A comparison of brain gene expression levels in domesticated and wild animals
Open accessAbstract
Domestication has led to similar changes in morphology and behavior in several animal species, raising the question whether similarities between different domestication events also exist at the molecular level. We used mRNA sequencing to analyze genome-wide gene expression patterns in brain frontal cortex in three pairs of domesticated and wild species (dogs and wolves, pigs and wild boars, and domesticated and wild rabbits). We compared the expression differences with those between domesticated guinea pigs and a distant wild relative (Cavia aperea) as well as between two lines of rats selected for tameness or aggression towards humans. There were few gene expression differences between domesticated and wild dogs, pigs, and rabbits (30-75 genes (less than 1%) of expressed genes were differentially expressed), while guinea pigs and C. aperea differed more strongly. Almost no overlap was found between the genes with differential expression in the different domestication events. In addition, joint analyses of all domesticated and wild samples provided only suggestive evidence for the existence of a small group of genes that changed their expression in a similar fashion in different domesticated species. The most extreme of these shared expression changes include up-regulation in domesticates of SOX6 and PROM1, two modulators of brain development. There was almost no overlap between gene expression in domesticated animals and the tame and aggressive rats. However, two of the genes with the strongest expression differences between the rats (DLL3 and DHDH) were located in a genomic region associated with tameness and aggression, suggesting a role in influencing tameness. In summary, the majority of brain gene expression changes in domesticated animals are specific to the given domestication event, suggesting that the causative variants of behavioral domestication traits may likewise be different.
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Significant brain gene expression differences exist across domesticates, with the majority of these changes being species-specific.
“This state of affairs is reflected in significant brain gene expression differences across domesticates, with the majority of these changes being species-specific [121].”
From Self-domestication in Homo sapiens: Insights from comparative genomics (2017) · cites this paper as [121]
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- Authors
- Albert, F. W., Somel, M., Carneiro, M., Aximu-Petri, A., Halbwax, M., Thalmann, O., Blanco-Aguiar, J. A., Plyusnina, I. Z., Trut, L., Villafuerte, R., Ferrand, N., Kaiser, S., Jensen, P., & Pääbo, S.
- Affiliations
- Princeton University (US)
- Chinese Academy of Sciences (CN)
- Universidade do Porto (PT)
- Kibale Chimpanzee Project (UG)
- University of Turku (FI)
- Institute of Cytology and Genetics (RU)
- Instituto de Investigación en Recursos Cinegéticos (ES)
- University of Münster (DE)
- Linköping University (SE)
- Max Planck Institute for Evolutionary Anthropology (DE)
- Corresponding author
- Albert, Frank W.
- ORCID
- Venue
- PLoS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-09-27
- Volume
- 8
- Issue
- 9
- Pages
- e1002962
- ISSN
- 1553-7390 (ISSN-L)
- 1553-7404
- PMC
- PMC3459979
- OpenAlex
- W2043798190
- Cited by
- 154
- References
- 96
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 4 · 2023: 10 · 2022: 12 · 2021: 18 · 2020: 19 · 2019: 7 · 2018: 10 · 2017: 12 · 2016: 17 · 2015: 10 · 2014: 15 · 2013: 6 · 2012: 1
- FWCI
- 6.17
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS Genetics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- KTH Publication Database DiVA (KTH Royal Institute of Technology) (submittedVersion, other-oa)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- OpenMETU (Middle East Technical University) (submittedVersion, cc-by-nc-nd)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Funders
- Deutsche Forschungsgemeinschaft
- National Natural Science Foundation of China
- Max-Planck-Gesellschaft
- FP7 Ideas: European Research Council (233297)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Human-Animal Interaction Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Keywords
- animal domestication, brain gene expression, frontal cortex, rabbits, guinea pig, Cavia aperea, tameness, aggression, SOX6, CD133, DLL3, gene expression differences
- MeSH terms
- AC133 Antigen, Animals, Animals, Domestic, Animals, Wild, Behavior, Animal, Brain, Dogs, Glycoproteins, Guinea Pigs, Peptides, Rabbits, Antigens, CD, Gene Expression, Wolves, Sus scrofa, Rats, SOXD Transcription Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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