Cited by 228Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationGenomics and Chromatin Dynamics

The Transcription Factors Sox10 and Myrf Define an Essential Regulatory Network Module in Differentiating Oligodendrocytes

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Hornig, Julia, Fröb, Franziska, Vogl, Michael R., Hermans-Borgmeyer, Irm, Tamm, Ernst R., Wegner, Michael·2013·PLoS Genetics

Abstract

Myelin is essential for rapid saltatory conduction and is produced by Schwann cells in the peripheral nervous system and oligodendrocytes in the central nervous system. In both cell types the transcription factor Sox10 is an essential component of the myelin-specific regulatory network. Here we identify Myrf as an oligodendrocyte-specific target of Sox10 and map a Sox10 responsive enhancer to an evolutionarily conserved element in intron 1 of the Myrf gene. Once induced, Myrf cooperates with Sox10 to implement the myelination program as evident from the physical interaction between both proteins and the synergistic activation of several myelin-specific genes. This is strongly reminiscent of the situation in Schwann cells where Sox10 first induces and then cooperates with Krox20 during myelination. Our analyses indicate that the regulatory network for myelination in oligodendrocytes is organized along similar general principles as the one in Schwann cells, but is differentially implemented.

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Crossref · 10.1371/journal.pgen.1003907

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  • This transition was accompanied by reduced activity of myelin-associated gene networks and diminished regulon activity of key transcriptional regulators, including MYRF and NKX6-2, which serve as central regulators of myelin gene expression programs.

    “This transition was accompanied by reduced activity of myelin-associated gene networks and diminished regulon activity of key transcriptional regulators, including MYRF and NKX6-2, which serve as central regulators of myelin gene expression programs (53-55) (Fig. 5J).”

    From Molecular and cellular processes disrupted in the early postnatal Down syndrome prefrontal cortex (2026) · cites this paper as [54]

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  1. [10]Qi Y, Cai J, Wu Y, Wu R, Lee J, et al (2001) Control of oligodendrocyte differentiation by the Nkx2.2 homeodomain transcription factor. Development 128: 2723– 2733. 11526078

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Authors
Hornig, J., Fröb, F., Vogl, M. R., Hermans-Borgmeyer, I., Tamm, E. R., & Wegner, M.
Affiliations
  • Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
  • University of Regensburg (DE)
Corresponding author
Wegner, Michael
Venue
PLoS Genetics
Published
2013-10-31
Volume
9
Issue
10
Pages
e1003907
ISSN
  • 1553-7390 (ISSN-L)
  • 1553-7404
OpenAlex
W2083561210
Cited by
228
References
47
Citations by year
2026: 15 · 2025: 22 · 2024: 19 · 2023: 11 · 2022: 24 · 2021: 19 · 2020: 23 · 2019: 24 · 2018: 16 · 2017: 16 · 2016: 17 · 2015: 14 · 2014: 5 · 2013: 3
FWCI
4.83
Type
journal article
Language
en
Open access
Locations
  • PLoS Genetics (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Figshare (submittedVersion, cc-by)
  • OPUS FAU (Kooperativer Bibliotheksverbund Berlin-Brandenburg (KOBV), on behalf of the Universitätsbibliothek Erlangen-Nürnberg) (submittedVersion)
Funders
Deutsche Forschungsgemeinschaft (We1326/11)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords
SOX10, MYRF, oligodendrocyte differentiation, myelination, transcriptional regulatory networks, enhancers, Krox20, Schwann cells, protein-protein interaction, central nervous system myelin
MeSH terms
Animals, Cell Differentiation, Cell Line, Central Nervous System, High Mobility Group Proteins, Humans, Mice, Transgenic, Myelin Sheath, Oligodendroglia, Schwann Cells, Transcription Factors, Gene Expression Regulation, Developmental, Mice, Early Growth Response Protein 2, Gene Regulatory Networks, SOXE Transcription Factors

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