Genetic Determinants of Human Health Span and Life Span: Progress and New Opportunities

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Epigenetic differences arise during the lifetime of monozygotic twins

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A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

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Evolution at Two Levels in Humans and Chimpanzees: Their macromolecules are so alike that regulatory mutations may account for their biological differences

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Complement factor H variant increases the risk of age-related macular degeneration

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A Century of Alzheimer's Disease

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IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

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Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome

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Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

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Measuring biological age using omics data

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Progeria syndromes and ageing: what is the connection?

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Substantial Health And Economic Returns From Delayed Aging May Warrant A New Focus For Medical Research

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Entropy Explains Aging, Genetic Determinism Explains Longevity, and Undefined Terminology Explains Misunderstanding Both

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Lifestyle Factors of People with Exceptional Longevity

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Aging in America in the Twenty‐first Century: Demographic Forecasts from the MacArthur Foundation Research Network on an Aging Society

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New model of health promotion and disease prevention for the 21st century

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Seven knowledge gaps in modern biogerontology

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Asynchrony of senescence among phenotypic traits in a wild mammal population

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The Epidemiology of Human Telomeres: Faults and Promises

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Genetic and epigenetic regulation of aging

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Zebrafish as a Genetic Model in Biological and Behavioral Gerontology: Where Development Meets Aging in Vertebrates – A Mini-Review

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Association of a Functional Polymorphism in the Cholesteryl Ester Transfer Protein ( CETP ) Gene With Memory Decline and Incidence of Dementia

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Subjective Wellbeing and Longevity: A Co-Twin Control Study

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Prospects for Life Span Extension

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Lipidomics in longevity and healthy aging

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Optimizing aging: A call for a new narrative.

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Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing

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Natural or pathologic? Discrepancies in the study of behavioral and cognitive signs in aging family dogs

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Silver paper: The future of health promotion and preventive actions, basic research, and clinical aspects of age-related disease

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DRD4 Genotype Predicts Longevity in Mouse and Human

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Developmental Drift and the Role of Wnt Signaling in Aging

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Aging and stress: past hypotheses, present approaches and perspectives.

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The ApoE Gene Is Related with Exceptional Longevity: A Systematic Review and Meta-Analysis

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Biogerontology: research status, challenges and opportunities.

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Common gene signature of cancer and longevity

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Cytogenetic perspective of ageing and longevity in men and women

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Trade-off in the effects of the apolipoprotein E polymorphism on the ages at onset of CVD and cancer influences human lifespan

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From cellular senescence to age-associated diseases: the miRNA connection

Schraml, E., & Grillari, J. (2012) · Longevity & Healthspan · doi:10.1186/2046-2395-1-10 · Cited by 47

Age-associated vulval integrity is an important marker of nematode healthspan

Leiser, S. F., Jafari, G., Primitivo, M., Sutphin, G. L., Dong, J., Leonard, A., Fletcher, M., & Kaeberlein, M. R. (2016) · AGE · doi:10.1007/s11357-016-9936-8 · Cited by 50

The Economic Promise of Delayed AgingPreprint

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Mood, Memory and Movement: An Age-Related Neurodegenerative Complex?

Granholm, A., Boger, H. A., & Emborg, M. E. (2008) · Current Aging Science · doi:10.2174/1874609810801020133 · Cited by 41

Precedents for the Biological Control of Aging: Experimental Postponement, Prevention, and Reversal of Aging Processes

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Prevention of Neuromusculoskeletal Frailty in Slow-Aging Ames Dwarf Mice: Longitudinal Investigation of Interaction of Longevity Genes and Caloric Restriction

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Genetics and Pharmacology of Longevity

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Are ‘Endurance’ Alleles ‘Survival’ Alleles? Insights from the ACTN3 R577X Polymorphism

Fiuza‐Luces, C., Ruiz, J. R., Rodríguez‐Romo, G., Santiago, C., Gómez‐Gallego, F., Yvert, T. P., Cano-Nieto, A., Garatachea, N., Morán, M., & Lucía, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017558 · Cited by 37

Definitions of healthspan: A systematic review

Masfiah, S., Kurnialandi, A., Meij, H. J., & Maier, A. B. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102806 · Cited by 37

Dietary polyphenols as geroprotective compounds: From Blue Zones to hallmarks of ageing

Davinelli, S., Medoro, A., Hu, F. B., & Scapagnini, G. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102733 · Cited by 34

Naive extrapolations, overhyped claims and empty promises in ageing research and interventions need avoidance

Rattan, S. I. S. (2019) · Biogerontology · doi:10.1007/s10522-019-09851-0 · Cited by 33

The ACE DD genotype and D-allele are associated with exceptional longevity: A meta-analysis

Garatachea, N., Marin, P. J., & Lucía, A. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.04.001 · Cited by 32

Toward a Systems Biology Framework for Understanding Aging and Health Span

West, G. B., & Bergman, A. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/gln066 · Cited by 34

Protective role of the apolipoprotein E2 allele in age-related disease traits and survival: evidence from the Long Life Family Study

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Mutation and the evolution of ageing: from biometrics to system genetics

Hughes, K. A. (2010) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2009.0265 · Cited by 31

Inside out: Relations between the microbiome, nutrition, and eye health

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High-Density Genomewide Linkage Analysis of Exceptional Human Longevity Identifies Multiple Novel Loci

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How the effects of aging and stresses of life are integrated in mortality rates: insights for genetic studies of human health and longevity

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Are mitochondrial haplogroups associated with extreme longevity? A study on a Spanish cohort

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Progress & Prospects: Gene therapy in aging

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Exposure to males, but not receipt of sex peptide, accelerates functional ageing in female fruit flies

Bretman, A. J., & Fricke, C. (2019) · Functional Ecology · doi:10.1111/1365-2435.13339 · Cited by 26

Genetic determinants of ageing processes and diseases in later life

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Unraveling Genetic Origin of Aging-Related Traits: Evolving Concepts

Kulminski, A. M. (2013) · Rejuvenation Research · doi:10.1089/rej.2013.1441 · Cited by 23

Association of the K153R polymorphism in the myostatin gene and extreme longevity

Garatachea, N., Pinós, T., Cámara, Y., Rodríguez‐Romo, G., Emanuele, E., Ricevuti, G., Venturini, L., Santos‐Lozano, A., Santiago, C., Fiuza‐Luces, C., et al. (2013) · AGE · doi:10.1007/s11357-013-9513-3 · Cited by 23

How pleiotropic genetics of the musculoskeletal system can inform genomics and phenomics of aging

Karasik, D. (2010) · AGE · doi:10.1007/s11357-010-9159-3 · Cited by 24

[The biology of aging].

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Molecular and chemical genetic approaches to developmental origins of aging and disease in zebrafish

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Genomics of human health and aging

Kulminski, A. M., & Culminskaya, I. V. (2011) · AGE · doi:10.1007/s11357-011-9362-x · Cited by 21

Is the ACE I/D polymorphism associated with extreme longevity? A study on a Spanish cohort

Fiuza‐Luces, C., Ruiz, J. R., Rodríguez‐Romo, G., Santiago, C., Gómez‐Gallego, F., Cano-Nieto, A., Garatachea, N., Rodríguez-Moreno, I., Morán, M., & Lucía, A. (2011) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320310391505 · Cited by 19

“Predicting” parental longevity from offspring endophenotypes: Data from the Long Life Family Study (LLFS)

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A brief history of modern aging research

Zainabadi, K. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.01.018 · Cited by 20

Contemporary human genetic strategies in aging research

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Trade-Offs in the Effects of the Apolipoprotein E Polymorphism on Risks of Diseases of the Heart, Cancer, and Neurodegenerative Disorders: Insights on Mechanisms from the Long Life Family Study

Kulminski, A. M., Arbeev, K. G., Culminskaya, I. V., Ukraintseva, S. V., Stallard, E., Province, M. A., & Yashin, A. I. (2014) · Rejuvenation Research · doi:10.1089/rej.2014.1616 · Cited by 17

Genetic interplay between human longevity and metabolic pathways — a large‐scale eQTL study

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Healthspan pathway maps in C. elegans and humans highlight transcription, proliferation/biosynthesis and lipids

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Evolutionary Genetic Bases of Longevity and Senescence

Govindaraju, D. R. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-2404-2_1 · Cited by 16

Are centenarians genetically predisposed to lower disease risk?

Ruiz, J. R., Fiuza‐Luces, C., Buxens, A., Cano-Nieto, A., Gómez‐Gallego, F., Santiago, C., Rodríguez‐Romo, G., Garatachea, N., Lao, J. I., Morán, M., et al. (2011) · AGE · doi:10.1007/s11357-011-9296-3 · Cited by 16

Pharmacogenetics and Pharmagenomics, Trends in Normal and Pathological Aging Studies: Focus on p53

Lanni, C., Racchi, M., Uberti, D. L., Mazzini, G., Stanga, S., Sinforiani, E., Memo, M., & Govoni, S. M. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208786264133 · Cited by 16

Genetic Polymorphisms and Human Aging: Association Studies Deliver

Melzer, D. (2008) · Rejuvenation Research · doi:10.1089/rej.2008.0684 · Cited by 15

Molecular Basis and Emerging Strategies for Anti-aging Interventions

Rattan, S. (2018) · Springer eBooks · doi:10.1007/978-981-13-1699-9 · Cited by 15

Gender-Specific DNA Methylome Analysis of a Han Chinese Longevity Population

Sun, L., Lin, J., Du, H., Hu, C., Huang, Z., Lv, Z., Zheng, C., Shi, X., Zhang, Y., & Yang, Z. (2014) · BioMed Research International · doi:10.1155/2014/396727 · Cited by 14

Aging trajectories are trait- and sex-specific in the long-lived Alpine swift

Moullec, H., Reichert, S., & Bize, P. (2023) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2023.983266 · Cited by 14

The search for evolutionary developmental origins of aging in zebrafish: A novel intersection of developmental and senescence biology in the zebrafish model system

Kishi, S. (2011) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.20217 · Cited by 16

Complex phenotypes and phenomenon of genome-wide inter-chromosomal linkage disequilibrium in the human genome

Kulminski, A. M. (2011) · Experimental Gerontology · doi:10.1016/j.exger.2011.08.010 · Cited by 14

Using zebrafish models to explore genetic and epigenetic impacts on evolutionary developmental origins of aging

Kishi, S. (2013) · Translational research · doi:10.1016/j.trsl.2013.10.004 · Cited by 12

The polymorphism of the serotonin-2A receptor T102C is associated with age

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Pleiotropic Meta-Analysis of Age-Related Phenotypes Addressing Evolutionary Uncertainty in Their Molecular Mechanisms

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Biased survival expectations and behaviours: Does domain specific information matter?

Costa‐Font, J., & Vilaplana‐Prieto, C. (2022) · Journal of Risk and Uncertainty · doi:10.1007/s11166-022-09382-z · Cited by 12

Has the time come to take on time itself?

Farrelly, C. (2008) · BMJ · doi:10.1136/bmj.a414 · Cited by 11

Parental longevity correlates with offspring’s optimism in two cohorts of community-dwelling older subjects

Ottenheim, N. R., Kromhout, D., de Craen, A. J. M., Geleijnse, J. M., van der Mast, R. C., Zitman, F. G., Westendorp, R. G. J., Slagboom, P. E., & Giltay, E. J. (2011) · AGE · doi:10.1007/s11357-011-9236-2 · Cited by 11

Protective Effects of Familial Longevity Decrease With Age and Become Negligible for Centenarians

Gavrilova, N. S., & Gavrilov, L. A. (2021) · The Journals of Gerontology Series A · doi:10.1093/gerona/glab380 · Cited by 11

Disuse and Aging, 2009

Bortz, W. M. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp164 · Cited by 11

Health-Related Phenotypes and Longevity in Danish Twins

Kulminski, A. M., Arbeev, K. G., Culminskaya, I. V., Ukraintseva, S. V., Christensen, K., & Yashin, A. I. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/gln051 · Cited by 10

Biologie du vieillissement

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Physical Activity and Sedentary Behavior at the End of the Human Lifespan

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Less functional variants of TLR-1/-6/-10 genes are associated with age

Hamann, L., Kupčinskas, J., Berrocal-Almanza, L. C., Skiecevičienė, J., Franke, A., Nöthlings, U., & Schumann, R. R. (2015) · Immunity & Ageing · doi:10.1186/s12979-015-0034-z · Cited by 9

Absorption of orally administered gentamicin in infants with diarrhea.

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Genome integrity as a potential index of longevity in Ashkenazi Centenarian’s families

Andrawus, M., David, G. B., Terziyska, I., Sharvit, L. E., Bergman, A., Barzilai, N., Raj, S. M., Govindaraju, D. R., & Atzmon, G. (2024) · GeroScience · doi:10.1007/s11357-024-01178-0 · Cited by 8

Competing Risks

Goldman, D. P., Gaudette, É., & Cheng, W. (2016) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2015.12.005 · Cited by 10

Zebrafish Aging Models and Possible Interventions

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Inter-chromosomal level of genome organization and longevity-related phenotypes in humans

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