Mapping Differentiation under Mixed Culture Conditions Reveals a Tunable Continuum of T Cell Fates

Antebi, Yaron E.; Reich-Zeliger, Shlomit; Hart, Yuval; Mayo, Avi; Eizenberg, Inbal; Rimer, Jacob; Putheti, Prabhakar; Pe'er, Dana; Friedman, Nir

doi:10.1371/journal.pbio.1001616

Mapping Differentiation under Mixed Culture Conditions Reveals a Tunable Continuum of T Cell Fates

An experimental and theoretical study of T cell differentiation in response to mixed-input conditions reveals that cells can tune between Th1 and Th2 states through a continuum of mixed phenotypes.