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The Fifth Adaptor Protein Complex
Open accessAbstract
Adaptor protein (AP) complexes sort cargo into vesicles for transport from one membrane compartment of the cell to another. Four distinct AP complexes have been identified, which are present in most eukaryotes. We report the existence of a fifth AP complex, AP-5. Tagged AP-5 localises to a late endosomal compartment in HeLa cells. AP-5 does not associate with clathrin and is insensitive to brefeldin A. Knocking down AP-5 subunits interferes with the trafficking of the cation-independent mannose 6-phosphate receptor and causes the cell to form swollen endosomal structures with emanating tubules. AP-5 subunits can be found in all five eukaryotic supergroups, but they have been co-ordinately lost in many organisms. Concatenated phylogenetic analysis provides robust resolution, for the first time, into the evolutionary order of emergence of the adaptor subunit families, showing AP-3 as the basal complex, followed by AP-5, AP-4, and AP-1 and AP-2. Thus, AP-5 is an evolutionarily ancient complex, which is involved in endosomal sorting, and which has links with hereditary spastic paraplegia.
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“Strikingly, the majority of the proteins they encode have a role in intracellular membrane traffic, with at least 8 HSP proteins localising to endosomes [6,7].”
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“Strikingly, the majority of the proteins they encode have a role in intracellular membrane traffic, with at least 8 HSP proteins localising to endosomes [6,7].”
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RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models
Stamatakis, A. (2006) · Bioinformatics · doi:10.1093/bioinformatics/btl446 · Cited by 15,582
ProtTest: selection of best-fit models of protein evolution
Abascal, F., Zardoya, R., & Posada, D. (2005) · Bioinformatics · doi:10.1093/bioinformatics/bti263 · Cited by 3,063
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Bowman, S. L., Bi‐Karchin, J., Le, L., & Marks, M. S. (2019) · Traffic · doi:10.1111/tra.12646 · Cited by 219
A comparison of brain gene expression levels in domesticated and wild animals
Albert, F. W., Somel, M., Carneiro, M., Aximu-Petri, A., Halbwax, M., Thalmann, O., Blanco-Aguiar, J. A., Plyusnina, I. Z., Trut, L., Villafuerte, R., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002962 · Cited by 154
Park, M., Song, K., Reichardt, I., Kim, H., Mayer, U., Stierhof, Y.-D., Hwang, I., & Jürgens, G. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300460110 · Cited by 134
Spoiled for Choice: Diverse Endocytic Pathways Function at the Cell Surface
Thottacherry, J. J., Sathe, M., Prabhakara, C., & Mayor, S. (2019) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100617-062710 · Cited by 122
Metadata
- Authors
- Hirst, J., D. Barlow, L., Francisco, G. C., Sahlender, D. A., Seaman, M. N. J., Dacks, J. B., & Robinson, M. S.
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-10-11
- Volume
- 9
- Issue
- 10
- Pages
- e1001170
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- OpenAlex
- W2023404116
- Cited by
- 306
- References
- 2
- FWCI
- 14.70
- Type
- journal article
- Language
- en
- Open access
- gold
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- Hirst, J., D. Barlow, L., Francisco, G. C., Sahlender, D. A., Seaman, M. N. J., Dacks, J. B., & Robinson, M. S. (2011). The Fifth Adaptor Protein Complex. PLoS Biology. https://doi.org/10.1371/journal.pbio.1001170
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