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Population-Based Resequencing of Experimentally Evolved Populations Reveals the Genetic Basis of Body Size Variation in Drosophila melanogaster

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Turner, Thomas L., Stewart, Andrew D., Fields, Andrew T., Rice, William R., Tarone, Aaron M.·2011·PLoS Genetics

DOI 10.1371/journal.pgen.1001336PMC PMC3060078

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Abstract

Body size is a classic quantitative trait with evolutionarily significant variation within many species. Locating the alleles responsible for this variation would help understand the maintenance of variation in body size in particular, as well as quantitative traits in general. However, successful genome-wide association of genotype and phenotype may require very large sample sizes if alleles have low population frequencies or modest effects. As a complementary approach, we propose that population-based resequencing of experimentally evolved populations allows for considerable power to map functional variation. Here, we use this technique to investigate the genetic basis of natural variation in body size in Drosophila melanogaster. Significant differentiation of hundreds of loci in replicate selection populations supports the hypothesis that the genetic basis of body size variation is very polygenic in D. melanogaster. Significantly differentiated variants are limited to single genes at some loci, allowing precise hypotheses to be formed regarding causal polymorphisms, while other significant regions are large and contain many genes. By using significantly associated polymorphisms as a priori candidates in follow-up studies, these data are expected to provide considerable power to determine the genetic basis of natural variation in body size.

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Authors: Turner, T. L., Stewart, A. D., Fields, A. T., Rice, W. R., & Tarone, A. M.
Affiliations: University of California, Santa Barbara (US)
Texas A&M University (US)
Corresponding author: Turner, Thomas L.
ORCID: Turner, Thomas L.
Stewart, Andrew D.
Fields, Andrew T.
Tarone, Aaron M.
Venue: PLoS Genetics
Publisher: Public Library of Science (PLoS)
Published: 2011-03-17
Volume: 7
Issue: 3
Pages: e1001336
ISSN: 1553-7390 (ISSN-L)
1553-7404
DOI: 10.1371/journal.pgen.1001336
PMC: PMC3060078
OpenAlex: W2036620956
Cited by: 297
References: 53
Citations by year: 2026: 19 · 2025: 11 · 2024: 22 · 2023: 15 · 2022: 16 · 2021: 21 · 2020: 22 · 2019: 20 · 2018: 16 · 2017: 17 · 2016: 23 · 2015: 29 · 2014: 21 · 2013: 21 · 2012: 20
FWCI: 12.97
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: PLoS Genetics (publishedVersion, cc-by)
PubMed Central (publishedVersion, other-oa)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Figshare (submittedVersion, cc-by)
OakTrust (Texas A&M University Libraries) (submittedVersion)
Funders: Texas AgriLife Research
National Institutes of Health
University of California, Santa Barbara
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD057974)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
Keywords: body size variation, Drosophila melanogaster, experimental evolution, quantitative trait loci, polygenic inheritance, natural genetic variation, selection signatures, genome-wide association study
MeSH terms: Alleles, Animals, Chromosome Mapping, Drosophila melanogaster, Female, Gene Frequency, Genetics, Population, Genotype, Male, Phenotype, Polymorphism, Genetic, Sequence Analysis, DNA, Evolution, Molecular, Body Size, Genome-Wide Association Study

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Population-Based Resequencing of Experimentally Evolved Populations Reveals the Genetic Basis of Body Size Variation in Drosophila melanogaster

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