The DOI matches its Crossref record; 64 of the 65 references it cites were found in a registry or an index.
A Susceptible Mouse Model for Zika Virus Infection
Open accessPublished version of a preprint
Abstract
Abstract Zika virus (ZIKV) is a mosquito-borne pathogen which has recently spread beyond Africa and into Pacific and South American regions. Despite first being detected in 1947, very little information is known about the virus and its spread has been associated with increases in Guillain-Barre syndrome and microcephaly. There are currently no known vaccines or antivirals against ZIKV infection. Progress in assessing interventions will require the development of animal models to test efficacies; however, there are only limited reports on in vivo studies. The only susceptible murine models have involved intracerebral inoculations or juvenile animals, which do not replicate natural infection. Our report has studied the effect of ZIKV infection in type-I interferon receptor deficient (A129) mice and the parent strain (129Sv/Ev) after subcutaneous challenge in the lower leg to mimic a mosquito bite. A129 mice developed severe symptoms with viral RNA being detected widespread in the blood, brain, spleen, liver and ovaries. Histological changes were also striking in these animals. 129Sv/Ev mice developed no clinical symptoms or histological changes, despite viral RNA being detectable in the blood, spleen and ovaries, albeit at lower levels to those seen in A129 mice. Our results identify A129 mice as being highly susceptible to ZIKV and thus a suitable small animal model for the testing of vaccines and antivirals which are urgently required. Author summary Since first being recognised in 1947, Zika virus (ZIKV) has mainly been a mild illness with symptoms including a limited fever and rash. In 2007 the virus spread from Africa into French Polynesia and then onwards across Pacific regions and into South America. In these new regions, ZIKV has been associated with more severe clinical conditions including Gullain-Barre syndrome and microcephaly. There are no currently approved antivirals or vaccines available with proven activity against ZIKV, and the World Health Organisation declared the spread of ZIKV as a Public Health Emergency of International Concern. Here, we have used a mouse strain with a deficiency in the type-I interferon receptor (A129) and shown that they are susceptible to ZIKV infection after inoculation that closely resembles the natural route via mosquito bite. Although A129 mice are deficient in the innate interferon response, they retain their adaptive immunity and thus have successfully been used as suitable models for the testing of vaccinations and antivirals. Our study provides details on a suitable model for the testing of future interventions against ZIKV.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“In this regard, small animal models are a better choice for studying ZIKV [10, 21].”
From ICR suckling mouse model of Zika virus infection for disease modeling and drug validation (2018) · cites this paper as [10]
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“AG129 and Irf3/5/7 TKO mice are the immunocompromised mice which were permissive to different strain ZIKV infection and vulnerable to ZIKV-relative pathology and lethality [10, 21, 30, 31].”
From ICR suckling mouse model of Zika virus infection for disease modeling and drug validation (2018) · cites this paper as [10]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Smithburn, K. C. (1952) · The Journal of Immunology · doi:10.4049/jimmunol.69.2.223 · Cited by 3,553
Zika Virus Outbreak on Yap Island, Federated States of Micronesia
Duffy, M. R., Chen, T.-H., Hancock, W. T., Powers, A. M., Kool, J. L., Lanciotti, R. S., Pretrick, M., Marfel, M., Holzbauer, S., Dubray, C. L., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0805715 · Cited by 3,130
Zika Virus Associated with Microcephaly
Mlakar, J., Korva, M., Tul, N., Popović, M., Poljšak-Prijatelj, M., Mraz, J., Kolenc, M., Resman Rus, K., Vesnaver Vipotnik, T., Fabjan Vodušek, V., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1600651 · Cited by 2,884
Zika Virus (I). Isolations and serological specificity
Dick, G. W. A., Kitchen, S. F., & Haddow, A. J. (1952) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(52)90042-4 · Cited by 2,698
Self-citationFunctional Role of Type I and Type II Interferons in Antiviral Defense
Müller, U., Steinhoff, U., Reis, L. F. L., Hemmi, S., Pavlovic, J., Zinkernagel, R. M., & Aguet, M. (1994) · Science · doi:10.1126/science.8009221 · Cited by 2,453
Lanciotti, R. S., Kosoy, O. L., Laven, J. J., Velez, J. O., Lambert, A. J., Johnson, A. J., Stanfield, S. M., & Duffy, M. R. (2008) · Emerging infectious diseases · doi:10.3201/eid1408.080287 · Cited by 2,173
Hughes, R. A., & Cornblath, D. R. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67665-9 · Cited by 1,679
First report of autochthonous transmission of Zika virus in Brazil
Zanluca, C., Melo, V. C. A. D., Mosimann, A. L. P., Santos, G. I. V. D., Santos, C. N. D. D., & Luz, K. (2015) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/0074-02760150192 · Cited by 1,320
Melo, A. S. O., Malinger, G., Ximenes, R., Szejnfeld, P. O., Sampaio, S. A., & de Filippis, A. M. B. (2016) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.15831 · Cited by 1,180
Zika Virus Outbreak, Bahia, Brazil
Campos, G. S., Bandeira, A. C., & Sardi, S. I. (2015) · Emerging infectious diseases · doi:10.3201/eid2110.150847 · Cited by 1,150
Flagged first, then by citations
1 of the 65 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection
Stettler, K., Beltramello, M., Espinosa, D. A., Graham, V., Cassotta, A., Bianchi, S., Zatta, F., Minola, A., Jaconi, S., Mele, F., et al. (2016) · Science · doi:10.1126/science.aaf8505 · Cited by 750
Self-citationKrauer, F., Riesen, M., Revéiz, L., Oladapo, O. T., Martínez-Vega, R. A., Porgo, T. V., Haefliger, A., Broutet, N. J. N., Low, N. N., & WHO Zika Causality Working Group (2017) · PLoS Medicine · doi:10.1371/journal.pmed.1002203 · Cited by 517
A single mutation in the prM protein of Zika virus contributes to fetal microcephaly
Yuan, L., Huang, X., Liu, Z., Zhang, F., Zhu, X., Yu, J.-Y., Ji, X., Xu, Y., Li, G., Li, C., et al. (2017) · Science · doi:10.1126/science.aam7120 · Cited by 482
Vaginal Exposure to Zika Virus during Pregnancy Leads to Fetal Brain Infection
Yockey, L. J., Varela, L., Rakib, T., Khoury-Hanold, W., Fink, S. L., Stutz, B., Szigeti‐Buck, K., van den Pol, A. N., Lindenbach, B. D., Horváth, T. L., et al. (2016) · Cell · doi:10.1016/j.cell.2016.08.004 · Cited by 358
Zika virus — reigniting the TORCH
Coyne, C. B., & Lazear, H. M. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.125 · Cited by 355
Animal Models of Zika Virus Infection, Pathogenesis, and Immunity
Morrison, T. E., & Diamond, M. S. (2017) · Journal of Virology · doi:10.1128/jvi.00009-17 · Cited by 275
Immune Response to Dengue and Zika
Ngono, A. E., & Shresta, S. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042617-053142 · Cited by 269
Sexually acquired Zika virus: a systematic review
Moreira, J. M. B. S., Peixoto, T. M., Siqueira, A. M., & Lamas, C. D. C. (2017) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2016.12.027 · Cited by 265
The clinically approved antiviral drug sofosbuvir inhibits Zika virus replication
Sacramento, C. Q., de Melo, G. R., de Freitas, C. S., da Rocha, N. C., Hoelz, L. V. B., Miranda, M. D., Rodrigues, N. F., Marttorelli, A., Ferreira, A. C., Barbosa-Lima, G., et al. (2017) · Scientific Reports · doi:10.1038/srep40920 · Cited by 249
The Many Faces of the Flavivirus NS5 Protein in Antagonism of Type I Interferon Signaling
Best, S. M. (2016) · Journal of Virology · doi:10.1128/jvi.01970-16 · Cited by 248
Mapping and Role of the CD8 + T Cell Response During Primary Zika Virus Infection in Mice
Ngono, A. E., Vizcarra, E. A., Tang, W. W., Sheets, N., Joo, Y., Kim, K., Gorman, M. J., Diamond, M., & Shresta, S. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2016.12.010 · Cited by 233
Tripathi, S., Balasubramaniam, V. R. M. T., Brown, J. A., Mena, I., Grant, A., Bardina, S. V., Maringer, K., Schwarz, M. C., Maestre, A. M., Sourisseau, M., et al. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006258 · Cited by 230
Viral Innate Immune Evasion and the Pathogenesis of Emerging RNA Virus Infections
Nelemans, T., & Kikkert, M. (2019) · Viruses · doi:10.3390/v11100961 · Cited by 228
Wang, W., Li, G., Wu, D., Luo, Z., Pan, P., Tian, M., Wang, Y., Xiao, F., Li, A., Wu, K., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02645-3 · Cited by 217
Broadly Neutralizing Activity of Zika Virus-Immune Sera Identifies a Single Viral Serotype
Dowd, K. A., DeMaso, C. R., Pelc, R. S., Speer, S. D., Smith, A. R. Y., Goo, L., Platt, D. J., Mascola, J. R., Graham, B. S., Mulligan, M. J., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.07.049 · Cited by 206
Ding, Q., Gaska, J. M., Douam, F., Wei, L., Kim, D., Balev, M., Heller, B. L., & Ploß, A. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1803406115 · Cited by 200
How does Zika virus cause microcephaly?Preprint
Wen, Z., Song, H., & Ming, G. (2017) · Genes & Development · doi:10.1101/gad.298216.117 · Cited by 182
Flavivirus Receptors: Diversity, Identity, and Cell Entry
Lauréti, M., Narayanan, D., Rodriguez‐Andres, J., Fazakerley, J. K., & Kedzierski, Ł. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02180 · Cited by 179
Wen, J., Tang, W. W., Sheets, N., Ellison, J., Sette, A., Kim, K., & Shresta, S. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2017.36 · Cited by 173
Vermillion, M. S., Lei, J., Shabi, Y., Baxter, V. K., Crilly, N. P., McLane, M., Griffin, D. E., Pekosz, A. S., Klein, S. L., & Burd, I. D. (2017) · Nature Communications · doi:10.1038/ncomms14575 · Cited by 164
Julander, J. G., Siddharthan, V., Evans, J., Taylor, R., Tolbert, K., Apuli, C., Stewart, J. P., Collins, P., Gebre, M. S., Neilson, S., et al. (2016) · Antiviral Research · doi:10.1016/j.antiviral.2016.11.003 · Cited by 165
Zika virus induces massive cytoplasmic vacuolization and paraptosis‐like death in infected cells
Monel, B., Compton, A. A., Bruel, T., Amraoui, S., Burlaud‐Gaillard, J., Roy, N., Guivel‐Benhassine, F., Porrot, F., Génin, P., Meertens, L., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201695597 · Cited by 169
Manangeeswaran, M., Ireland, D. D. C., & Verthelyi, D. I. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1006004 · Cited by 159
Zika Virus Strains Potentially Display Different Infectious Profiles in Human Neural Cells
Simonin, Y., Loustalot, F., Desmetz, C., Foulongne, V., Constant, O., Fournier‐Wirth, C., Léon, F., Molès, J., Goubaud, A., Lemaı̂tre, J.-M., et al. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.09.020 · Cited by 157
Nucleoside analogs as a rich source of antiviral agents active against arthropod-borne flaviviruses
Eyer, L., Nencka, R., Clercq, E. D., Seley‐Radtke, K. L., & Růžek, D. (2018) · Antiviral chemistry & chemotherapy · doi:10.1177/2040206618761299 · Cited by 157
A Human Bi-specific Antibody against Zika Virus with High Therapeutic Potential
Wang, J., Bardelli, M., Espinosa, D. A., Pedotti, M., Ng, T., Bianchi, S., Simonelli, L., Lim, E. X. Y., Foglierini, M., Zatta, F., et al. (2017) · Cell · doi:10.1016/j.cell.2017.09.002 · Cited by 148
Self-citationDevelopment of vaccines against Zika virus
Poland, G. A., Kennedy, R. B., Ovsyannikova, I. G., Palácios, R., Ho, P. L., & Kalil, J. E. (2018) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(18)30063-x · Cited by 152
Aubry, F., Jacobs, S., Darmuzey, M., Lequime, S., Delang, L., Fontaine, A., Jupatanakul, N., Miot, E. F., Dabo, S., Manet, C., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21199-z · Cited by 144
Papa, M. P., Meuren, L. M., Coelho, S. V. A., Lucas, C. G. D. O., Mustafá, Y. M., Matassoli, F. L., Silveira, P. P., Frost, P. S., Pezzuto, P., Ribeiro, M. R., et al. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02557 · Cited by 135
Tsetsarkin, K. A., Kenney, H., Chen, R., Liu, G., Manukyan, H., Whitehead, S. S., Laassri, M., Chumakov, K., & Pletnev, A. G. (2016) · mBio · doi:10.1128/mbio.01114-16 · Cited by 131
Pardy, R. D., Rajah, M. M., Condotta, S. A., Taylor, N., Sagan, S. M., & Richer, M. J. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006184 · Cited by 130
Zika virus causes testicular atrophy
Uraki, R., Hwang, J., Jurado, K. A., Householder, S., Yockey, L. J., Hastings, A. K., Homer, R., Iwasaki, A., & Fikrig, E. (2017) · Science Advances · doi:10.1126/sciadv.1602899 · Cited by 134
The Neurobiology of Zika Virus
Li, H., Saucedo-Cuevas, L. P., Shresta, S., & Gleeson, J. G. (2016) · Neuron · doi:10.1016/j.neuron.2016.11.031 · Cited by 135
Aliota, M. T., Bassit, L., Bradrick, S. S., Cox, B. D., García-Blanco, M. A., Gavegnano, C., Friedrich, T. C., Golos, T. G., Griffin, D. E., Haddow, A. D., et al. (2017) · Antiviral Research · doi:10.1016/j.antiviral.2017.06.001 · Cited by 133
Zika virus: An emergent neuropathological agent
White, M. K., Wollebo, H. S., Beckham, J. D., Tyler, K. L., & Khalili, K. (2016) · Annals of Neurology · doi:10.1002/ana.24748 · Cited by 126
Mladinich, M. C., Schwedes, J. F., & Mackow, E. R. (2017) · mBio · doi:10.1128/mbio.00952-17 · Cited by 123
Differential virulence between Asian and African lineages of Zika virus
Simonin, Y., van Riel, D. A. J., de Perre, P. V., Rockx, B., & Salinas, S. (2017) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0005821 · Cited by 122
Antiviral CD8 T cells induce Zika-virus-associated paralysis in mice
Jurado, K. A., Yockey, L. J., Wong, P., Lee, S., Huttner, A. J., & Iwasaki, A. (2017) · Nature Microbiology · doi:10.1038/s41564-017-0060-z · Cited by 121
Beaver, J. T., Lelutiu, N. B., Habib, R., & Skountzou, I. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01640 · Cited by 121
Chan, J. F., Zhang, J., Chan, C. C., Yip, C. C., Mak, W. W. N., Zhu, H., Poon, V. K., Tee, K., Zhu, Z., Cai, J., et al. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.11.017 · Cited by 120
Development of a Zika Virus Infection Model in Cynomolgus Macaques
Koide, F., Goebel, S. J., Snyder, B. A., Walters, K., Gast, A., Hagelin, K., Kalkeri, R., & Rayner, J. O. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.02028 · Cited by 113
Zika virus infection: an update
Ferraris, P., Yssel, H., & Missé, D. (2019) · Microbes and Infection · doi:10.1016/j.micinf.2019.04.005 · Cited by 126
Boeuf, P., Drummer, H. E., Richards, J. S., Scoullar, M. J. L., & Beeson, J. G. (2016) · BMC Medicine · doi:10.1186/s12916-016-0660-0 · Cited by 113
Preventative Vaccines for Zika Virus Outbreak: Preliminary Evaluation
Kim, E., Erdös, G., Huang, S., Kenniston, T. W., Falo, L. D., & Gambotto, A. A. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.09.028 · Cited by 111
Xavier‐Neto, J., Carvalho, M. D. O., Pascoalino, B. S., Cardoso, A. C., Costa, Â. M. S., Pereira, A. H. M., Santos, L. N., Saito, Â., Marques, R. E., Smetana, J. H. C., et al. (2017) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0005363 · Cited by 111
Zika Virus Encoding Nonglycosylated Envelope Protein Is Attenuated and Defective in Neuroinvasion
Annamalai, A. S., Pattnaik, A., Sahoo, B. R., Muthukrishnan, E., Natarajan, S. K., Steffen, D. J., Vu, H. L. X., Delhon, G. A., Osorio, F. A., Petro, T. M., et al. (2017) · Journal of Virology · doi:10.1128/jvi.01348-17 · Cited by 109
Ferreira, A. C., Zaverucha-do-Valle, C., Reis, P. A., Barbosa-Lima, G., Vieira, Y. R., Mattos, M., Silva, P. D. P., Sacramento, C. Q., Neto, H. C. D. C. F., Campanati, L., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-09797-8 · Cited by 106
Smith, D. R., Hollidge, B. S., Daye, S. P., Zeng, K. X., Blancett, C. D., Kuszpit, K. K., Bocan, T. M. A., Koehler, J. W., Coyne, S. R., Minogue, T., et al. (2017) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0005296 · Cited by 107
Wang, S., Li, W., Wang, Z., Yang, W., Li, E., Xia, X., Yan, F., & Chiu, S. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01917-x · Cited by 124
Viral infections in humans and mice with genetic deficiencies of the type I IFN response pathway
Meyts, I., & Casanova, J. (2021) · European Journal of Immunology · doi:10.1002/eji.202048793 · Cited by 112
Zika Virus Tissue and Blood Compartmentalization in Acute Infection of Rhesus Macaques
Coffey, L. L., Pesavento, P. A., Keesler, R. I., Singapuri, A., Watanabe, J., Watanabe, R., Yee, J. L., Bliss‐Moreau, E., Cruzen, C., Christe, K. L., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171148 · Cited by 94
Zika infection and the development of neurological defects
Russo, F. B., Jungmann, P., & Beltrão-Braga, P. C. B. (2017) · Cellular Microbiology · doi:10.1111/cmi.12744 · Cited by 100
Epidemiological and ecological determinants of Zika virus transmission in an urban setting
Lourenço, J., de Lima, M. M., Faria, N. R., Walker, A., Kraemer, M. U. G., Villabona‐Arenas, C. J., Lambert, B. C., de Cerqueira, E. M., Pybus, O. G., Alcantara, L., et al. (2017) · eLife · doi:10.7554/elife.29820 · Cited by 94
The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication
Zhuang, X., Magrì, A., Hill, M. L., Lai, A. G., Kumar, A., Rambhatla, S. B., Donald, C. L., Lopez‐Clavijo, A. F., Rudge, S. A., Pinnick, K. E., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08299-7 · Cited by 100
Chen, J., Liang, Y., Yi, P., Xu, L., Hawkins, H. K., Rossi, S. L., Soong, L., Cai, J., Menon, R., & Sun, J. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.10.059 · Cited by 98
Walpita, P., Cong, Y., Jahrling, P. B., Rojas, O., Postnikova, E. N., Yú, S., Johns, L. M., & Holbrook, M. R. (2017) · npj Vaccines · doi:10.1038/s41541-017-0023-7 · Cited by 93
Rao, L., Wang, W., Meng, Q., Tian, M., Cai, B., Wang, Y., Li, A., Zan, M., Xiao, F., Bu, L., et al. (2018) · Nano Letters · doi:10.1021/acs.nanolett.8b03913 · Cited by 83
Huang, W., Abraham, R., Shim, B.-S., Choe, H., & Page, D. T. (2016) · Scientific Reports · doi:10.1038/srep34793 · Cited by 81
A CRISPR Activation Screen Identifies Genes That Protect against Zika Virus Infection
Dukhovny, A., Lamkiewicz, K., Chen, Q., Fricke, M., Jabrane‐Ferrat, N., Marz, M., Jung, J. U., & Sklan, E. H. (2019) · Journal of Virology · doi:10.1128/jvi.00211-19 · Cited by 78
Pathophysiology and Mechanisms of Zika Virus Infection in the Nervous System
Christian, K. M., Song, H., & Ming, G. (2019) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-080317-062231 · Cited by 79
Zika virus: from pathogenesis to disease control
Barzon, L., Trevisan, M., Sinigaglia, A., Lavezzo, E., & Palù, G. (2016) · FEMS Microbiology Letters · doi:10.1093/femsle/fnw202 · Cited by 78
A VSV-based Zika virus vaccine protects mice from lethal challenge
Emanuel, J., Callison, J. A., Dowd, K. A., Pierson, T. C., Feldmann, H., & Marzi, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-29401-x · Cited by 76
Zika Virus Fatally Infects Wild Type Neonatal Mice and Replicates in Central Nervous System
Li, S., Armstrong, N., Zhao, H., Hou, W., Liu, J., Chen, C.-Y., Wan, J., Wang, W., Zhong, C., Liu, C., et al. (2018) · Viruses · doi:10.3390/v10010049 · Cited by 73
Zika Virus Attenuation by Codon Pair Deoptimization Induces Sterilizing Immunity in Mouse Models
Li, P., Ke, X., Wang, T., Tan, Z., Luo, D., Miao, Y., Sun, J., Zhang, Y., Liu, Y., Hu, Q., et al. (2018) · Journal of Virology · doi:10.1128/jvi.00701-18 · Cited by 74
African and Asian Zika Virus Isolates Display Phenotypic Differences Both In Vitro and In Vivo
Smith, D. R., Sprague, T. R., Hollidge, B. S., Trefry, S. V., Padilla, S. L., Bellanca, S. A., Golden, J. W., Coyne, S. R., Kulesh, D. A., Miller, L. J., et al. (2017) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.17-0685 · Cited by 73
Hui, L., Nie, Y., Li, S., Guo, M., Yang, W. Z., Huang, R., Chen, J., Liu, Y., Lu, X., Chen, Z., et al. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008509 · Cited by 68
A guinea pig model of Zika virus infection
Kumar, M., Krause, K. K., Azouz, F., Nakano, E. T., & Nerurkar, V. R. (2017) · Virology Journal · doi:10.1186/s12985-017-0750-4 · Cited by 69
Dowall, S., Graham, V., Rayner, E. L., Hunter, L. E., Atkinson, B., Pearson, G., Dennis, M. J., & Hewson, R. (2017) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0005704 · Cited by 60
Self-citationViral Retinopathy in Experimental Models of Zika Infection
Zhao, Z., Yang, M., Azar, S. R., Soong, L., Weaver, S. C., Sun, J., Chen, Y., Rossi, S. L., & Cai, J. (2017) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.17-22016 · Cited by 63
Natural Products Isolated from Oriental Medicinal Herbs Inactivate Zika Virus
Batista, M. N., Braga, A. C. S., Campos, G. R. F., de Souza, M. M., de Matos, R. P. A., Lopes, T. Z., Cândido, N. M., Lima, M. L. D., Machado, F. C., de Andrade, S. T. Q., et al. (2019) · Viruses · doi:10.3390/v11010049 · Cited by 61
Zika virus impairs the development of blood vessels in a mouse model of congenital infection
Garcez, P. P., Stolp, H. B., Sravanam, S., Christoff, R. R., Ferreira, J. C. C. G., Dias, A. A., Pezzuto, P., Higa, L. M., Barbeito‐Andrés, J., Ferreira, R. O., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-31149-3 · Cited by 61
Zika virus pathogenesis and current therapeutic advances
Mwaliko, C., Nyaruaba, R., Zhao, L., Atoni, E., Karungu, S., Mwau, M., Lavillette, D., Xia, H., & Yuan, Z. (2020) · Pathogens and Global Health · doi:10.1080/20477724.2020.1845005 · Cited by 65
Barbosa-Lima, G., Moraes, A. M., Araújo, A. D. S., da Silva, E. T., de Freitas, C. S., Vieira, Y. R., Marttorelli, A., Cerbino-Neto, J., Bozza, P. T., Souza, M. V. N. D., et al. (2016) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.12.058 · Cited by 58
Cheng, F., da Silva, S. R., Huang, I., Jung, J. U., & Gao, S. (2017) · Journal of Virology · doi:10.1128/jvi.02019-17 · Cited by 55
Zika virus induces oxidative stress and decreases antioxidant enzyme activities in vitro and in vivo
Almeida, L. T., Ferraz, A. C., Caetano, C. C. D. S., Menegatto, M. B. D. S., Andrade, A. C. D. S. P., Lima, R. L. S., Camini, F. C., Pereira, S. H., Pereira, K. Y. D. S., Silva, B. D. M., et al. (2020) · Virus Research · doi:10.1016/j.virusres.2020.198084 · Cited by 57
Mechanisms of Zika Virus Infection and Neuropathogenesis
Olagnier, D. P., Muscolini, M., Coyne, C. B., Diamond, M., & Hiscott, J. B. (2016) · DNA and Cell Biology · doi:10.1089/dna.2016.3404 · Cited by 60
Guo, Q., Chan, J. F., Poon, V. K., Wu, S., Chan, C. C., Hou, L., Yip, C. C., Ren, C., Cai, J., Zhao, M., et al. (2018) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiy187 · Cited by 57
Zika Virus: What Have We Learnt Since the Start of the Recent Epidemic?
Sáiz, J., Martín-Acebes, M. A., Bueno‐Marí, R., Salomón, O. D., Jiménez, L. C. V., Heukelbach, J., Alencar, C. H., Armstrong, P., Ortiga-Carvalho, T. M., Méndez‐Otero, R., et al. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01554 · Cited by 54
Chen, T., Wu, S., Yang, J., & Cong, G. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16234677 · Cited by 55
In vitro and in vivo models for studying Zika virus biology
Pena, L., Guarines, K. M., Silva, A. J. D., Leal, L. R. S., Félix, D. M., Silva, A., de Oliveira, S. A., Ayres, C. F. J., Silva‐Júnior, A., & de Freitas, A. C. (2018) · Journal of General Virology · doi:10.1099/jgv.0.001153 · Cited by 55
Mouse vs man: Organoid models of brain development & disease
Marshall, J. J., & Mason, J. O. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146427 · Cited by 54
Intranasal infection and contact transmission of Zika virus in guinea pigs
Deng, Y., Zhang, N., Li, X., Wang, Y., Tian, M., Qiu, Y., Fan, J., Hao, J., Huang, X., Dong, H.-L., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01923-4 · Cited by 56
Suppression of Type I Interferon Signaling by Flavivirus NS5
Thurmond, S., Wang, B., Song, J., & Hai, R. (2018) · Viruses · doi:10.3390/v10120712 · Cited by 56
Growth and adaptation of Zika virus in mammalian and mosquito cells
Moser, L. A., Boylan, B. T., Moreira, F. R., Myers, L. J., Svenson, E. L., Fedorova, N. B., Pickett, B. E., & Bernard, K. A. (2018) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0006880 · Cited by 51
Biologic Evidence Required for Zika Disease Enhancement by Dengue Antibodies
Halstead, S. B. (2017) · Emerging infectious diseases · doi:10.3201/eid2304.161879 · Cited by 51
Shpichka, A. I., Bikmulina, P., Peshkova, M., Kosheleva, N. V., Михайловна, З. И., Zahmatkesh, E., Rad, N. K., Lipina, M., Голубева, Е. Н., Butnaru, D. V., et al. (2020) · International Journal of Bioprinting · doi:10.18063/ijb.v6i4.302 · Cited by 52
Glycosylated diphyllin as a broad-spectrum antiviral agent against Zika virus
Martínez‐López, A., Persaud, M., Puray‐Chavez, M., Zhang, H., Rong, L., Liu, S., Wang, T. T., Sarafianos, S. G., & Diaz‐Griffero, F. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.08.060 · Cited by 49
Suwanmanee, S., & Luplertlop, N. (2017) · The Journal of Microbiology · doi:10.1007/s12275-017-6494-4 · Cited by 47
Zika virus outbreak: a review of neurological complications, diagnosis, and treatment options
Koppolu, V., & Raju, T. S. (2018) · Journal of NeuroVirology · doi:10.1007/s13365-018-0614-8 · Cited by 52
Soto-Acosta, R., Xie, X., Shan, C., Baker, C. K., Shi, P., Rossi, S. L., García-Blanco, M. A., & Bradrick, S. S. (2018) · eLife · doi:10.7554/elife.39023 · Cited by 48
Deleterious effect of Usutu virus on human neural cells
Salinas, S., Constant, O., Desmetz, C., Barthelemy, J., Lemaı̂tre, J.-M., Milhavet, O., Nagot, N., Foulongne, V., Perrin, F. E., Sáiz, J., et al. (2017) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0005913 · Cited by 46
Modeling Arboviral Infection in Mice Lacking the Interferon Alpha/Beta Receptor
Marín-López, A., Calvo-Pinilla, E., Moreno, S., Utrilla-Trigo, S., Nogales, A., Brun, A., Fikrig, E., & Ortego, J. (2019) · Viruses · doi:10.3390/v11010035 · Cited by 45
Lei, J., Vermillion, M. S., Jia, B., Xie, H., Xie, L. H., McLane, M. W., Sheffield, J. S., Pekosz, A. S., Brown, A. M., Klein, S. L., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.122678 · Cited by 46
A recombinant virus vaccine that protects against both Chikungunya and Zika virus infections
Chattopadhyay, A., Aguilar, P. V., Bopp, N. E., Yarovinsky, T. O., Weaver, S. C., & Rose, J. K. (2018) · Vaccine · doi:10.1016/j.vaccine.2018.05.095 · Cited by 43
Chan, J. F., Zhu, Z., Chu, H., Yuan, S., Chik, K. K., Chan, C. C., Poon, V. K., Yip, C. C., Zhang, X., Tsang, J. O., et al. (2018) · Antiviral Research · doi:10.1016/j.antiviral.2018.10.007 · Cited by 44
Protective to a T: The Role of T Cells during Zika Virus Infection
Pardy, R. D., & Richer, M. J. (2019) · Cells · doi:10.3390/cells8080820 · Cited by 45
Willard, K. A., Demakovsky, L. R., Tesla, B., Goodfellow, F. T., Stice, S. L., Murdock, C. C., & Brindley, M. A. (2017) · Viruses · doi:10.3390/v9120383 · Cited by 44
Winkler, C. W., Woods, T. A., Rosenke, R., Scott, D. P., Best, S. M., & Peterson, K. E. (2017) · Scientific Reports · doi:10.1038/s41598-017-07099-7 · Cited by 42
Dysregulated metabolism underpins Zika-virus-infection-associated impairment in fetal development
Yau, C., Low, J. Z. H., Gan, E. S., Kwek, S. S., Liang, C., Tan, H. C., Mok, D. Z. L., Chan, C. Y. Y., Sessions, O. M., Watanabe, S., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.110118 · Cited by 42
Natural products as Zika antivirals
Fong, Y. D., & Chu, J. J. H. (2022) · Medicinal Research Reviews · doi:10.1002/med.21891 · Cited by 41
Metadata
- Authors
- Dowall, S. D., Graham, V. A., Rayner, E., Atkinson, B., Hall, G., Watson, R. J., Bosworth, A., Bonney, L. C., Kitchen, S., & Hewson, R.
- Affiliations
- Public Health England (GB)
- Corresponding author
- Dowall, Stuart D.
- Graham, Victoria A.
- Rayner, Emma
- Atkinson, Barry
- Hall, Graham
- Watson, Robert J.
- Bosworth, Andrew
- Bonney, Laura C.
- Kitchen, Samantha
- Hewson, Roger
- ORCID
- Venue
- PLoS neglected tropical diseases
- Publisher
- Public Library of Science (PLoS)
- Published
- 2016-05-05
- Volume
- 10
- Issue
- 5
- Pages
- e0004658
- ISSN
- 1935-2727 (ISSN-L)
- 1935-2735
- PMC
- PMC4858159
- OpenAlex
- W2345638947
- Cited by
- 323
- References
- 65
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 9 · 2023: 10 · 2022: 13 · 2021: 44 · 2020: 31 · 2019: 42 · 2018: 50 · 2017: 70 · 2016: 36
- FWCI
- 65.45
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS neglected tropical diseases (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Public Health England (Not applicable)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Vectors
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Outbreaks Research
- Keywords
- Zika virus, mouse infection model, subcutaneous challenge, mosquito bites, vaccine testing, microcephaly, Guillain-Barré syndrome, histopathology
- MeSH terms
- Zika Virus Infection, Zika Virus, Animals, Brain, Disease Models, Animal, Disease Susceptibility, Female, RNA, Viral, Mice, Knockout, Mice, Receptor, Interferon alpha-beta
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
