The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Pain Genes
Open accessAbstract
Pain, which afflicts up to 20% of the population at any time, provides both a massive therapeutic challenge and a route to understanding mechanisms in the nervous system. Specialised sensory neurons (nociceptors) signal the existence of tissue damage to the central nervous system (CNS), where pain is represented in a complex matrix involving many CNS structures. Genetic approaches to investigating pain pathways using model organisms have identified the molecular nature of the transducers, regulatory mechanisms involved in changing neuronal activity, as well as the critical role of immune system cells in driving pain pathways. In man, mapping of human pain mutants as well as twin studies and association studies of altered pain behaviour have identified important regulators of the pain system. In turn, new drug targets for chronic pain treatment have been validated in transgenic mouse studies. Thus, genetic studies of pain pathways have complemented the traditional neuroscience approaches of electrophysiology and pharmacology to give us fresh insights into the molecular basis of pain perception.
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Cites
Molecular mechanisms of nociception
Julius, D., & Basbaum, A. I. (2001) · Nature · doi:10.1038/35093019 · Cited by 2,685 · cited 1×
“Gene expression profiles differ between these groups, with functional distinctions (reviewed in [62]).”
BackgroundDiatchenko, L., Slade, G. D., Nackley, A. G., Bhalang, K., Sigurdsson, A., Belfer, I., Goldman, D., Xu, K., Shabalina, S. A., Shagin, D., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi013 · Cited by 1,280
Nackley, A. G., Shabalina, S. A., Tchivileva, I. E., Satterfield, K., Korchynskyi, O., Makarov, S. S., Maixner, W., & Diatchenko, L. (2006) · Science · doi:10.1126/science.1131262 · Cited by 848
Heritability of nociception I: Responses of 11 inbred mouse strains on 12 measures of nociception
Mogil, J. S., Wilson, S. G., Bon, K., Eun Lee, S., Chung, K., Raber, P., Pieper, J. O., Hain, H. S., Belknap, J. K., Hubert, L., et al. (1999) · Pain · doi:10.1016/s0304-3959(98)00197-3 · Cited by 656
Allelic Expression Imbalance of Human mu Opioid Receptor (OPRM1) Caused by Variant A118G
Zhang, Y., Wang, D., Johnson, A. D., Papp, A. C., & Sadée, W. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504942200 · Cited by 563
Cited by
Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment
Baron, R., Binder, A., & Wasner, G. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70143-5 · Cited by 1,816
Transition from acute to chronic postsurgical pain: risk factors and protective factors
Katz, J., & Seltzer, Z. (2009) · Expert Review of Neurotherapeutics · doi:10.1586/ern.09.20 · Cited by 782
A Gain-of-Function Mutation in TRPA1 Causes Familial Episodic Pain Syndrome
Kremeyer, B., Lopera, F., Cox, J. J., Momin, A., Rugiero, F., Marsh, S., Woods, C. G., Jones, N. G., Paterson, K. J., Fricker, F. R., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.04.030 · Cited by 443
Self-citationPostamputation pain: epidemiology, mechanisms, and treatment
Cohen, S., & Hsu (2013) · Journal of Pain Research · doi:10.2147/jpr.s32299 · Cited by 372
Negative affect heightens opiate withdrawal-induced hyperalgesia in heroin dependent individuals
Carcoba, L. M., Contreras, A. E., Cepeda-Benito, A., & Meagher, M. W. (2011) · Journal of Addictive Diseases · doi:10.1080/10550887.2011.581985 · Cited by 52
Metadata
- Authors
- Foulkes, T., & Wood, J. N.
- Venue
- PLoS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2008-07-25
- Volume
- 4
- Issue
- 7
- Pages
- e1000086
- ISSN
- 1553-7390 (ISSN-L)
- 1553-7404
- OpenAlex
- W4252839768
- Cited by
- 158
- References
- 5
- FWCI
- 7.44
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
