Cited by 115Evolution and Genetic DynamicsEvolutionary Algorithms and ApplicationsEvolutionary Game Theory and Cooperation

Coevolution Drives the Emergence of Complex Traits and Promotes Evolvability

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Zaman, Luis, Meyer, Justin R., Devangam, Suhas, Bryson, David M., Lenski, Richard E., Ofria, Charles·2014·PLoS Biology

Abstract

The evolution of complex organismal traits is obvious as a historical fact, but the underlying causes--including the role of natural selection--are contested. Gould argued that a random walk from a necessarily simple beginning would produce the appearance of increasing complexity over time. Others contend that selection, including coevolutionary arms races, can systematically push organisms toward more complex traits. Methodological challenges have largely precluded experimental tests of these hypotheses. Using the Avida platform for digital evolution, we show that coevolution of hosts and parasites greatly increases organismal complexity relative to that otherwise achieved. As parasites evolve to counter the rise of resistant hosts, parasite populations retain a genetic record of past coevolutionary states. As a consequence, hosts differentially escape by performing progressively more complex functions. We show that coevolution's unique feedback between host and parasite frequencies is a key process in the evolution of complexity. Strikingly, the hosts evolve genomes that are also more phenotypically evolvable, similar to the phenomenon of contingency loci observed in bacterial pathogens. Because coevolution is ubiquitous in nature, our results support a general model whereby antagonistic interactions and natural selection together favor both increased complexity and evolvability.

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  • In silico coevolution models, in vitro evolution and genomic analyses have shown that parasites actively promote diversity and evolvability.

    “In silico coevolution models [333,334], in vitro evolution [335,336] and genomic analyses [337,338] have shown that parasites actively promote diversity and evolvability, as illustrated by the phylogenetic trees in figure 9a,b.”

    From Fundamental constraints to the logic of living systems (2024) · cites this paper as [333]

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Authors
Zaman, L., Meyer, J. R., Devangam, S., Bryson, D. M., Lenski, R. E., & Ofria, C.
Affiliations
  • Michigan State University (US)
  • Harvard University (US)
  • Wayne State University (US)
Corresponding author
  • Zaman, Luis
  • Ofria, Charles
Venue
PLoS Biology
Published
2014-12-16
Volume
12
Issue
12
Pages
e1002023
ISSN
  • 1544-9173 (ISSN-L)
  • 1545-7885
OpenAlex
W2171848078
Cited by
115
References
44
Citations by year
2026: 4 · 2025: 4 · 2024: 3 · 2023: 11 · 2022: 8 · 2021: 14 · 2020: 12 · 2019: 5 · 2018: 9 · 2017: 14 · 2016: 17 · 2015: 13 · 2014: 1
FWCI
9.85
Type
journal article
Language
en
Open access
Locations
  • PLoS Biology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Science Foundation (0939454, 0643952)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
  • Physical Sciences › Computer Science › Artificial Intelligence › Evolutionary Algorithms and Applications
  • Social Sciences › Sociology and Political Science › Evolutionary Game Theory and Cooperation
Keywords
coevolution, evolution of complexity, evolvability, host-parasite arms race, Avida, digital evolution, antagonism, natural selection, host resistance, genome evolution
MeSH terms
Animals, Biological Evolution, Genotype, Host-Parasite Interactions, Parasites, Phylogeny, Time Factors, Genome, Point Mutation, Quantitative Trait, Heritable

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