The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Tracing the Source of Campylobacteriosis
Open accessAbstract
Campylobacter jejuni is the leading cause of bacterial gastro-enteritis in the developed world. It is thought to infect 2-3 million people a year in the US alone, at a cost to the economy in excess of US $4 billion. C. jejuni is a widespread zoonotic pathogen that is carried by animals farmed for meat and poultry. A connection with contaminated food is recognized, but C. jejuni is also commonly found in wild animals and water sources. Phylogenetic studies have suggested that genotypes pathogenic to humans bear greatest resemblance to non-livestock isolates. Moreover, seasonal variation in campylobacteriosis bears the hallmarks of water-borne disease, and certain outbreaks have been attributed to contamination of drinking water. As a result, the relative importance of these reservoirs to human disease is controversial. We use multilocus sequence typing to genotype 1,231 cases of C. jejuni isolated from patients in Lancashire, England. By modeling the DNA sequence evolution and zoonotic transmission of C. jejuni between host species and the environment, we assign human cases probabilistically to source populations. Our novel population genetics approach reveals that the vast majority (97%) of sporadic disease can be attributed to animals farmed for meat and poultry. Chicken and cattle are the principal sources of C. jejuni pathogenic to humans, whereas wild animal and environmental sources are responsible for just 3% of disease. Our results imply that the primary transmission route is through the food chain, and suggest that incidence could be dramatically reduced by enhanced on-farm biosecurity or preventing food-borne transmission.
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Cites
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THE NUMBER OF ALLELES THAT CAN BE MAINTAINED IN A FINITE POPULATION
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Bayesian Analysis of Genetic Differentiation Between Populations
Corander, J., Waldmann, P., & Sillanpää, M. J. (2003) · Genetics · doi:10.1093/genetics/163.1.367 · Cited by 860
Multilocus Sequence Typing System for Campylobacter jejuni
Dingle, K. E., Colles, F. M., Wareing, D. R. A., Ure, R., Fox, A. J., Bolton, F. E., Bootsma, H. J., Willems, R. J. L., Urwin, R., & Maiden, M. C. J. (2001) · Journal of Clinical Microbiology · doi:10.1128/jcm.39.1.14-23.2001 · Cited by 852
Self-citationCampylobacters as zoonotic pathogens: A food production perspective
Humphrey, T., O'Brien, S., & Madsen, M. (2007) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2007.01.006 · Cited by 733
Consequences of Recombination on Traditional Phylogenetic Analysis
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Friedman, C. R., Hoekstra, R. M., Samuel, M., Marcus, R., Bender, J., Shiferaw, B., Reddy, S., Desai Ahuja, S., Helfrick, D. L., Hardnett, F., et al. (2004) · Clinical Infectious Diseases · doi:10.1086/381598 · Cited by 536
Disease Risks from Foods, England and Wales, 1996–2000
Adak, G. K., Meakins, S. M., Yip, H., Lopman, B. A., & O'Brien, S. J. (2005) · Emerging Infectious Diseases · doi:10.3201/eid1103.040191 · Cited by 322
Gillespie, I. A., O’Brien, S. J., Frost, J. A., Adak, G. K., Horby, P., Swan, A. V., Painter, M. J., Neal, K. R., & Collaborators, T. C. S. S. S. (2002) · Emerging Infectious Diseases · doi:10.3201/eid0809.010817 · Cited by 303
Cited by
Hald, T., Aspinall, W., Devleesschauwer, B., Cooke, R., Corrigan, T., Havelaar, A. H., Gibb, H. J., Torgerson, P. R., Kirk, M. D., Angulo, F. J., et al. (2016) · PLOS ONE · doi:10.1371/journal.pone.0145839 · Cited by 242
DOMINGUES, A. R., PIRES, S. M., HALASA, T., & HALD, T. (2012) · Epidemiology and Infection · doi:10.1017/s0950268811002676 · Cited by 207
Islam, M. R., Martinez-Soto, C. E., Lin, J. T., Khursigara, C. M., Barbut, S., & Anany, H. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1984200 · Cited by 47
Metadata
- Authors
- Wilson, D. J., Gabriel, E., Leatherbarrow, A. J. H., Cheesbrough, J., Gee, S., Bolton, E., Fox, A., Fearnhead, P., Hart, C. A., & Diggle, P. J.
- Venue
- PLoS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2008-09-26
- Volume
- 4
- Issue
- 9
- Pages
- e1000203
- ISSN
- 1553-7390 (ISSN-L)
- 1553-7404
- OpenAlex
- W2089058761
- Cited by
- 448
- References
- 30
- FWCI
- 51.41
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Tracing the Source of Campylobacteriosis. https://app.cochat.ai/papers/10.1371/journal.pgen.1000203
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- Wilson, D. J., Gabriel, E., Leatherbarrow, A. J. H., Cheesbrough, J., Gee, S., Bolton, E., Fox, A., Fearnhead, P., Hart, C. A., & Diggle, P. J. (2008). Tracing the Source of Campylobacteriosis. PLoS Genetics. https://doi.org/10.1371/journal.pgen.1000203
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
