The DOI matches its Crossref record; 35 of the 36 references it cites were found in a registry or an index.
Large-Scale Gene-Centric Analysis Identifies Novel Variants for Coronary Artery Disease
Open accessAbstract
Coronary artery disease (CAD) has a significant genetic contribution that is incompletely characterized. To complement genome-wide association (GWA) studies, we conducted a large and systematic candidate gene study of CAD susceptibility, including analysis of many uncommon and functional variants. We examined 49,094 genetic variants in ∼2,100 genes of cardiovascular relevance, using a customised gene array in 15,596 CAD cases and 34,992 controls (11,202 cases and 30,733 controls of European descent; 4,394 cases and 4,259 controls of South Asian origin). We attempted to replicate putative novel associations in an additional 17,121 CAD cases and 40,473 controls. Potential mechanisms through which the novel variants could affect CAD risk were explored through association tests with vascular risk factors and gene expression. We confirmed associations of several previously known CAD susceptibility loci (eg, 9p21.3:p<10(-33); LPA:p<10(-19); 1p13.3:p<10(-17)) as well as three recently discovered loci (COL4A1/COL4A2, ZC3HC1, CYP17A1:p<5×10(-7)). However, we found essentially null results for most previously suggested CAD candidate genes. In our replication study of 24 promising common variants, we identified novel associations of variants in or near LIPA, IL5, TRIB1, and ABCG5/ABCG8, with per-allele odds ratios for CAD risk with each of the novel variants ranging from 1.06-1.09. Associations with variants at LIPA, TRIB1, and ABCG5/ABCG8 were supported by gene expression data or effects on lipid levels. Apart from the previously reported variants in LPA, none of the other ∼4,500 low frequency and functional variants showed a strong effect. Associations in South Asians did not differ appreciably from those in Europeans, except for 9p21.3 (per-allele odds ratio: 1.14 versus 1.27 respectively; P for heterogeneity = 0.003). This large-scale gene-centric analysis has identified several novel genes for CAD that relate to diverse biochemical and cellular functions and clarified the literature with regard to many previously suggested genes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Since 2007, genomewide association analyses have identified more than 50 independent loci associated with the risk of coronary artery disease.7–15”
From Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease (2016) · cites this paper as [13]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
PLINK: a tool set for whole-genome association and population-based linkage analyses.
Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M. A. R., Bender, D., Maller, J., Sklar, P., de Bakker, P. I. W., Daly, M. J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/519795 · Cited by 34,089
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442
Self-citationInflammation, Atherosclerosis, and Coronary Artery Disease
Hansson, G. K. (2005) · New England Journal of Medicine · doi:10.1056/nejmra043430 · Cited by 8,773
Hindorff, L. A., Sethupathy, P., Junkins, H. A., Ramos, E. M., Mehta, J. P., Collins, F. S., & Manolio, T. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903103106 · Cited by 4,013
Biological, clinical and population relevance of 95 loci for blood lipids
Teslovich, T. M., Musunuru, K., Smith, A. V., Edmondson, A. C., Stylianou, I. M., Koseki, M., Pirruccello, J. P., Ripatti, S., Chasman, D. I., Willer, C. J., et al. (2010) · Nature · doi:10.1038/nature09270 · Cited by 3,487
The Wellcome Trust Case Control Consortium, U.K.
Mossman, K. (2008) · Scientific American · doi:10.1038/scientificamerican0108-42a · Cited by 2,714
Genomewide Association Analysis of Coronary Artery Disease
Samani, N. J., Erdmann, J., Hall, A. S., Hengstenberg, C., Mangino, M., Mayer, B., Dixon, R. J., Meitinger, T., Braund, P., Wichmann, H.-E., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa072366 · Cited by 2,044
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
Cardiogenics, Schunkert, H., the CARDIoGRAM Consortium, König, I. R., Kathiresan, S., Reilly, M. P., Assimes, T. L., Holm, H., Preuss, M., Stewart, A. F. R., et al. (2011) · Nature Genetics · doi:10.1038/ng.784 · Cited by 1,866
Wellcome Trust Case Control Consortium, Zeggini, E., Scott, L. J., Saxena, R., Voight, B. F., Marchini, J. L., Hu, T., de Bakker, P. I., Abecasis, G. R., Almgren, P., et al. (2008) · Nature Genetics · doi:10.1038/ng.120 · Cited by 1,864
Genetic Variants Associated with Lp(a) Lipoprotein Level and Coronary Disease
Clarke, R., Peden, J. F., Hopewell, J. C., Kyriakou, T., Goel, A., Heath, S. C., Parish, S., Barlera, S., Franzosi, M. G., Rust, S., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0902604 · Cited by 1,671
Flagged first, then by citations
1 of the 36 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 101–200 of 237
Guo, Y., Wang, F., Li, L., Gao, H., Arckacki, S., Wang, I. Z., Barnard, J., Ellis, S. G., Hubbard, C. A., Topol, E. J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-05381-2 · Cited by 24
Puimedon, M. S., Mergia, E., Al‐Hasani, J., Aherrahrou, R., Stoelting, S., Kremer, F. J. B., Freyer, J., Koesling, D., Erdmann, J., Schunkert, H., et al. (2016) · American Journal Of Pathology · doi:10.1016/j.ajpath.2016.04.010 · Cited by 26
Lipoprotein(a) as a therapeutic target in cardiovascular disease
Koschinsky, M. L., & Boffa, M. B. (2014) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2014.920326 · Cited by 22
Dai, C.-F., Xie, X., Yang, Y., Li, X., Zheng, Y., Fu, Z.-Y., Liu, F., Chen, B., Gai, M., & Ma, Y. (2015) · Lipids in Health and Disease · doi:10.1186/s12944-015-0007-4 · Cited by 21
Genetic Regulatory Networks of Apolipoproteins and Associated Medical Risks
Basavaraju, P., Balasubramani, R., Kathiresan, D. S., Devaraj, I., Babu, K., Vasanthakumar, A., & Moorthi, P. V. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.788852 · Cited by 22
Guay, S., Brisson, D., Mathieu, P., Bossé, Y., Gaudet, D., & Bouchard, L. (2015) · Epigenomics · doi:10.2217/epi.14.64 · Cited by 21
Potential risks associated with increased plasma plant-sterol levels
Vergès, B. L., & Fumeron, F. (2014) · Diabetes & Metabolism · doi:10.1016/j.diabet.2014.11.003 · Cited by 20
Yiannakouris, N., Katsoulis, M., Dilis, V., Parnell, L. D., Trichopoulos, D., Ordovás, J. M., & Trichopoulou, A. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.02.033 · Cited by 19
Etiologic Puzzle of Coronary Artery Disease: How Important Is Genetic Component?
Butnariu, L. I., Florea, L., Bădescu, M. C., Țarcă, E., Costache, I. I., & Gorduza, E. V. (2022) · Life · doi:10.3390/life12060865 · Cited by 23
Lipoprotein(a) and Arterial Stiffness Parameters
Sorokin, A. V., & Kotani, K. (2015) · Pulse · doi:10.1159/000438733 · Cited by 19
Genome-Wide Association Studies of Cardiovascular Disease in European and Non-European Populations
McPherson, R. (2014) · Current Genetic Medicine Reports · doi:10.1007/s40142-014-0033-y · Cited by 20
Zimetti, F., Favari, E., Cagliero, P., Adorni, M. P., Ronda, N., Bonardi, R., Gomaraschi, M., Calabresi, L., Bernini, F., & Guardamagna, O. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.08.007 · Cited by 20
Coronary Artery Disease: Why We should Consider the Y Chromosome
Molina, E., Clarence, E. M., Ahmady, F., Chew, G. S., & Charchar, F. J. (2016) · Heart Lung and Circulation · doi:10.1016/j.hlc.2015.12.100 · Cited by 21
Grammer, T. B., Hoffmann, M. M., Scharnagl, H., Kleber, M. E., Silbernagel, G., Pilz, S., Tomaschitz, A., Lerchbaum, E., Siekmeier, R., & März, W. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht001 · Cited by 20
Yan, T.-T., Yin, R., Li, Q., Huang, P., Zeng, X., Huang, K., Aung, L. H. H., Wu, D., Liu, C., & Pan, S. (2011) · Lipids in Health and Disease · doi:10.1186/1476-511x-10-248 · Cited by 19
Non-canonical lysosomal lipolysis drives mobilization of adipose tissue energy stores with fasting
Kumar, G. N., Wang, R., Sharma, A. X., David, N. L., Amorim, T., Sinden, D. S., Doshi, N. K., Wabitsch, M., Gingras, S., Ejaz, A., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-56613-3 · Cited by 21
Saad, M., El-Menyar, A. A., Kunji, K. B., Ullah, E., Suwaidi, J. M. S. A., & Kullo, I. J. (2022) · Circulation Genomic and Precision Medicine · doi:10.1161/circgen.122.003712 · Cited by 16
Polygenic Risk Score Associates With Atherosclerotic Plaque Characteristics at Autopsy
Cornelissen, A., Gadhoke, N. V., Ryan, K. A., Hodonsky, C. J., Mitchell, R., Bihlmeyer, N. A., Duong, T., Chen, Z., Dikongue, A., Sakamoto, A., et al. (2023) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.123.319818 · Cited by 16
Lusk, C. M., Dyson, G. E., Clark, A. G., Ballantyne, C. M., Frikke‐Schmidt, R., Tybjærg‐Hansen, A., Boerwinkle, E., & Sing, C. F. (2014) · Human Genetics · doi:10.1007/s00439-014-1451-3 · Cited by 17
Pujol‐Moix, N., Martínez-Pérez, Á., Sabater‐Lleal, M., Llobet, D., Vilalta, N., Hamsten, A., Souto, J. C., & Soria, J. M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133221 · Cited by 17
Investigating Coronary Artery Disease methylome through targeted bisulfite sequencing
Ghose, S., Ghosh, S., Tanwar, V. S., Tolani, P., Kutum, R., Sharma, A., Bhardwaj, N., Vellarikkal, S. K., Verma, A., Jayarajan, R., et al. (2019) · Gene · doi:10.1016/j.gene.2019.144107 · Cited by 18
Liu, Y.-T., Tantoh, D. M., Wang, L., Nfor, O. N., Hsu, S., Ho, C., Lung, C.-C., Chang, H., & Liaw, Y. (2020) · Nutrients · doi:10.3390/nu12051301 · Cited by 17
Ichihara, S., Yamamoto, K., Asano, H., Nakatochi, M., Sukegawa, M., Ichihara, G., Izawa, H., Hirashiki, A., Takatsu, F., Umeda, H., et al. (2013) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.111.000027 · Cited by 17
Szpakowicz, A., Pepiński, W., Waszkiewicz, E., Maciorkowska, D., Skawrońska, M., Niemcunowicz‐Janica, A., Milewski, R. J., Dobrzycki, S., Musial, W. J., & Kamiński, K. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095513 · Cited by 17
RetractedChung, H., Dobson, A. J., Hayashi, K., Hardy, R., Kuh, D. J., Anderson, D. J., van der Schouw, Y. T., Greenwood, D. C., Cade, J. E., Demakakos, P., et al. (2023) · Diabetes Care · doi:10.2337/dc23-1209 · Cited by 16
Genome-Wide Association Studies and Risk Scores for Coronary Artery Disease: Sex Biases
Byars, S., & Inouye, M. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-77932-4_38 · Cited by 16
LIPA, a risk locus for coronary artery disease: decoding the variant-to-function relationship
Li, F., Flynn, E. D., Ha, P., Zebak, M., Cheng, H.-X., Xue, C.-Y., Shi, J., Wu, X., Wang, Z., Meng, Y., et al. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehaf581 · Cited by 9
McLeod, O., Silveira, A. M. V., Valdés‐Márquez, E., Björkbacka, H., Almgren, P., Gertow, K., Gådin, J. R., Bäcklund, A., Sennblad, B., Baldassarre, D., et al. (2016) · Cytokine · doi:10.1016/j.cyto.2016.01.007 · Cited by 15
No large-effect low-frequency coding variation found for myocardial infarction
Holmen, O. L., Zhang, H., Zhou, W., Schmidt, E. M., Hovelson, D. H., Langhammer, A., Løchen, M., Ganesh, S. K., Mathiesen, E. B., VATTEN, L. J., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu175 · Cited by 14
Šilarova, B., Lucas, J., Butterworth, A. S., Angelantonio, E. D., Girling, C., Lawrence, K., Mackintosh, S., Moore, C. S., Payne, R., Sharp, S. J., et al. (2015) · BMC Public Health · doi:10.1186/s12889-015-2192-5 · Cited by 15
LIPA Variants in Genome-Wide Association Studies of Coronary Artery Diseases
Zhang, H., & Reilly, M. P. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.309344 · Cited by 14
Celeski, M., Segreti, A., Crisci, F., Cricco, R., Piscione, M., Gioia, G. D., Nusca, A., FOSSATI, C., Pigozzi, F., Ussia, G. P., et al. (2024) · Biomolecules · doi:10.3390/biom14121630 · Cited by 13
Meta-analyses of four eosinophil related gene variants in coronary heart disease
Lian, J., Huang, Y., Huang, R. S., Xu, L., Le, Y., Yang, X., Xu, W., Huang, X., Ye, M., Zhou, J., et al. (2013) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-012-0862-z · Cited by 13
Huang, K., Yin, R., Zeng, X., Huang, P., Lin, Q.-Z., Wu, J., Guo, T., Wang, W., Yang, D.-Z., & Lin, W. (2013) · International Journal of Medical Sciences · doi:10.7150/ijms.6421 · Cited by 14
A Genetic Risk Score is Associated with Statin-Induced Low-Density Lipoprotein Cholesterol Lowering
Leusink, M., der Zee, A. H. M., Ding, B., Drenos, F., van Iperen, E. P. A., Warren, H. R., Caulfield, M. J., Cupples, L. A., Cushman, M., Hingorani, A. D., et al. (2016) · Pharmacogenomics · doi:10.2217/pgs.16.8 · Cited by 13
Role of interleukins in the pathogenesis of coronary heart disease: A literature review
Rafaqat, S., Azam, A., Hafeez, R., Faseeh, H., Tariq, M., Asif, M. K., Arshad, A., & Noshair, I. (2025) · World Journal of Cardiology · doi:10.4330/wjc.v17.i3.103947 · Cited by 12
Identifying functional modules for coronary artery disease by a prior knowledge-based approach
Li, H., Zuo, X., Ouyang, P., Lin, M., Zhao, Z., Liang, Y., Zhong, S., & Rao, S. (2014) · Gene · doi:10.1016/j.gene.2013.12.049 · Cited by 12
Genetics and coronary artery disease: present and future.
Bampali, K., Mouzarou, A., Lamnisou, K., & Babalis, D. (2014) · PubMed · Cited by 12
Laursen, I. H., Banasik, K., Haue, A. D., Petersen, O., Holm, P. C., Westergaard, D., Bundgaard, H., Brunak, S., Frikke‐Schmidt, R., Hólm, H., et al. (2021) · BMJ Open · doi:10.1136/bmjopen-2021-049709 · Cited by 12
Szpakowicz, A., Kiliszek, M., Pepiński, W., Waszkiewicz, E., Franaszczyk, M., Skawrońska, M., Płoski, R., Niemcunowicz‐Janica, A., Dobrzycki, S., Opolski, G., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104635 · Cited by 12
Lysosomal acid lipase deficiency: a form of non-obese fatty liver disease (NOFLD)
A‐Kader, H. H. (2017) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2017.1343144 · Cited by 12
Myocardial ischemia and its complications
Fishbein, G. A., Fishbein, M. C., Wang, J., & Buja, L. M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-822224-9.00022-0 · Cited by 12
c.*84G>A Mutation in CETP Is Associated with Coronary Artery Disease in South Indians
Ganesan, M., Nizamuddin, S., Katkam, S. K., Kumaraswami, K., Hosad, U. K., Lobo, L. L., Kutala, V. K., & Kumarasamy Thangaraj, K. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164151 · Cited by 10
Niemiec, P., Górczyńska-Kosiorz, S. B., Iwanicki, T., Krauze, J., Trautsolt, W., Grzeszczak, W., Bochenek, A. A., & Żak, I. (2012) · Genetic Testing and Molecular Biomarkers · doi:10.1089/gtmb.2012.0046 · Cited by 12
TWIST1 drives endothelial-to-mesenchymal-transition to stabilize atherosclerotic plaques
Ayllón, B. T., Diagbouga, M. R., Das, A., Tian, S., Edsfeldt, A., Kalucka, J. M., Serbanovic‐Canic, J., Chambers, E. V., Sun, J., Gialeli, C., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-69808-z · Cited by 10
Svensson, T., Kitliński, M., Engström, G., & Melander, O. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176029 · Cited by 13
Adipocyte-specific tribbles pseudokinase 1 regulates plasma adiponectin and plasma lipids in mice
Ha, E. E., Quartuccia, G. I., Ling, R., Xue, C., Karikari, R. A., Hernández‐Ono, A., Hu, K. Y., Matias, C. V., Imam, R., Cui, J. G., et al. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101412 · Cited by 11
Clinical validation of genetic markers for improved risk estimation
Kessler, T., & Schunkert, H. (2012) · European Journal of Preventive Cardiology · doi:10.1177/2047487312448993 · Cited by 11
Genetics of the acute coronary syndrome
Franchini, M. (2016) · Annals of Translational Medicine · doi:10.21037/atm.2016.02.12 · Cited by 10
Shared Genetic Aetiology of Coronary Artery Disease and Atherosclerotic Stroke—2015
Kessler, T., Erdmann, J., Dichgans, M., & Schunkert, H. (2015) · Current Atherosclerosis Reports · doi:10.1007/s11883-015-0498-5 · Cited by 9
Toward Individualized Cholesterol-Lowering Treatment in End-Stage Renal Disease
Silbernagel, G., Baumgärtner, I., Wanner, C., & März, W. (2014) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2013.11.001 · Cited by 10
Ikeoka, T., Hayashida, N., Nakazato, M., Sekita, T., Murata-Mori, F., Ando, T., Abiru, N., Yamasaki, H., Kudo, T., Maeda, T., et al. (2014) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.233.149 · Cited by 9
The Role of Genetic Risk Factors in Coronary Artery Disease
Dandona, S., & Roberts, R. (2014) · Current Cardiology Reports · doi:10.1007/s11886-014-0479-2 · Cited by 9
Li, Y., Li, L., Bi, L., Xu, X., Cheng, W., Yu, B., & Zhang, Y. (2018) · Gene · doi:10.1016/j.gene.2018.07.016 · Cited by 9
Szpakowicz, A., Pepiński, W., Waszkiewicz, E., Maciorkowska, D., Skawrońska, M., Niemcunowicz‐Janica, A., Milewski, R. J., Dobrzycki, S., Musial, W. J., & Kamiński, K. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072333 · Cited by 9
RetractedKhetarpal, S. A., & Rader, D. J. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.06.007 · Cited by 9
ABCG5/8 variants are associated with susceptibility to coronary heart disease
Wu, G., Li, G.-B., Yao, M., ZHANG, D.-Q., DAI, B., Ju, C., & Han, M. Z. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2098 · Cited by 9
Frånberg, M., Gertow, K., Hamsten, A., Lagergren, J., & Sennblad, B. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005502 · Cited by 9
Zhang, Z., Hsieh, B., Poe, A. R., Anderson, J., Ocorr, K. A., Gibson, G. C., & Bodmer, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062909 · Cited by 8
Musameh, M. D., Wang, W. Y. S., Nelson, C. P., Lluís-Ganella, C., Dębiec, R., Subirana, I., Elosúa, R., Balmforth, A. J., Ball, S. G., Hall, A. S., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117684 · Cited by 8
Experimental Biology for the Identification of Causal Pathways in Atherosclerosis
Guo, Y., Garcia-Barrio, M. T., Wang, L., & Chen, Y. (2016) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-016-6644-7 · Cited by 8
Nagai, K., Chung, H., Hayashi, K., Dobson, A. J., Ideno, Y., Sandin, S., van der Schouw, Y. T., Hardy, R., Anderson, D. J., Demakakos, P., et al. (2025) · Diabetes Care · doi:10.2337/dc25-1478 · Cited by 10
Foulkes, A. S., Matthews, G. J., Das, U., Ferguson, J. F., Lin, R., & Reilly, M. P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054812 · Cited by 8
Positive correlation between variants of lipid metabolism-related genes and coronary heart disease
Zhang, L. N., Liu, P., Zhou, J., Huang, R. S., YUAN, F., Fei, L.-J., Huang, Y., Xu, L., HAO, L.-M., QIU, X.-J., et al. (2013) · Molecular Medicine Reports · doi:10.3892/mmr.2013.1454 · Cited by 7
Gao, M., Tang, H., Zheng, X., Zhou, F., & Lu, W. (2015) · Europe PMC (PubMed Central) · Cited by 7
Beyond Genome-Wide Association Studies
Welch, C. L. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.232694 · Cited by 7
Xie, L., Yan, H., Shi, L., Kong, Y., Huang, M., Li, J., Li, J., Zheng, J., Zhao, Y., & Zhao, S. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.02.053 · Cited by 7
Experimental Evolution and Heart Function inDrosophila
Shahrestani, P., Burke, M. K., Birse, R. T., Kezos, J. N., Ocorr, K. A., Mueller, L. D., Rose, M. R., & Bodmer, R. (2016) · Physiological and Biochemical Zoology · doi:10.1086/689288 · Cited by 7
Application of Genome-Wide Association Studies in Coronary Artery Disease
Zheng, H., Zeng, Z., Wen, H., Wang, P., Huang, C., Huang, P., Chen, Q., Gong, D., & Qiu, X. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666191105125148 · Cited by 7
Treatment with fibrates is associated with higher LAL activity in dyslipidemic patients
Pavanello, C., Baragetti, A., Branchi, A., Grigore, L., Castelnuovo, S., Giorgio, E., Catapano, A. L., Calabresi, L., & Gomaraschi, M. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104362 · Cited by 7
The genetic basis for survivorship in coronary artery disease
Dungan, J. R., Hauser, E. R., Qin, X., & Kraus, W. E. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00191 · Cited by 7
A Breakthrough in Genetics and its Relevance to Prevention of Coronary Artery Disease in LMIC
Roberts, R. (2017) · Global Heart · doi:10.1016/j.gheart.2017.04.001 · Cited by 6
Neelankavil, J. P., Rau, C. D., & Wang, Y. (2015) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2015.01.031 · Cited by 6
Ancheta, I. B., Battie, C. A., Richard, F. D., Ancheta, C. V., Borja‐Hart, N., Volgman, A. S., & Conley, Y. P. (2014) · Nursing Research and Practice · doi:10.1155/2014/328954 · Cited by 6
Maeda, Y., Sato, N., Naka‐Mieno, M., Mori, S., Arai, T., Tanaka, M., Muramatsu, M., & Sawabe, M. (2016) · Europe PMC (PubMed Central) · doi:10.11909/j.issn.1671-5411.2016.12.003 · Cited by 6
CYP17A1 Polymorphisms Are Linked to the Risk of Coronary Heart Disease in a Case–Control Study
Lu, S., Zhong, J., Zhang, Y., Huang, K., Wu, M., Zhou, Y., Li, Q., Chen, Z., Zhang, S., & Zhou, H. (2019) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000687 · Cited by 6
Effect of Differences in the Microbiome of Cyp17a1-Deficient Mice on Atherosclerotic Background
Künstner, A., Aherrahrou, R., Hirose, M., Bruse, P., Ibrahim, S. M., Busch, H. S., Erdmann, J., & Aherrahrou, Z. (2021) · Cells · doi:10.3390/cells10061292 · Cited by 5
Karimi, Z., Daneshmoghadam, J., Ghaedi, H., Khalili, E., Panahi, G., & Shanaki, M. (2022) · Reports of Biochemistry and Molecular Biology · doi:10.52547/rbmb.10.4.580 · Cited by 5
Genomic Strategies Toward Identification of Novel Therapeutic Targets
Kessler, T., & Schunkert, H. (2020) · Handbook of experimental pharmacology · doi:10.1007/164_2020_360 · Cited by 5
Wei, B., Liu, Y., Li, H., Peng, Y., & Luo, Z. (2023) · Cardiovascular Therapeutics · doi:10.1155/2023/4444708 · Cited by 5
Polygenetic risk for coronary artery disease increases hospitalization burden and mortality
Sjögren, M., Almgren, P., & Melander, O. (2019) · IJC Heart & Vasculature · doi:10.1016/j.ijcha.2019.100391 · Cited by 5
Hou, B., Jia, X., Deng, Z., Liu, X., Liu, H., Yu, H., & Liu, S. (2020) · Human Genomics · doi:10.1186/s40246-020-00286-0 · Cited by 5
Genomic Medicine in the Prevention and Treatment of Atherosclerotic Cardiovascular Disease
Tuteja, S., & Rader, D. J. (2012) · Personalized Medicine · doi:10.2217/pme.12.34 · Cited by 5
Aminbakhsh, A., Théberge, E. T., Burden, E., Adejumo, C. K., Gravely, A., Lehman, A., & Sedlak, T. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1502985 · Cited by 4
Ge, H., Liu, G., Yamawaki, T., Tao, C., Alexander, S. T., Ly, K., Fordstrom, P., Shkumatov, A. A., Li, C.-M., Rajamani, S., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-96936-x · Cited by 4
Integrative Bioinformatics Approaches for Identification of Drug Targets in Hypertension
Hemerich, D., van Setten, J., Tragante, V., & Asselbergs, F. W. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00025 · Cited by 3
Genetic Markers of Myocardial Infarction
Kariž, S. (2012) · Journal of Clinical & Experimental Cardiology · doi:10.4172/2155-9880.s2-007 · Cited by 4
Genetics and Ischemic Heart Disease: Should We Opt for Genetic Testing for Primary Prevention?
Ashraf, T., Ahmed, T., Iqbal, M. U. N., & Nadeem, A. (2023) · Pakistan Heart Journal · doi:10.47144/phj.v56i3.2642 · Cited by 4
Zhang, W., He, J., Liu, M., Huang, M., Chen, Q., Dong, J., Zhang, H., Xie, T., Yuan, J., & Zha, L. (2023) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2023/1700857 · Cited by 3
RetractedGenetics of Atherosclerotic Cardiovascular Disease
Qasim, A., & Reilly, M. P. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-383834-6.00061-6 · Cited by 4
Coronary Artery Disease: Association Study of 5 Loci with Angiographic Indices of Disease Severity
Bogari, N. M., Allam, R. M., Bouazzaoui, A., ElKhateeb, O. E., Porqueddu, M., & Colombo, G. I. (2021) · Disease Markers · doi:10.1155/2021/5522539 · Cited by 3
Григорьева, И. Н., Нотова, Т. Е., Станиславовна, С. Т., & Nepomnyashchikh, D. L. (2024) · Ateroscleroz · doi:10.52727/2078-256x-2024-20-1-6-15 · Cited by 3
Zhang, Z., Su, G., Guo, J., Li, J., Wu, H., Wang, M., & Xie, X. (2015) · IUBMB Life · doi:10.1002/iub.1359 · Cited by 3
Lysosomal Acid Lipase Deficiency
Parham, J. S., & Underberg, J. A. (2020) · Contemporary cardiology · doi:10.1007/978-3-030-56514-5_21 · Cited by 3
Brotherhood of genetics and preventive medication: Figure 1
Schunkert, H. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv153 · Cited by 3
TWIST1 drives endothelial-to-mesenchymal-transition to stabilize atherosclerotic plaquesPreprint
Ayllón, B. T., Diagbouga, M. R., Edsfeldt, A., Kalucka, J. M., Serbanovic‐Canic, J., Chambers, E. V., Sun, J., Gialeli, C., Dunning, M., Li, X., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.19.654847 · Cited by 3
[Research advance of ANRIL on atherosclerosis by regulating cell proliferation and apoptosis].
Fang, J., Pan, Z., & Guo, X. (2020) · PubMed Central · doi:10.3785/j.issn.1008-9292.2020.02.12 · Cited by 2
Genetische Analysen als Basis einer individualisierten Medizin bei koronarer Herzkrankheit
Kessler, T., Kaess, B. M., Bourier, F. J., Erdmann, J., & Schunkert, H. (2014) · Herz · doi:10.1007/s00059-013-4048-z · Cited by 2
Almontashiri, N. A. M., & Hannan, M. A. (2015) · Journal of Taibah University Medical Sciences · doi:10.1016/j.jtumed.2015.01.012 · Cited by 2
Cardiovascular Genetics: Focus on Genetics of Coronary Artery Disease
Marian, A. J. (2015) · Cardiovascular medicine · doi:10.1007/978-1-4471-2828-1_27 · Cited by 2
Metadata
- Authors
- The IBC 50K CAD Consortium
- Affiliations
- QIMR Berghofer Medical Research Institute (AU)
- Corresponding author
- The IBC 50K CAD Consortium
- Venue
- PLoS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-09-22
- Volume
- 7
- Issue
- 9
- Pages
- e1002260
- ISSN
- 1553-7390 (ISSN-L)
- 1553-7404
- PMC
- PMC3178591
- OpenAlex
- W1590005134
- Cited by
- 237
- References
- 36
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 2 · 2023: 7 · 2022: 12 · 2021: 11 · 2020: 7 · 2019: 9 · 2018: 17 · 2017: 18 · 2016: 22 · 2015: 25 · 2014: 36 · 2013: 28 · 2012: 26
- FWCI
- 18.36
- Type
- journal article
- Language
- en
- Update notices
- correction (2012-08-14)
- Open access
- gold
- doi.org
- Locations
- PLoS Genetics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, cc-by)
- Pure Amsterdam UMC (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, other-oa)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- UCL Discovery (University College London) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Leicester Research Archive (University of Leicester) (submittedVersion, other-oa)
- Site cant be reached (submittedVersion, cc-by)
- Research Explorer (The University of Manchester) (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Spiral (Imperial College London) (submittedVersion, other-oa)
- Hirsla (Landspítali University Hospital) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion, other-oa)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Funders
- AstraZeneca
- GlaxoSmithKline
- University of Pennsylvania
- Wellcome Trust (090532)
- National Institute for Health and Care Research (RP-PG-0310-1002, CL-2010-11-001, PG-0310-1002)
- British Heart Foundation (LSHM-CT-2007-037273, RG/09/12/28096, RP-PG-0310-1002, PG-0310-1002, RG/08/014/24067)
- University of Cambridge
- European Commission (201668, LSHM-CT-2007–037273, LSHM-CT 2006–037593, 28,29, LSHM-CT-2004-503485, 57,58)
- Fondation Leducq (05-CVD)
- ZonMw
- Bundesministerium für Bildung und Forschung (01GS0834)
- College ter Beoordeling van Geneesmiddelen
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (2001.064)
- Hjärt-Lungfonden
- Karolinska Institutet
- Knut och Alice Wallenbergs Stiftelse
- Novo Nordisk
- Stockholms Läns Landsting (560283)
- Top Institute Pharma
- KWF Kankerbestrijding
- Center for Translational Molecular Medicine
- Universität Ulm
- Medical Research Council (09/12)
- World Cancer Research Fund
- Agentschap NL
- Münchner Zentrum für Gesundheitswissenschaften
- National Heart, Lung, and Blood Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- coronary artery disease, genetic susceptibility, candidate gene association, novel genetic variants, 9p21.3, LPA, LIPA, TRIB1, ABCG5/ABCG8, CYP17A1, low-frequency variants, functional variants, South Asian populations, European populations, replication, gene expression, serum lipids
- MeSH terms
- Adult, Aged, Alleles, Coronary Artery Disease, Female, Humans, Male, Middle Aged, Risk, Genetic Variation, Case-Control Studies, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, White People, Asian People, Genome-Wide Association Study
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
