Allelic Expression Imbalance of Human mu Opioid Receptor (OPRM1) Caused by Variant A118G

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Adult attachment style is associated with cerebral μ‐opioid receptor availability in humans

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Current evidence for a genetic modulation of the response to analgesics

Lötsch, J., & Geißlinger, G. (2006) · Pain · doi:10.1016/j.pain.2006.01.010 · Cited by 132 · see citing works

A review of opioid addiction genetics

Crist, R. C., Reiner, B. C., & Berrettini, W. H. (2018) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2018.07.014 · Cited by 131 · see citing works

Differential Opioid Action on Sensory and Affective Cerebral Pain Processing

Oertel, B., Preibisch, C., Wallenhorst, T., Hummel, T. R., Geißlinger, G., Lanfermann, H., & Lötsch, J. (2007) · Clinical Pharmacology & Therapeutics · doi:10.1038/sj.clpt.6100441 · Cited by 131 · see citing works

μ-Opioid Receptor Gene A118G Polymorphism Predicts Survival in Patients with Breast Cancer

Bortsov, A. V., Millikan, R. C., Belfer, I., Boortz-Marx, R. L., Arora, H., & McLean, S. A. (2012) · Anesthesiology · doi:10.1097/aln.0b013e31824b96a1 · Cited by 129 · see citing works

Subjective Responses to Alcohol Consumption as Endophenotypes: Advancing Behavioral Genetics in Etiological and Treatment Models of Alcoholism

Ray, L. A., MacKillop, J., & Monti, P. M. (2010) · Substance Use & Misuse · doi:10.3109/10826084.2010.482427 · Cited by 128 · see citing works

Genetic contributions to pain: a review of findings in humans

Fillingim, R. B., Wallace, M. R., Herbstman, D. M., Ribeiro-Dasilva, M., & Staud, R. M. (2008) · Oral Diseases · doi:10.1111/j.1601-0825.2008.01458.x · Cited by 127 · see citing works

Cross-sectional analysis of the influence of currently known pharmacogenetic modulators on opioid therapy in outpatient pain centers

Lötsch, J., von Hentig, N., Freynhagen, R., Grießinger, N., Zimmermann, M., Doehring, A., Rohrbacher, M., Sittl, R., & Geißlinger, G. (2009) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e32832b89da · Cited by 124 · see citing works

Genetic–epigenetic interaction modulates µ-opioid receptor regulation

Oertel, B. G., Doehring, A., Roskam, B., Kettner, M., Hackmann, N., Ferreirós, N., Schmidt, P. H., & Lötsch, J. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds314 · Cited by 124 · see citing works

Association of OPRM1 A118G variant with the relative reinforcing value of nicotine

Ray, R., Jepson, C., Patterson, F., Strasser, A. A., Rukstalis, M. R., Perkins, K. A., Lynch, K. G., O’Malley, S. S., Berrettini, W. H., & Lerman, C. E. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0504-2 · Cited by 125 · see citing works

Polymorphisms of the μ-opioid receptor and dopamine D₄ receptor genes and subjective responses to alcohol in the natural environment.

Ray, L. A., Miranda, R., Tidey, J. W., McGeary, J. E., MacKillop, J. M., Gwaltney, C. J., Rohsenow, D. J., Swift, R. M., & Monti, P. M. (2010) · Journal of Abnormal Psychology · doi:10.1037/a0017550 · Cited by 125 · see citing works

Searching for polymorphisms that affect gene expression and mRNA processing: Example ABCB1 (MDR1)

Wang, D., & Sadée, W. (2006) · The AAPS Journal · doi:10.1208/aapsj080361 · Cited by 120 · see citing works

State-dependent μ-opioid modulation of social motivation

Løseth, G. E., Ellingsen, D., & Leknes, S. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00430 · Cited by 116 · see citing works

Tryptophan hydroxylase 2 (TPH2) haplotypes predict levels of TPH2 mRNA expression in human pons

Lim, J.-E., Pinsonneault, J. K., Sadée, W., & Saffen, D. W. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001923 · Cited by 119 · see citing works

Interindividual Variability of Methadone Response

Li, Y., Kantelip, J., Schieveen, P. G., & Davani, S. (2008) · Molecular Diagnosis & Therapy · doi:10.1007/bf03256276 · Cited by 117 · see citing works

Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts

Schwantes-An, T.-H. L., Zhang, J., Chen, L., Hartz, S. M., Culverhouse, R., Chen, X., Coon, H. H., Frank, J., Kamens, H. M., Konte, B., et al. (2015) · Behavior Genetics · doi:10.1007/s10519-015-9737-3 · Cited by 115 · see citing works

Allelic mRNA expression of X-linked monoamine oxidase a (MAOA) in human brain: dissection of epigenetic and genetic factors

Pinsonneault, J. K., Papp, A. C., & Sadée, W. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl192 · Cited by 114 · see citing works

A common single nucleotide polymorphism A118G of the μ opioid receptor alters its N-glycosylation and protein stability

Huang, P., Chen, C., Mague, S. D., Blendy, J. A., & Liu‐Chen, L. (2011) · Biochemical Journal · doi:10.1042/bj20111050 · Cited by 113 · see citing works

PharmGKB summary

Gong, L., Stamer, U. M., Tzvetkov, M. V., Altman, R. B., & Klein, T. E. (2014) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0000000000000057 · Cited by 113 · see citing works

Pharmacogenetics of OPRM1

Crist, R. C., & Berrettini, W. H. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.10.018 · Cited by 112 · see citing works

μ Opioid receptor A118G polymorphism in association with striatal opioid neuropeptide gene expression in heroin abusers

Drakenberg, K., Nikoshkov, A., Horváth, M., Fagergren, P., Gharibyan, A. L., Saarelainen, K., Rahman, S., Nylander, I., Bakalkin, G. Y., Rajs, J., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600871103 · Cited by 109 · see citing works

Predictors of Naltrexone Response in a Randomized Trial: Reward-Related Brain Activation, OPRM1 Genotype, and Smoking Status

Schacht, J. P., Randall, P. K., Latham, P. K., Voronin, K. E., Book, S. W., Myrick, H., & Anton, R. F. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.74 · Cited by 107 · see citing works

Highly variable mRNA expression and splicing of L-type voltage-dependent calcium channel alpha subunit 1C in human heart tissues

Wang, D., Papp, A. C., Binkley, P. F., Johnson, J. A., & Sadée, W. (2006) · Pharmacogenetics and Genomics · doi:10.1097/01.fpc.0000230119.34205.8a · Cited by 108 · see citing works

The Impact of Genetic Variation on Sensitivity to Opioid Analgesics in Patients with Postoperative Pain: A Systematic Review and Meta-Analysis

Lu, P. L. (2015) · Pain Physician · doi:10.36076/ppj/2015.18.131 · Cited by 106 · see citing works

Association of a Functional Polymorphism in the μ-Opioid Receptor Gene With Alcohol Response and Consumption in Male Rhesus Macaques

Barr, C. S., Schwandt, M., Lindell, S. G., Chen, S. A., Goldman, D., Suomi, S. J., Higley, J. D., & Heilig, M. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.3.369 · Cited by 105 · see citing works

Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment

Yuferov, V. P., Levran, O., Proudnikov, D., Nielsen, D. A., & Kreek, M. J. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05275.x · Cited by 104 · see citing works

Consequences of the 118A>G polymorphism in the OPRM1 gene: translation from bench to bedside?

Mura, E., Govoni, S. M., Racchi, M., Carossa, Ranzani, G. N., Allegri, M., & van Schaik, A. (2013) · Journal of Pain Research · doi:10.2147/jpr.s42040 · Cited by 105 · see citing works

Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues

Johnson, A. D., Zhang, Y., Papp, A. C., Pinsonneault, J. K., Lim, J.-E., Saffen, D. W., Zunyan Dai, Y., Wang, D., & Sadée, W. (2008) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e3283050107 · Cited by 105 · see citing works

Genetic modulation of the pharmacological treatment of pain

Lötsch, J., Geißlinger, G., & Tegeder, I. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.06.010 · Cited by 104 · see citing works

Single‐nucleotide polymorphism (A118G) in exon 1 ofOPRM1gene causes alteration in downstream signaling by mu‐opioid receptor and may contribute to the genetic risk for addiction

Deb, I., Chakraborty, J., Gangopadhyay, P. K., Choudhury, S. R., & Das, S. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06472.x · Cited by 104 · see citing works

Association of UGT2B7 and ABCB1 genotypes with morphine-induced adverse drug reactions in Japanese patients with cancer

Fujita, K., Ando, Y., Yamamoto, W., Miya, T., Endo, H., Sunakawa, Y., Araki, K., Kodama, K., Nagashima, F., Ichikawa, W., et al. (2009) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-009-1029-2 · Cited by 104 · see citing works

Pain Intensity the First Year after Lumbar Disc Herniation Is Associated with the A118G Polymorphism in the Opioid Receptor Mu 1 Gene: Evidence of a Sex and Genotype Interaction

Olsen, M. B., Jacobsen, L. M., Schistad, E. I., Pedersen, L. M., Rygh, L. J., Røe, C., & Gjerstad, J. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1742-12.2012 · Cited by 103 · see citing works

Alcohol Use Disorder: Neurobiology and Therapeutics

Yang, W., Singla, R., Maheshwari, O., Fontaine, C. J., & Gil‐Mohapel, J. (2022) · Biomedicines · doi:10.3390/biomedicines10051192 · Cited by 111 · see citing works

Neuropathic and chronic pain stimuli downregulate central μ -opioid and dopaminergic transmission

Niikura, K., Narita, M., Butelman, E. R., Kreek, M. J., & Suzuki, T. (2010) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2010.04.003 · Cited by 103 · see citing works

The opioid system in depression

Jelen, L. A., Stone, J. M., Young, A. H., & Mehta, M. A. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104800 · Cited by 102 · see citing works

Naltrexone Alone and With Sertraline for the Treatment of Alcohol Dependence in Alaska Natives and Non‐Natives Residing in Rural Settings: A Randomized Controlled Trial

O’Malley, S. S., Robin, R. W., Levenson, A. L., GreyWolf, I., Chance, L. E., Hodgkinson, C. A., Romano, D. M., Robinson, J., Meandzija, B., Stillner, V., et al. (2008) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00682.x · Cited by 101 · see citing works

Epigenetic Variation in the Mu-Opioid Receptor Gene in Infants with Neonatal Abstinence Syndrome

Wachman, E. M., Hayes, M. J., Lester, B. M., Terrin, N. C., Brown, M. S., Nielsen, D. A., & Davis, J. M. (2014) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2014.05.040 · Cited by 100 · see citing works

Pharmacogenetic Insights into Codeine Analgesia: Implications to Pediatric Codeine Use

Madadi, P., & Koren, G. (2008) · Pharmacogenomics · doi:10.2217/14622416.9.9.1267 · Cited by 96 · see citing works

Targeting opioid dysregulation in depression for the development of novel therapeutics

Browne, C. A., & Lucki, I. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.04.009 · Cited by 97 · see citing works

Genetically Determined Measures of Striatal D2 Signaling Predict Prefrontal Activity during Working Memory Performance

Bertolino, A., Taurisano, P., Pisciotta, N. M., Blasi, G., Fazio, L., Romano, R., Gelao, B., Bianco, L. L., Lozupone, M., Giorgio, A. D., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009348 · Cited by 97 · see citing works

A mu opioid receptor gene polymorphism (A118G) and naltrexone treatment response in adherent Korean alcohol-dependent patients

Kim, S., Kim, C.-M., Choi, S., Jae, Y.-M., Lee, H.-G., Son, B., Kim, J., Choi, Y.-S., Kim, H.-O., Kim, S., et al. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1330-5 · Cited by 90 · see citing works

Ethnicity interacts with the OPRM1 gene in experimental pain sensitivity

Hastie, B. A., Riley, J. L., Kaplan, L., Herrera, D. G., Campbell, C. M., Virtusio, K., Mogil, J. S., Wallace, M. R., & Fillingim, R. B. (2012) · Pain · doi:10.1016/j.pain.2012.03.022 · Cited by 90 · see citing works

Genetic Mutations that Prevent Pain: Implications for Future Pain Medication

Oertel, B. G., & Lötsch, J. (2008) · Pharmacogenomics · doi:10.2217/14622416.9.2.179 · Cited by 90 · see citing works

Association of dopamine and opioid receptor genetic polymorphisms with response to methadone maintenance treatment

Crettol, S., Besson, J., Croquette-Krokar, M., Hämmig, R., Gothuey, I., Monnat, M., Déglon, J., Preisig, M., & Eap, C. B. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.07.009 · Cited by 89 · see citing works

Association ofOPRD1polymorphisms with heroin dependence in a large case-control series

Nelson, E. C., Lynskey, M. T., Heath, A. C., Wray, N. R., Arpana Agrawal, A., Shand, F., Henders, A. K., Wallace, L. M., Todorov, A. A., Schrage, A. J., et al. (2012) · Addiction Biology · doi:10.1111/j.1369-1600.2012.00445.x · Cited by 89 · see citing works

Pain-related effects of trait anger expression: Neural substrates and the role of endogenous opioid mechanisms

Bruehl, S., Burns, J. W., Chung, O. Y., & Chont, M. (2009) · Neuroscience &amp; Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.12.003 · Cited by 88 · see citing works

Common single nucleotide variants underlying drug addiction: more than a decade of research

Bühler, K., Giné, E., Echeverry‐Alzate, V., Calleja‐Conde, J., de Fonseca, F. R., & López‐Moreno, J. A. (2015) · Addiction Biology · doi:10.1111/adb.12204 · Cited by 88 · see citing works

Endogenous Opioid Blockade and Impulsive Responding in Alcoholics and Healthy Controls

Mitchell, J., Tavares, V. C., Fields, H. L., D’Esposito, M., & Boettiger, C. A. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301226 · Cited by 88 · see citing works

Interacting Effects of Naltrexone and OPRM1 and DAT1 Variation on the Neural Response to Alcohol Cues

Schacht, J. P., Anton, R. F., Voronin, K. E., Randall, P. K., Li, X., Henderson, S., & Myrick, H. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.195 · Cited by 86 · see citing works

Addiction pharmacogenetics

Patriquin, M. A., Bauer, I. E., Soares, J. C., Graham, D. P., & Nielsen, D. A. (2015) · Psychiatric Genetics · doi:10.1097/ypg.0000000000000095 · Cited by 86 · see citing works

Genetics and Smoking Cessation

Lerman, C. E., Schnoll, R. A., & Munafo, M. R. (2007) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2007.09.006 · Cited by 84 · see citing works

Allelic expression of serotonin transporter (SERT) mRNA in human pons: lack of correlation with the polymorphism SERTLPR

Lim, J.-E., Papp, A. C., Pinsonneault, J. K., Sadée, W., & Saffen, D. W. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001797 · Cited by 86 · see citing works

Gene Variant Suggests Link To Addiction Vulnerability

Milne, D. (2005) · Psychiatric News · doi:10.1176/pn.40.21.0028

Consequences of the 118A>G polymorphism in the OPRM1 gene: translation from bench to bedside?

Mura, E., Govoni, S. M., Racchi, M., Carossa, V., Ranzani, G. N., Allegri, M., & van Schaik, R. H. N. (2013) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 7 · see citing works

Single‐nucleotide polymorphism (A118G) in exon 1 ofOPRM1gene causes alteration in downstream signaling by mu‐opioid receptor and may contribute to the genetic risk for addiction

Deb, I., Chakraborty, J., Gangopadhyay, P. K., Choudhury, S. R., & Das, S. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06472.x · Cited by 104 · see citing works

OPRM1 SNP (A118G): Involvement in disease development, treatment response, and animal models

Mague, S. D., & Blendy, J. A. (2010) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2009.12.016 · Cited by 136 · see citing works

Synaptic Regulation by OPRM1 Variants in Reward Neurocircuitry

Popova, D., Desai, N., Blendy, J. A., & Pang, Z. P. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2317-18.2019 · Cited by 22 · see citing works