Cited by 20Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Do Microglia default on network maintenance in Alzheimer's disease?

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Southam, Katherine A., Vincent, Adele J., Small, David H.·2016·Journal of Alzheimer s Disease

Abstract

Although the cause of Alzheimer's disease (AD) remains unknown, a number of new findings suggest that the immune system may play a critical role in the early stages of the disease. Genome-wide association studies have identified a wide array of risk-associated genes for AD, many of which are associated with abnormal functioning of immune cells. Microglia are the brain's immune cells. They play an important role in maintaining the brain's extracellular environment, including clearance of aggregated proteins such as amyloid-β (Aβ). Recent studies suggest that microglia play a more active role in the brain than initially considered. Specifically, microglia provide trophic support to neurons and also regulate synapses. Microglial regulation of neuronal activity may have important consequences for AD. In this article we review the function of microglia in AD and examine the possible relationship between microglial dysfunction and network abnormalities, which occur very early in disease pathogenesis.

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Authors
Southam, K. A., Vincent, A. J., & Small, D. H.
Affiliations
University of Tasmania (AU)
Corresponding author
Southam, Katherine A.
Venue
Journal of Alzheimer s Disease
Published
2016-03-30
Volume
51
Issue
3
Pages
657-669
ISSN
  • 1387-2877 (ISSN-L)
  • 1875-8908
OpenAlex
W2275287389
Cited by
20
References
155
Citations by year
2024: 2 · 2023: 1 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 9
FWCI
0.38
Type
journal article
Language
en
Open access
Locations
  • Journal of Alzheimer s Disease (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • eCite Digital Repository (University of Tasmania) (submittedVersion, cc-by-nc)
  • Figshare (submittedVersion, cc-by-nc)
Funders
National Health and Medical Research Council
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
microglia, Alzheimer's disease
MeSH terms
Alzheimer Disease, Animals, Humans, Synapses, Microglia

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