, and two-photon in vivo imaging to characterize microglial interactions with synapses during normal and altered sensory experience, in the visual cortex of juvenile mice. During normal visual experience, most microglial processes displayed direct apposition with multiple synapse-associated elements, including synaptic clefts. Microglial processes were also distinctively surrounded by pockets of extracellular space. In terms of dynamics, microglial processes localized to the vicinity of small and transiently growing dendritic spines, which were typically lost over 2 d. When experience was manipulated through light deprivation and reexposure, microglial processes changed their morphology, showed altered distributions of extracellular space, displayed phagocytic structures, apposed synaptic clefts more frequently, and enveloped synapse-associated elements more extensively. While light deprivation induced microglia to become less motile and changed their preference of localization to the vicinity of a subset of larger dendritic spines that persistently shrank, light reexposure reversed these behaviors. Taken together, these findings reveal different modalities of microglial interactions with synapses that are subtly altered by sensory experience. These findings suggest that microglia may actively contribute to the experience-dependent modification or elimination of a specific subset of synapses in the healthy brain.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Microglia have recently been implicated as active participants in brain plasticity per se (42–45).”
From Prolonged Period of Cortical Plasticity upon Redox Dysregulation in Fast-Spiking Interneurons (2015) · cites this paper as [42]
In the citing paper
“microglia participate in experience-dependent remodeling of neural circuits in the normal mature brain by removing extraneous synaptic elements [6, 74–77]”
From Microglial dysfunction in brain aging and Alzheimer's disease (2014) · cites this paper as [74]
In the citing paper
“Microglia also closely monitor neural activity and regulate synaptic plasticity.”
From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Tremblay et al., 2010
In the citing paper
“Microglia dynamically interact with neuronal circuits, making direct contacts with synaptic elements1819 in a way that is modulated by experience-dependent changes in neuronal activity19.”
From Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex (2016) · cites this paper as [19]
In the citing paper
“The motility of microglial processes and spine contact are actively regulated by sensory experience and are involved in spine elimination (Tremblay et al., 2010).”
From Spatiotemporal dynamics of dendritic spines in the living brain (2014) · cites this paper as Tremblay et al., 2010
In the citing paper
“Another type of glial cells, microglia, have also been found to be in close contact with dendritic spines.”
From Spatiotemporal dynamics of dendritic spines in the living brain (2014) · cites this paper as Tremblay et al., 2010
In the citing paper
“The motility of microglial processes and spine contact are actively regulated by sensory experience and are involved in spine elimination (Tremblay et al., 2010).”
From Spatiotemporal dynamics of dendritic spines in the living brain (2014) · cites this paper as Tremblay et al., 2010
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The mouse brain in stereotaxic coordinates
Konsman, J. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(03)00088-x · Cited by 16,796
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827
ATP mediates rapid microglial response to local brain injury in vivo
Davalos, D., Grutzendler, J., Yang, G., Kim, J. V., Zuo, Y., Jung, S., Littman, D. R., Dustin, M. L., & Gan, W.-B. (2005) · Nature Neuroscience · doi:10.1038/nn1472 · Cited by 3,913
Microglia: Active sensor and versatile effector cells in the normal and pathologic brain
Hanisch, U.-K., & Kettenmann, H. (2007) · Nature Neuroscience · doi:10.1038/nn1997 · Cited by 3,676
The Classical Complement Cascade Mediates CNS Synapse Elimination
Stevens, B., Allen, N. J., Vazquez, L. E., Howell, G. R., Christopherson, K. S., Nouri, N., Micheva, K. D., Mehalow, A. K., Huberman, A. D., Stafford, B., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.036 · Cited by 3,313
mouse brain in stereotaxic coordinates
Franklin, K. B. J., & Paxinos, G. (1997) · Cited by 3,258
Imaging Neuronal Subsets in Transgenic Mice Expressing Multiple Spectral Variants of GFP
Feng, G., Mellor, R. H., Bernstein, M., Keller-Peck, C., Nguyen, Q. T., Wallace, M., Nerbonne, J. M., Lichtman, J. W., & Sanes, J. R. (2000) · Neuron · doi:10.1016/s0896-6273(00)00084-2 · Cited by 3,042
Jung, S., Aliberti, J., Graemmel, P., Sunshine, M. J., Kreutzberg, G. W., Sher, A., & Littman, D. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.11.4106-4114.2000 · Cited by 2,632
Structural basis of long-term potentiation in single dendritic spines
Matsuzaki, M., Honkura, N., Ellis-Davies, G. C. R., & Kasai, H. (2004) · Nature · doi:10.1038/nature02617 · Cited by 2,483
Flagged first, then by citations
1 of the 79 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 801–900 of 1,003
Hristovska, I., Verdonk, F., Comte, J., Tsai, E. S., Desestret, V., Honnorat, J., Chrétien, F., & Pascual, O. (2020) · PLoS ONE · doi:10.1371/journal.pone.0236594 · Cited by 26
Impact of maternal immune activation on dendritic spine development
Pękała, M., Doliwa, M., & Kalita, K. B. (2020) · Developmental Neurobiology · doi:10.1002/dneu.22804 · Cited by 27
Fujita, Y., & Yamashita, T. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03758-1 · Cited by 30
In vivo mechanisms of cortical network dysfunction induced by systemic inflammation
Odoj, K., Brawek, B., Asavapanumas, N., Mojtahedi, N., Heneka, M. T., & Garaschuk, O. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.05.021 · Cited by 26
Paulo, D. C., Bento‐Torres, J., Filho, C. S., de Oliveira, T. C. G., de Sousa, A. A., dos Reis, R. R., dos Santos, Z. A., de Lima, C. M., Augusto‐Oliveira, M., Said, N. M., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.683026 · Cited by 28
VanderZwaag, J., Halvorson, T., Dolhan, K., Šimončičová, E., Ben‐Azu, B., & Tremblay, M. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03772-0 · Cited by 28
Self-citationZaccard, C. R., Gippo, I. R., Song, A., Geula, C., & Penzes, P. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1059730 · Cited by 27
Deivasigamani, S., Miteva, M. T., Natale, S., Gutierrez‐Barragan, D., Basilico, B., Angelantonio, S. D., Weinhard, L., Molotkov, D., Deb, S., Pape, C., et al. (2023) · Cerebral Cortex · doi:10.1093/cercor/bhad313 · Cited by 28
de Sousa, A. A., dos Reis, R. R., de Lima, C. M., Augusto‐Oliveira, M., Fernandes, T. N., Gomes, G. F., Diniz, D. G., Magalhães, N. G. D. M., Diniz, C. G., Sosthenes, M. C. K., et al. (2015) · European Journal of Neuroscience · doi:10.1111/ejn.12951 · Cited by 28
Karrer, M., Lopez, M., Meier, D. T., Mikhail, C., Ogunshola, O. O., Müller, A. F., Strauss, L., Tafti, M., & Fontana, A. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.11.008 · Cited by 26
Augusto‐Oliveira, M., Arrifano, G. D. P., Leal-Nazaré, C. G., Chaves-Filho, A. J. M., Santos-Sacramento, L., Lopes-Araújo, A., Tremblay, M., & Lopez, M. E. C. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106091 · Cited by 28
Self-citationRathod, S., Agrawal, Y. O., Nakhate, K. T., Meeran, M. F. N., Ojha, S. K., & Goyal, S. N. (2023) · Biomedicines · doi:10.3390/biomedicines11102642 · Cited by 25
Purine Signaling and Microglial Wrapping
Castellano, B., Bosch-Queralt, M., Almolda, B., Villacampa, N., & González, B. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-40764-7_7 · Cited by 25
Wong, E. L., Lutz, N. M., Hogan, V. A., Lamantia, C. E., McMurray, H. R., Myers, J. R., Ashton, J. M., & Majewska, A. K. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.09.003 · Cited by 27
Self-citationThe Role of Microglia in Neurodevelopmental Disorders and their Therapeutics
Coomey, R., Stowell, R. D., Majewska, A. K., & Tropea, D. (2020) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026620666200221172619 · Cited by 26
Self-citationMatovic, S., Ichiyama, A., Igarashi, H., Salter, E. W., Sunstrum, J. K., Wang, X. F., Henry, M. S., Kuebler, E. S., Vernoux, N., Martínez-Trujillo, J., et al. (2020) · The Journal of Physiology · doi:10.1113/jp279666 · Cited by 25
Self-citationDarwish, R., Alcibahy, Y., Bucheeri, S., Albishtawi, A., Tama, M., Shetty, J. K., & Butler, A. E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252313169 · Cited by 25
Infections in the Developing Brain: The Role of the Neuro-Immune Axis
Kim, J., Erice, C., Rohlwink, U. K., & Tucker, E. W. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.805786 · Cited by 28
The Properties and Functions of Glial Cell Types of the Hypothalamic Median Eminence
Clayton, R. W., Lovell-Badge, R. H., & Galichet, C. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.953995 · Cited by 28
Role of Microglia in Psychostimulant Addiction
da Silva, M. C. M., Iglesias, L. P., Candelario‐Jalil, E., Khoshbouei, H., Moreira, F. A., & de Oliveira, A. C. P. (2022) · Current Neuropharmacology · doi:10.2174/1570159x21666221208142151 · Cited by 26
Sex and interferon gamma signaling regulate microglia migration in the adult mouse cortex in vivo
Boghozian, R., Sharma, S., Narayana, K., Cheema, M. S., & Brown, C. E. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2302892120 · Cited by 24
Dissing‐Olesen, L., Walker, A. J., Feng, Q., Barr, H. J., Walker, A. C., Xie, L., Wilton, D. K., Das, I., Benowitz, L. I., & Stevens, B. (2023) · Nature Communications · doi:10.1038/s41467-023-41448-7 · Cited by 27
Integrity of neural extracellular matrix is required for microglia‐mediated synaptic remodeling
Cangalaya, C., Sun, W., Stoyanov, S., Dunay, I. R., & Dityatev, A. E. (2024) · Glia · doi:10.1002/glia.24588 · Cited by 27
Bloomfield, P. S., Bonsall, D. R., Wells, L. A., Dormann, D., Howes, O. D., & Paola, V. D. (2018) · Journal of Psychopharmacology · doi:10.1177/0269881118788830 · Cited by 25
Jiang, Y., Armada, K., & Martin, J. H. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.113015 · Cited by 26
Grovola, M. R., Paleologos, N., Wofford, K. L., Harris, J. P., Browne, K. D., Johnson, V. E., Duda, J. E., Wolf, J. A., & Cullen, D. K. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-1720-0 · Cited by 24
Contributions of Microglia to Structural Synaptic Plasticity
Kim, K. H., Son, S. M., & Mook‐Jung, I. (2013) · Journal of Experimental Neuroscience · doi:10.4137/jen.s11269 · Cited by 25
Synaptic pruning by microglia: lessons from genetic studies in mice
de Deus, J. L., Faborode, O. S., & Nandi, S. (2024) · Developmental Neuroscience · doi:10.1159/000541379 · Cited by 23
Peng, X., Mao, Y., Liu, Y., Dai, Q., Tai, Y., Luo, B., Liang, Y., Guan, R., Zhou, W., Chen, L., et al. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14674 · Cited by 24
Assessing Microglial Dynamics by Live Imaging
Andoh, M., & Koyama, R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.617564 · Cited by 23
Microglia in antiviral immunity of the brain and spinal cord
O’Brien, C. A., Bennett, F. C., & Bennett, M. L. (2022) · Seminars in Immunology · doi:10.1016/j.smim.2022.101650 · Cited by 26
Sullivan, O., & Ciernia, A. V. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.989011 · Cited by 23
Caruso, G., Pietro, L. D., & Caraci, F. (2023) · Biomolecules · doi:10.3390/biom13030505 · Cited by 24
Dundee, J. M., Puigdellívol, M., Butler, R., & Brown, G. C. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.1089-23.2023 · Cited by 23
Imaging microcircuit function in healthy and diseased brain
Garaschuk, O. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.02.009 · Cited by 24
Kapoor, K., Bhandare, A., Nedoboy, P. E., Mohammed, S., Farnham, M. M. J., & Pilowsky, P. M. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.04.044 · Cited by 23
Hui, C. W., Bhardwaj, S. K., Sharma, K. P., Joseph, A. T., Bisht, K., Picard, K., Tremblay, M., & Srivastava, L. K. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.12.007 · Cited by 23
Self-citationSpinal cord microglia in health and disease
Kolos, E. A., & Korzhevsky, D. (2020) · Acta Naturae · doi:10.32607/actanaturae.10934 · Cited by 25
Developmental functions of microglia: Impact of psychosocial and physiological early life stress
Smail, M. A., & Lenz, K. M. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110084 · Cited by 24
Lo, M.-C., Wang, S., Singh, S., Damodaran, V. B., Ahmed, I., Coffey, K. R., Barker, D., Saste, K., Kals, K., Kaplan, H. M., et al. (2018) · Journal of Neural Engineering · doi:10.1088/1741-2552/aa9fad · Cited by 22
In Vivo Imaging of the Microglial Landscape After Whole Brain Radiation Therapy
Whitelaw, B. S., Tanny, S., Johnston, C. J., Majewska, A. K., O’Banion, M. K., & Marples, B. (2021) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2021.07.038 · Cited by 22
Self-citationEmerging Roles of Microglia in Neuro-vascular Unit: Implications of Microglia-Neurons Interactions
Ding, Z., Guo, S., Luo, L., Zheng, Y., Gan, S., Kang, X., Wu, X., & Zhu, S. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.706025 · Cited by 23
Wang, Y., Li, J., Wang, M.-Y., Pan, Z.-Y., Li, Z., & Wang, Z.-F. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.03.122 · Cited by 22
Neuroglia Cells Transcriptomic in Brain Development, Aging and Neurodegenerative Diseases
Pinosanu, L. R., Căpitănescu, B., Glăvan, D., Godeanu, S., Fernández‐Cadenas, I., Doeppner, T. R., Hermann, D. M., Bălşeanu, T. A., Cătălin, B., & Popa‐Wagner, A. (2022) · Aging and Disease · doi:10.14336/ad.2022.0621 · Cited by 23
St‐Pierre, M., Ibáñez, F. G., Kroner, A., & Tremblay, M. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02953-0 · Cited by 22
Self-citationNishimura, N., & Schaffer, C. B. (2013) · Stroke · doi:10.1161/strokeaha.112.679621 · Cited by 23
Primary Cilia and Dendritic Spines: Different but Similar Signaling Compartments
Nechipurenko, I. V., Doroquez, D. B., & Sengupta, P. (2013) · Molecules and Cells · doi:10.1007/s10059-013-0246-z · Cited by 23
Physiological Functions of Glial Cell Hemichannels
Orellana, J. A. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-40764-7_5 · Cited by 22
Anderson, W. D., Greenhalgh, A. D., Takwale, A., David, S., & Vadigepalli, R. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00233 · Cited by 22
Acute ethanol exposure rapidly alters cerebellar and cortical microglial physiology
Stowell, R. D., & Majewska, A. K. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14706 · Cited by 22
Self-citationTau-Mediated Dysregulation of Neuroplasticity and Glial Plasticity
Koller, E. J., & Chakrabarty, P. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00151 · Cited by 23
von Saucken, V. E., Jay, T. R., & Landreth, G. E. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105072 · Cited by 22
Xia, C., Yin, M., Wu, C., Ji, Y., & Zhou, Y. (2020) · PubMed Central · Cited by 22
Adekomi, D., Aderinola, A. A., Tijani, A. A., Olaniyan, O. O., Olanike, A. M., & Ijomone, O. K. (2018) · Anatomy & Cell Biology · doi:10.5115/acb.2018.51.1.41 · Cited by 22
The Pelvic Girdle Pain deadlock: 2. Topics that, so far, have remained out of focus
Meijer, O. G., Barbe, M. F., Prins, M. R., Schipholt, I. J. L., Hu, H., & Daffertshofer, A. (2020) · Musculoskeletal Science and Practice · doi:10.1016/j.msksp.2020.102166 · Cited by 22
Key roles of glial cells in the encephalopathy of prematurity
Steenwinckel, J. V., Bokobza, C., Laforge, M., Shearer, I. K., Miron, V. E., Rua, R., Matta, S. M., Hill‐Yardin, E. L., Fleiss, B., & Gressèns, P. (2023) · Glia · doi:10.1002/glia.24474 · Cited by 26
Glial Cell Modulation of Dendritic Spine Structure and Synaptic Function
Rasia‐Filho, A. A., Calcagnotto, M. E., & Halbach, O. V. B. U. (2023) · Advances in neurobiology · doi:10.1007/978-3-031-36159-3_6 · Cited by 21
Bobotis, B. C., Halvorson, T., Carrier, M., & Tremblay, M. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1317125 · Cited by 22
Self-citationAkinlaja, Y. O., & Nishiyama, A. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1418100 · Cited by 23
The Role of Activity in Synaptic Degeneration in a Protein Misfolding Disease, Prion Disease
Caleo, M., Restani, L., Vannini, E., Šišková, Z., Al-Malki, H., Morgan, R. S. M., O'Connor, V. M., & Perry, V. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041182 · Cited by 21
Microglia Under the Spotlight: Activity and Complement-Dependent Engulfment of Synapses
Thion, M. S., & Garel, S. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2018.03.017 · Cited by 23
Rosin, J. M., & Kurrasch, D. M. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1213-6 · Cited by 21
Shoham, S., Linial, M., & Weinstock, M. (2018) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-018-9817-2 · Cited by 21
DiBona, V. L., Zhu, W., Shah, M. K., Rafalia, A., Cheikh, H. B., Crockett, D. P., & Zhang, H. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1390-3 · Cited by 21
Soch, A., Sominsky, L., Younesi, S., Luca, S. N. D., Gunasekara, M., Bozinovski, S., & Spencer, S. J. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.04.082 · Cited by 21
Creating Space for Synaptic Formation—A New Role for Microglia in Synaptic Plasticity
Zaki, Y., & Cai, D. J. (2020) · Cell · doi:10.1016/j.cell.2020.06.042 · Cited by 22
Stoyanov, S., Sun, W., Düsedau, H. P., Cangalaya, C., Choi, I., Mirzapourdelavar, H., Baidoe‐Ansah, D., Kaushik, R., Neumann, J. H. L., Dunay, I. R., et al. (2020) · Glia · doi:10.1002/glia.23894 · Cited by 21
3D brain tissue physiological model with co-cultured primary neurons and glial cells in hydrogels
Raimondi, I., Tunesi, M., Forloni, G., Albani, D., & Giordano, C. (2020) · Journal of Tissue Engineering · doi:10.1177/2041731420963981 · Cited by 22
Church, J. S., Tamayo, J. M., Ashwood, P., & Schwartzer, J. J. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.12.014 · Cited by 22
Pathways linking Alzheimer’s disease risk genes expressed highly in microglia
Hodges, A. K., Piers, T. M., Collier, D., Cousins, O., & Pocock, J. M. (2021) · Neuroimmunology and Neuroinflammation · doi:10.20517/2347-8659.2020.60 · Cited by 21
Synaptic Function and Dysfunction in Lysosomal Storage Diseases
Rebiai, R., Givogri, M. I., Gowrishankar, S., Cologna, S. M., Alford, S. T., & Bongarzone, E. R. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.619777 · Cited by 21
Zheng, Z., Liang, P., Hou, B., Lu, X., Ma, Q., Yu, X.-M., Han, S. H., Peng, B., Chen, T.-X., Liu, W., et al. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02133-y · Cited by 22
Alzheimer’s Disease, Sleep Disordered Breathing, and Microglia: Puzzling out a Common Link
Ulland, T. K., Ewald, A. C., Knutson, A. O., Marino, K. M., Smith, S. M. C., & Watters, J. J. (2021) · Cells · doi:10.3390/cells10112907 · Cited by 21
Both heat-sensitive TRPV4 and cold-sensitive TRPM8 ion channels regulate microglial activity
Chakraborty, R., & Goswami, C. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.04.032 · Cited by 21
Do Microglia default on network maintenance in Alzheimer's disease?
Southam, K. A., Vincent, A. J., & Small, D. H. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-151075 · Cited by 20
Laabi, S., LeMmon, C., Vogel, C., Chacon, M., & Jimenez, V. M. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114940 · Cited by 20
Cohen, E. M., Mohammed, S., Kavurma, M. M., Nedoboy, P. E., Cartland, S. P., Farnham, M. M. J., & Pilowsky, P. M. (2018) · Autonomic Neuroscience · doi:10.1016/j.autneu.2018.12.002 · Cited by 20
Strategies and Tools for Studying Microglial-Mediated Synapse Elimination and Refinement
Morini, R., Bizzotto, M., Perrucci, F., Filipello, F., & Matteoli, M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.640937 · Cited by 22
Avalos, M. P., Guzman, A. S., Rigoni, D., Gorostiza, E. A., Sanchez, M. A., Mongi‐Bragato, B., García‐Keller, C., Perassi, E. M., Virgolini, M. B., Ramos, J. M. P., et al. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.01.014 · Cited by 20
Microglial FABP4-UCP2 Axis Modulates Neuroinflammation and Cognitive Decline in Obese Mice
So, S. W., Fleming, K. M., Duffy, C. M., Nixon, J. P., Bernlohr, D., & Butterick, T. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084354 · Cited by 21
Surprises from Intravital Imaging of the Innate Immune Response
Mihlan, M., Safaiyan, S., Stecher, M., Paterson, N., & Lämmermann, T. (2022) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-120420-112849 · Cited by 21
Mathews, M., Wißfeld, J., Flitsch, L. J., Shahraz, A., Semkova, V., Breitkreuz, Y., Neumann, H., & Brüstle, O. (2022) · Stem Cell Reviews and Reports · doi:10.1007/s12015-022-10433-w · Cited by 20
Fröhlich, A., Heuvel, F. O., Rehman, R., Krishnamurthy, S. S., Li, S., Li, Z., Bayer, D., Conquest, A., Hagenston, A. M., Ludolph, A. C., et al. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02634-4 · Cited by 20
The Role of Microglial Depletion Approaches in Pathological Condition of CNS
Tahmasebi, F., & Barati, S. (2023) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-023-01326-8 · Cited by 21
Vicente, M. C., Paneghini, J. D. L., Stabile, A. M., Amorim, M. R., Silva, C. E. A., Patrone, L. G. A., Cunha, T. M., Bícego, K. C., Almeida, M. C., Carrettiero, D. C., et al. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230151 · Cited by 21
Peng, M., Zou, R., Yao, S., Meng, X., Wu, W., Zeng, F., Chen, Z., Yuan, S., Zhao, F., & Liu, W. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122871 · Cited by 20
Filho, C. S., de Lima, C. M., Fôro, C. A. R., Augusto‐Oliveira, M., Magalhães, N. G. D. M., Diniz, C. G., Diniz, D. G., Vasconcelos, P. F. D. C., & Diniz, C. W. P. (2014) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2014.10.001 · Cited by 21
Guo, L., Rezvanian, A., Kukreja, L., Hoveydai, R., Bigio, E. H., Mesulam, M. M., Khoury, J. B. E., & Geula, C. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160394 · Cited by 21
Characterization of macrophages from schizophrenia patients
Ormel, P. R., van Mierlo, H. C., Litjens, M., van Strien, M. E., Hol, E. M., Kahn, R. S., & de Witte, L. D. (2017) · Schizophrenia · doi:10.1038/s41537-017-0042-4 · Cited by 22
de Oliveira, T. C. G., Paulo, D. C., de Lima, C. M., de Oliveira, R. B., Filho, C. S., Diniz, D. G., Bento‐Torres, J., & Diniz, C. W. P. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14920 · Cited by 21
Perry, V. H. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.mchd-0003-2015 · Cited by 21
Ultrastructural Analyses of Microglial Interactions with Synapses
Tremblay, M.-È., & Majewska, A. K. (2019) · Methods in Molecular Biology · doi:10.1007/978-1-4939-9658-2_7 · Cited by 20
Self-citationMicroglial modulation of neuronal network function and plasticity
Peña‐Ortega, F. (2025) · Journal of Neurophysiology · doi:10.1152/jn.00458.2024 · Cited by 19
Type I interferon signalling and interferon‐responsive microglia in health and disease
López‐Atalaya, J. P., & Bhojwani-Cabrera, A. M. (2025) · FEBS Journal · doi:10.1111/febs.70126 · Cited by 23
González, G. M., Hart, B. A. ‘., Bugiani, M., Plemel, J. R., Schenk, G. J., Kooij, G., & Luchicchi, A. (2025) · Acta Neuropathologica · doi:10.1007/s00401-025-02923-1 · Cited by 20
Roman, K. M., Jenkins, A. K., Lewis, D. A., & Volk, D. W. (2021) · Translational Psychiatry · doi:10.1038/s41398-020-01092-x · Cited by 20
Chen, C., & Brumberg, J. C. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.770453 · Cited by 18
The versatile role of TREM2 in regulating of microglia fate in the ischemic stroke
Ma, W.-Y., Wang, S., Wu, Q.-L., Zhou, X., Chu, S., & Chen, N. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108733 · Cited by 20
The role of the neuronal microenvironment in sensory function and pain pathophysiology
Starobova, H., Alshammari, A., Winkler, I. G., & Vetter, I. (2022) · Journal of Neurochemistry · doi:10.1111/jnc.15724 · Cited by 19
Sheridan, S. D., Horng, J. E., Yeh, H., McCrea, L. T., Wang, J. P., Fu, T., & Perlis, R. H. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.07.022 · Cited by 19
Metadata
- Authors
- Tremblay, M.-È., Lowery, R. L., & Majewska, A. K.
- Affiliations
- University of Rochester Medicine (US)
- Corresponding author
- Tremblay, Marie-Ève
- Majewska, Ania K.
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2010-11-02
- Volume
- 8
- Issue
- 11
- Pages
- e1000527
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- PMC
- PMC2970556
- OpenAlex
- W2066943555
- Cited by
- 1,542
- References
- 79
- Citations by year
- 2026: 62 · 2025: 74 · 2024: 127 · 2023: 90 · 2022: 122 · 2021: 145 · 2020: 127 · 2019: 149 · 2018: 107 · 2017: 97 · 2016: 101 · 2015: 95 · 2014: 103 · 2013: 66 · 2012: 48
- FWCI
- 27.48
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS Biology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- Burroughs Wellcome Fund
- Alfred P. Sloan Foundation
- University of Rochester
- Stiftung für die Erforschung der Muskelkrankheiten
- National Institutes of Health
- Medical Center, University of Rochester
- National Eye Institute (R01EY019277, EY019277)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- microglia, synapses, visual cortex, sensory experience, light deprivation, dendritic spines, synaptic cleft, extracellular space, microglial motility, phagocytosis, experience-dependent synaptic plasticity, synaptic pruning, juvenile mice
- MeSH terms
- Animals, Extracellular Space, Microscopy, Electron, Synapses, Vision, Ocular, Microglia, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
