The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Hydrogen Peroxide Promotes Injury-Induced Peripheral Sensory Axon Regeneration in the Zebrafish Skin
Open accessAbstract
Functional recovery from cutaneous injury requires not only the healing and regeneration of skin cells but also reinnervation of the skin by somatosensory peripheral axon endings. To investigate how sensory axon regeneration and wound healing are coordinated, we amputated the caudal fins of zebrafish larvae and imaged somatosensory axon behavior. Fin amputation strongly promoted the regeneration of nearby sensory axons, an effect that could be mimicked by ablating a few keratinocytes anywhere in the body. Since injury produces the reactive oxygen species hydrogen peroxide (H(2)O(2)) near wounds, we tested whether H(2)O(2) influences cutaneous axon regeneration. Exposure of zebrafish larvae to sublethal levels of exogenous H(2)O(2) promoted growth of severed axons in the absence of keratinocyte injury, and inhibiting H(2)O(2) production blocked the axon growth-promoting effects of fin amputation and keratinocyte ablation. Thus, H(2)O(2) signaling helps coordinate wound healing with peripheral sensory axon reinnervation of the skin.
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Cites
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989
Gurtner, G. C., Werner, S., Barrandon, Y., & Longaker, M. T. (2008) · Nature · doi:10.1038/nature07039 · Cited by 6,542
Functional regeneration after laser axotomy
Yanik, M. F., Cinar, H., Cinar, H. N., Chisholm, A. D., Jin, Y., & Ben-Yakar, A. (2004) · Nature · doi:10.1038/432822a · Cited by 598 · cited 1×
“elegans and zebrafish have utilized laser axotomy to precisely damage single axons in the peripheral nervous system, making it possible to assess the influence of nonneuronal tissues on axonal regeneration [9,10].”
BackgroundLe Guellec, D., Morvan-Dubois, G., & Sire, J.-Y. (2004) · The International Journal of Developmental Biology · doi:10.1387/ijdb.15272388 · Cited by 286
Harsum, S., Clarke, J. D. W., & Martin, P. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0395 · Cited by 65
Cited by
Reactive Oxygen Species Signaling and Oxidative Stress: Transcriptional Regulation and Evolution
Hong, Y., Boiti, A., Vallone, D., & Foulkes, N. S. (2024) · Antioxidants · doi:10.3390/antiox13030312 · Cited by 696
Hervera, A., De Virgiliis, F., Palmisano, I., Zhou, L., Tantardini, E., Kong, G., Hutson, T., Danzi, M. C., Perry, R. B.-T., Santos, C. X. C., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0039-x · Cited by 331
Gauron, C., Rampon, C., Bouzaffour, M., Ipendey, E., Teillon, J., Volovitch, M., & Vriz, S. (2013) · Scientific Reports · doi:10.1038/srep02084 · Cited by 291
The role of transcription-independent damage signals in the initiation of epithelial wound healing
Cordeiro, J. V., & Jacinto, A. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3541 · Cited by 273
Pase, L., Layton, J. E., Wittmann, C., Ellett, F., Nowell, C. J., Reyes-Aldasoro, C. C., Varma, S., Rogers, K. L., Hall, C. J., Keightley, M. C., et al. (2012) · Current Biology · doi:10.1016/j.cub.2012.07.060 · Cited by 118
Metadata
- Authors
- Rieger, S., & Sagasti, A.
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-05-24
- Volume
- 9
- Issue
- 5
- Pages
- e1000621
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- OpenAlex
- W1997136553
- Cited by
- 173
- References
- 5
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- gold
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- Rieger, S., & Sagasti, A. (2011). Hydrogen Peroxide Promotes Injury-Induced Peripheral Sensory Axon Regeneration in the Zebrafish Skin. PLoS Biology. https://doi.org/10.1371/journal.pbio.1000621
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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