Scabies: advances in noninvasive diagnosis.
Open accessAbstract
Scabies is a common, highly contagious skin parasitosis caused by Sarcoptes scabiei var. hominis. Early identification and prompt treatment of infested subjects is essential, as missed diagnosis may result in outbreaks, considerable morbidity, and significantly increased economic burden. The standard diagnostic technique consists of mites' identification by microscopic examination of scales obtained by skin scraping. This is a time-consuming and risk-associated procedure that is also not suitable to a busy practice. In recent years, some advanced and noninvasive techniques such as videodermatoscopy, dermatoscopy, reflectance confocal microscopy, and optical coherence tomography have demonstrated improved efficacy in the diagnosis of scabies. Their advantages include rapid, noninvasive mass screening and post-therapeutic follow-up, with no physical risk. A greater knowledge of these techniques among general practitioners and other specialists involved in the intake care of overcrowded populations vulnerable to scabies infestations is now viewed as urgent and important in the management of outbreaks, as well as in consideration of the recent growing inflow of migrants in Europe from North Africa.
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Noninvasive examination of affected skin by using videodermatoscopy, videomicroscopy, or dermoscopy has high sensitivity and specificity, particularly when performed by experienced operators.
“Alternatively, noninvasive examination of the affected skin by using videodermatoscopy, videomicroscopy, or dermoscopy can be used, each of which has high sensitivity and specificity, particularly when performed by experienced operators (1404).”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [1404]
The Videodermatoscopy section describes videodermatoscopy as sensitive and virtually 100% specific at higher magnifications, and reports that low-cost videomicroscopes detected the same diagnostic findings in a small comparison. The Dermoscopy section reports sensitivity of 83%–91% but specificity of 86% in one study and only 46% in another. It also says operator experience affects specificity, not sensitivity, so the claim that each method has high sensitivity and specificity overstates the evidence. (LLM, conf=0.89)
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- Authors
- Micali, G., Lacarrubba, F., Verzì, A. E., Chosidow, O., & Schwartz, R. A.
- Affiliations
- University of Catania (IT)
- Hôpital Tenon (FR)
- Rutgers, The State University of New Jersey (US)
- Corresponding author
- Micali, Giuseppe
- Venue
- PLoS neglected tropical diseases
- Publisher
- Public Library of Science (PLoS)
- Published
- 2016-06-16
- Volume
- 10
- Issue
- 6
- Pages
- e0004691
- ISSN
- 1935-2727 (ISSN-L)
- 1935-2735
- PMC
- PMC4911127
- OpenAlex
- W2443130410
- Cited by
- 129
- References
- 61
- Citations by year
- 2026: 11 · 2025: 11 · 2024: 17 · 2023: 14 · 2022: 9 · 2021: 13 · 2020: 19 · 2019: 13 · 2018: 15 · 2017: 7
- FWCI
- 1.79
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS neglected tropical diseases (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Dermatological diseases and infestations
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Epidemiology › Nail Diseases and Treatments
- Keywords
- scabies, Sarcoptes scabiei var. hominis, non-invasive diagnosis, videodermatoscopy, dermoscopy, reflectance confocal microscopy, optical coherence tomography, skin scraping, mass screening, epidemic control, migrants, Maghrebi immigrants
- MeSH terms
- Animals, Humans, Sarcoptes scabiei, Scabies, Microscopy, Confocal, Tomography, Optical Coherence, Dermoscopy
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