Human Catechol- O -Methyltransferase Haplotypes Modulate Protein Expression by Altering mRNA Secondary Structure

Nackley, A. G.; Shabalina, S. A.; Tchivileva, I. E.; Satterfield, K.; Korchynskyi, O.; Makarov, S. S.; Maixner, W.; Diatchenko, L.

doi:10.1126/science.1131262

Human Catechol- O -Methyltransferase Haplotypes Modulate Protein Expression by Altering mRNA Secondary Structure

Catechol-O-methyltransferase (COMT) is a key regulator of pain perception, cognitive function, and affective mood. Three common haplotypes of the human COMT gene, divergent in two synonymous and one nonsynonymous position, code for differences in COMT enzymatic activity and are associated with pa…