The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Noise during Rest Enables the Exploration of the Brain's Dynamic Repertoire
Open accessAbstract
Traditionally brain function is studied through measuring physiological responses in controlled sensory, motor, and cognitive paradigms. However, even at rest, in the absence of overt goal-directed behavior, collections of cortical regions consistently show temporally coherent activity. In humans, these resting state networks have been shown to greatly overlap with functional architectures present during consciously directed activity, which motivates the interpretation of rest activity as day dreaming, free association, stream of consciousness, and inner rehearsal. In monkeys, it has been shown though that similar coherent fluctuations are present during deep anesthesia when there is no consciousness. Here, we show that comparable resting state networks emerge from a stability analysis of the network dynamics using biologically realistic primate brain connectivity, although anatomical information alone does not identify the network. We specifically demonstrate that noise and time delays via propagation along connecting fibres are essential for the emergence of the coherent fluctuations of the default network. The spatiotemporal network dynamics evolves on multiple temporal scales and displays the intermittent neuroelectric oscillations in the fast frequency regimes, 1-100 Hz, commonly observed in electroencephalographic and magnetoencephalographic recordings, as well as the hemodynamic oscillations in the ultraslow regimes, <0.1 Hz, observed in functional magnetic resonance imaging. The combination of anatomical structure and time delays creates a space-time structure in which the neural noise enables the brain to explore various functional configurations representing its dynamic repertoire.
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Cites
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“When subjects are not actively engaged in goal-directed mental activity, spontaneous brain activity has been suggested not to simply represent ‘‘noise’’, but rather implicate spontaneous and transient processes involved in task-unrelated imagery and thought [1–9].”
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Cited by
Local-global parcellation of the human cerebral cortex from intrinsic functional connectivity MRI
Schaefer, A., Kong, R., Gordon, E. M., Laumann, T. O., Zuo, X.-N., Holmes, A. J., Eickhoff, S. B., & Yeo, B. T. T. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhx179 · Cited by 3,657
Predicting human resting-state functional connectivity from structural connectivity
Honey, C. J., Sporns, O., Cammoun, L., Gigandet, X., Thiran, J. P., Meuli, R., & Hagmann, P. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811168106 · Cited by 3,307
DPARSF: a MATLAB toolbox for “pipeline” data analysis of resting-state fMRI
Yan (2010) · Frontiers in System Neuroscience · doi:10.3389/fnsys.2010.00013 · Cited by 3,475
Dynamic functional connectivity: Promise, issues, and interpretations
Hutchison, R. M., Womelsdorf, T., Allen, E. A., Bandettini, P. A., Calhoun, V. D., Corbetta, M., Della Penna, S., Duyn, J. H., Glover, G. H., Gonzalez-Castillo, J., et al. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.05.079 · Cited by 2,962
Van Dijk, K. R. A., Hedden, T., Venkataraman, A., Evans, K. C., Lazar, S. W., & Buckner, R. L. (2010) · Journal of Neurophysiology · doi:10.1152/jn.00783.2009 · Cited by 1,844
Metadata
- Authors
- Ghosh, A., Rho, Y., McIntosh, A. R., Kötter, R., & Jirsa, V. K.
- Venue
- PLoS Computational Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2008-10-10
- Volume
- 4
- Issue
- 10
- Pages
- e1000196
- ISSN
- 1553-734X (ISSN-L)
- 1553-7358
- OpenAlex
- W2064965260
- Cited by
- 564
- References
- 8
- FWCI
- 11.36
- Type
- journal article
- Language
- en
- Open access
- gold
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