Cited by 232Adrenal and Paraganglionic TumorsCancer, Hypoxia, and MetabolismEar and Head Tumors

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

The Warburg Effect Is Genetically Determined in Inherited Pheochromocytomas

Open access

Favier, Judith, Brière, Jean-Jacques, Burnichon, Nelly, Rivière, Julie, Vescovo, Laure, Benit, Paule, Giscos-Douriez, Isabelle, De Reyniès, Aurélien, Bertherat, Jérôme, Badoual, Cécile, Tissier, Frédérique, Amar, Laurence, Libé, Rosella, Plouin, Pierre-François, Jeunemaitre, Xavier, Rustin, Pierre, Gimenez-Roqueplo, Anne-Paule·2009·PLoS ONE

DOI 10.1371/journal.pone.0007094PMC PMC2738974

Open this paper in CoChat — free account Open PDF

Abstract

The Warburg effect describes how cancer cells down-regulate their aerobic respiration and preferentially use glycolysis to generate energy. To evaluate the link between hypoxia and Warburg effect, we studied mitochondrial electron transport, angiogenesis and glycolysis in pheochromocytomas induced by germ-line mutations in VHL, RET, NF1 and SDH genes. SDH and VHL gene mutations have been shown to lead to the activation of hypoxic response, even in normoxic conditions, a process now referred to as pseudohypoxia. We observed a decrease in electron transport protein expression and activity, associated with increased angiogenesis in SDH- and VHL-related, pseudohypoxic tumors, while stimulation of glycolysis was solely observed in VHL tumors. Moreover, microarray analyses revealed that expression of genes involved in these metabolic pathways is an efficient tool for classification of pheochromocytomas in accordance with the predisposition gene mutated. Our data suggest an unexpected association between pseudohypoxia and loss of p53, which leads to a distinct Warburg effect in VHL-related pheochromocytomas.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1371/journal.pone.0007094

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Figure 1 Pseudohypoxia in SDH and VHL-related PH/PGL. (A) HIF-1α and HIF-2α immunohistochemistry were performed to evaluate activation of the hypoxic pathway in all samples. Histogreen was used as a chromogen for detection (blue labeling). Calibration bar: 100 µm. Microarray evaluation of HIF-1α (B) and HIF-2α (C) expression between SDH, VHL, RET and NF1 tumors. Data are means±SEM. ***p<0.001.CC BY · PubMed Central

Figure 2 Angiogenesis in SDH and VHL-related PH/PGL. (A) CD34 immunohistochemistry was performed to evaluate angiogenesis in all samples. Diaminobenzidin was used as a chromogen for detection (brown labeling). Calibration bar: 200 µm. (B) Quantification of vascular density showing an increased number of blood vessels in SDH, and VHL tissues. Data are means±SEM. *p<0.05, **p<0.01, ***p<0.001. (C) Correlation between vascular density and SCCR enzymatic values for individual patients.CC BY · PubMed Central

Figure 3 Decreased oxidative phosphorylation in SDH and VHL-related PH/PGL. (A) The abundance of proteins of mitochondrial complexes I (20 kDa subunit), II (SDHB and SDHA), III (Core 2) and IV (Cox II) is lower in PH/PGL from SDH and most VHL than from RET and tumor tissues. (B) SDHB immunohistochemistry performed on the adrenal adjacent to a RET-related PH and in RET, VHL and SDHD-mutated PH reveals a strong labeling in the adrenal compared to tumor cells (asterisks). In VHL PH/PGL tumor, expression of SDHB was reduced when compared to RET-related PH while it is absent in SDHD-related tumor. Note that vascular immunostaining was present in all samples (arrows). Calibration bar: 50 µm. (C) Individual values of SCCR activity reveal that low complex II+III enzymatic activity is associated with low protein abundance. (D–F) Mean values for mitochondrial complexes II+III, III and IV reveal a generalized decrease in respiration in SDH and VHL PH/PGL. Data are means±SEM. **p<0.01, ***p<0.001.CC BY · PubMed Central

Figure 4 Increased glycolysis in VHL-related PH/PGL. (A) Hexokinase-II protein is detected in all VHL PH/PGL but is hardly detectable in RET, NF1 and SDH samples. (B) Lactate dehydrogenase is increased in tumors harboring a VHL mutation as compared to SDH, RET and NF1 tumors.CC BY · PubMed Central

Figure 5 Microarray analysis of oxidative phosphorylation in hereditary PH/PGL. (A) Unsupervised hierarchical clustering analysis of the 68 samples according to the expression of 200 genes. Expression profiles are shown as a heat map indicating high (red) and low (blue) expression according to a log2-transformed scale. The higher bipartition allows to distinguish VHL (white) and SDH (grey) patients from RET and NF1 (black) patients. (B) Principal component analysis of the 68 samples according to the expression of 200 genes. Three groups are focused on, corresponding to the SDH (red), VHL (green) and RET/NF1 (blue) patients. PC1: principal component; PC2: principal component 2; PC3: principal component 3. (C) Mean values for genes expression between SDH, VHL, RET and NF1 tumors. Data are means±SEM, represented as relative to NF1 expression values. **p<0.01, ***p<0.001.CC BY · PubMed Central

Figure 6 Microarray analysis of glycolysis in hereditary PH/PGL. (A) Unsupervised hierarchical clustering analysis of the 68 samples according to the expression of 38 genes. Expression profiles are shown as a heat map indicating high (red) and low (blue) expression according to a log2-transformed scale. The different mutations are localized in three distinct clusters: SDH (grey), VHL (white) and RET/NF1 (black). (B) Mean values for genes expression between SDH, VHL, RET and NF1 tumors. Data are means±SEM, represented as relative to NF1 expression values. **p<0.01, ***p<0.001.CC BY · PubMed Central

Figure 7 Representative expression of p53 and TIGAR in PH/PGL. Immunohistochemistry revealed a mild to strong nuclear p53 labeling, and the cystoplasmic expression of TIGAR in the majority of RET, NF1 and SDH tumors. Such labeling was only detected in 2 out of 9 VHL tumor tissues (data not shown). In most VHL PH/PGL p53 protein and its target TIGAR were hardly detectable. Calibration bar: 50 µm.CC BY · PubMed Central

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197
Bioconductor: open software development for computational biology and bioinformatics
Gentleman, R. C., Carey, V. J., Bates, D. M., Bolstad, B., Dettling, M., Dudoit, S., Ellis, B., Gautier, L., Ge, Y., Gentry, J., et al. (2004) · Genome biology · doi:10.1186/gb-2004-5-10-r80 · Cited by 12,082
Exploration, normalization, and summaries of high density oligonucleotide array probe level data
Irizarry, R. A. (2003) · Biostatistics · doi:10.1093/biostatistics/4.2.249 · Cited by 10,603
Targeting HIF-1 for cancer therapy
Semenza, G. L. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1187 · Cited by 6,717
On Respiratory Impairment in Cancer Cells
Warburg, O. H. (1956) · Science · doi:10.1126/science.124.3215.269 · Cited by 3,472
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase
Selak, M. A., Armour, S. M., MacKenzie, E. D., Boulahbel, H., Watson, D. G., Mansfield, K. D., Pan, Y., Simon, M. C., Thompson, C. B., & Gottlieb, E. (2005) · Cancer Cell · doi:10.1016/j.ccr.2004.11.022 · Cited by 2,108
TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis
Bensaad, K., Tsuruta, A., Selak, M. A., Vidal, M. N. C., Nakano, K., Bartrons, R., Gottlieb, E., & Vousden, K. H. (2006) · Cell · doi:10.1016/j.cell.2006.05.036 · Cited by 2,019
p53 Regulates Mitochondrial Respiration
Matoba, S., Kang, J.-G., Patino, W. D., Wragg, A., Boehm, M., Gavrilova, O., Hurley, P. J., Bunz, F., & Hwang, P. M. (2006) · Science · doi:10.1126/science.1126863 · Cited by 1,650
HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells
Fukuda, R., Zhang, H., Kim, J.-W., Shimoda, L., Dang, C. V., & Semenza, G. L. (2007) · Cell · doi:10.1016/j.cell.2007.01.047 · Cited by 1,225
Role of VHL Gene Mutation in Human Cancer
Kim, W. Y., & Kaelin, W. G. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.05.061 · Cited by 953
HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity
Zhang, H., Gao, P., Fukuda, R., Kumar, G., Krishnamachary, B., Zeller, K. I., Dang, C. V., & Semenza, G. L. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.04.001 · Cited by 885
Genetic Testing in Pheochromocytoma or Functional Paraganglioma
Amar, L., Bertherat, J. Y., Baudin, É., Ajzenberg, C., Paillerets, B. B., Chabre, O., Chamontin, B., Delemer, B., Giraud, S., Murat, A., et al. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.03.1484 · Cited by 683
Self-citation
Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer
King, A., Selak, M. A., & Gottlieb, E. (2006) · Oncogene · doi:10.1038/sj.onc.1209594 · Cited by 672
Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1
Kim, J.-W., Gao, P., Liu, Y.-C., Semenza, G. L., & Dang, C. V. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00440-07 · Cited by 658
Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation
Uldry, M., Yang, W., St‐Pierre, J., Lin, J. D., Seale, P., & Spiegelman, B. M. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.04.002 · Cited by 651
The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development
Tian, H., Hammer, R. E., Matsumoto, A. M., Russell, D. W., & McKnight, S. L. (1998) · Genes & Development · doi:10.1101/gad.12.21.3320 · Cited by 647
Hexokinase-2 bound to mitochondria: Cancer's stygian link to the “Warburg effect” and a pivotal target for effective therapy
Mathupala, S. P., Ko, Y. H., & Pedersen, P. L. (2008) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2008.11.006 · Cited by 585
An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis
van Nederveen, F. H., Gaal, J., Favier, J., Korpershoek, E., Oldenburg, R. A., de Bruyn, E. M., Sleddens, H. F. B. M., Derkx, P., Rivière, J., Dannenberg, H., et al. (2009) · The Lancet Oncology · doi:10.1016/s1470-2045(09)70164-0 · Cited by 554
Self-citation
Roles of p53, MYC and HIF-1 in regulating glycolysis–the seventh hallmark of cancer
Yeung, S. J., Pan, J., & Lee, M.-H. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8224-x · Cited by 514
Succinate Dehydrogenase B Gene Mutations Predict Survival in Patients with Malignant Pheochromocytomas or Paragangliomas
Amar, L., Baudin, É., Burnichon, N., Peyrard, S., Silvera, S., Bertherat, J. Y., BERTAGNA, X. Y., Schlumberger, M. J., Jeunemaı̂tre, X., Gimenez‐Roqueplo, A., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0709 · Cited by 447
Self-citation
A HIF1α Regulatory Loop Links Hypoxia and Mitochondrial Signals in Pheochromocytomas
Dahia, P. L. M., Ross, K. N., Wright, M. E., Hayashida, C. Y., Santagata, S., Barontini, M., Kung, A. L., Sanso, G., Powers, J. F., Tischler, A. S., et al. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0010008 · Cited by 443
Mitochondrial Uncoupling and the Warburg Effect: Molecular Basis for the Reprogramming of Cancer Cell Metabolism
Samudio, I. J., Fiegl, M., & Andreeff, M. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3722 · Cited by 309
Differential Regulation of the Transcriptional Activities of Hypoxia-Inducible Factor 1 Alpha (HIF-1α) and HIF-2α in Stem Cells
Hu, C., Iyer, S. R., Sataur, A., Covello, K. L., Chodosh, L. A., & Simon, M. C. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.9.3514-3526.2006 · Cited by 270
Proteomic changes in renal cancer and co‐ordinate demonstration of both the glycolytic and mitochondrial aspects of the Warburg effect
Unwin, R. D., Craven, R. A., Harnden, P., Hanrahan, S. J., Totty, N., Knowles, M. A., Ian Eardley, C., Selby, P. J., & Banks, R. E. (2003) · PROTEOMICS · doi:10.1002/pmic.200300464 · Cited by 246
p53 Stabilization and Transactivation by a von Hippel-Lindau Protein
Roe, J., Kim, H., Lee, S.-M., Kim, S.-T., Cho, E., & Youn, H. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.04.006 · Cited by 245
Distinct gene expression profiles in norepinephrine- and epinephrine-producing hereditary and sporadic pheochromocytomas: activation of hypoxia-driven angiogenic pathways in von Hippel–Lindau syndrome
Eisenhofer, G., Huynh, T.-T., Pacak, K., Brouwers, F. M., Walther, M. M., Linehan, W. M., Munson, P. J., Mannelli, M., Goldstein, D. S., & Elkahloun, A. G. (2004) · Endocrine-Related Cancer · doi:10.1677/erc.1.00838 · Cited by 207
Loss of p53 causes mitochondrial DNA depletion and altered mitochondrial reactive oxygen species homeostasis
Lebedeva, M. A., Eaton, J. S., & Shadel, G. S. (2009) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2009.01.004 · Cited by 191
Mitochondrial succinate is instrumental for HIF1α nuclear translocation in SDHA-mutant fibroblasts under normoxic conditions
Brière, J.-J., Favier, J., Bénit, P., Ghouzzi, V. E., Lorenzato, A., Rabier, D., Renzo, M. F. D., Gimenez‐Roqueplo, A., & Rustin, P. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi359 · Cited by 162
Self-citation
Expression of HIF-1α, HIF-2α (EPAS1), and Their Target Genes in Paraganglioma and Pheochromocytoma with VHL and SDH Mutations
Pollard, P. J., El-Bahrawy, M. A., Poulsom, R., Elia, G., Killick, P., Kelly, G. P., Hunt, T., Jeffery, R. E., Seedhar, P., Barwell, J., et al. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0920 · Cited by 140
Three spectrophotometric assays for the measurement of the five respiratory chain complexes in minuscule biological samples
Bénit, P., Gonçalves, S., Dassa, E. P., Brière, J.-J., Martin, G. R., & Rustin, P. (2006) · Clinica Chimica Acta · doi:10.1016/j.cca.2006.05.034 · Cited by 101
Self-citation
Hereditary Paraganglioma/Pheochromocytoma and Inherited Succinate Dehydrogenase Deficiency
Favier, J., Brière, J.-J., Strompf, L., Amar, L., Filali, M., Jeunemaı̂tre, X., Rustin, P., & Gimenez‐Roqueplo, A. (2005) · Hormone Research in Paediatrics · doi:10.1159/000084685 · Cited by 92
Self-citation
A new role for the von Hippel-Lindau tumor suppressor protein: stimulation of mitochondrial oxidative phosphorylation complex biogenesis
Hervouet, É. (2004) · Carcinogenesis · doi:10.1093/carcin/bgi001 · Cited by 91
Novel MLLCBP fusion transcript in therapy‐related chronic myelomonocytic leukemia with a t(11;16) (q23;p13) chromosome translocation
Satake, N., Ishida, Y., Otoh, Y., Hinohara, S., Kobayashi, H., Sakashita, A., Maseki, N., & Kaneko, Y. (1997) · Genes Chromosomes and Cancer · doi:10.1002/(sici)1098-2264(199709)20:1 · Cited by 91
Proteomic analysis of primary cell lines identifies protein changes present in renal cell carcinoma
Craven, R. A., Stanley, A. J., Hanrahan, S. J., Dods, J. S., Unwin, R. D., Totty, N., Harnden, P., Ian Eardley, C., Selby, P. J., & Banks, R. E. (2006) · PROTEOMICS · doi:10.1002/pmic.200500549 · Cited by 76
HIF-2α expression in human fetal paraganglia and neuroblastoma: relation to sympathetic differentiation, glucose deficiency, and hypoxia
Nilsson, H., Jögi, A., Beckman, S., Harris, A. L., Poellinger, L., & Påhlman, S. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.10.003 · Cited by 75
Role of positron emission tomography and bone scintigraphy in the evaluation of bone involvement in metastatic pheochromocytoma and paraganglioma: specific implications for succinate dehydrogenase enzyme subunit B gene mutations
Zelinka, T., Timmers, H. J. L. M., Kozupa, A., Chen, C. C., Carrasquillo, J. A., Reynolds, J. C., Ling, A. L., Eisenhofer, G., Lazúrová, I., Adams, K. T., et al. (2008) · Endocrine Related Cancer · doi:10.1677/erc-07-0217 · Cited by 67
Cloning and expression pattern of EPAS1 in the chicken embryo
Favier, J., Kempf, H., Corvol, P. L., & Gasc, J. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01476-3 · Cited by 51
Self-citation
Mitochondria and Cancer
Rustin, P., & Kroemer, G. (2008) · Ernst Schering Research Foundation workshop/Ernst Schering Foundation Symposium proceedings · doi:10.1007/2789_2008_086 · Cited by 46
Self-citation
The relatively high frequency of p53 gene mutations in multiple and malignant phaeochromocytomas
Yoshimoto, T., Naruse, M., Zeng, Z., Nishikawa, T., Kasajima, T., Toma, H., Yamamori, S., Matsumoto, H., Tanabe, A., Naruse, K., et al. (1998) · Journal of Endocrinology · doi:10.1677/joe.0.1590247 · Cited by 40
Frequent loss of 17p, but no p53 mutations or protein overexpression in benign and malignant pheochromocytomas
Petri, B., Speel, E. M., Korpershoek, E., Claessen, S. M. H., van Nederveen, F. H., Giesen, V., Dannenberg, H., van der Harst, E., Dinjens, W. N. M., & de Krijger, R. R. (2008) · Modern Pathology · doi:10.1038/modpathol.3801013 · Cited by 29
Transcriptional adaptation of neuroblastoma cells to hypoxia
Fredlund, E., Ovenberger, M., Borg, Å., & Påhlman, S. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.12.074 · Cited by 25
Mitochondria and Cancer
Owens, K. M., Modica-Napolitano, J. S., & Singh, K. K. (2008) · Springer eBooks · doi:10.1007/978-0-387-84835-8_1 · Cited by 21

Sorted by citations

SDH mutations establish a hypermethylator phenotype in paraganglioma
Letouzé, E., Martinelli, C., Loriot, C., Burnichon, N., Abermil, N., Ottolenghi, C., Janin, M., Menara, M., Nguyen, A. T., Benit, P., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.04.018 · Cited by 776
Self-citation
Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer
Wigerup, C., Påhlman, S., & Bexell, D. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.04.009 · Cited by 687
“Interestingly, the tumorigenesis of these closely related tumors seems to involve aberrant HIF-2 signaling, resulting in pseudohypoxic phenotypes linked to disseminated disease (Eisenhofer et al., 2004; Pietras et al., 2008; Favier et al., 2009).”
Background
Cancer as a metabolic disease
Seyfried, T. N., & Shelton, L. M. (2010) · Nutrition & Metabolism · doi:10.1186/1743-7075-7-7 · Cited by 675
SDHA is a tumor suppressor gene causing paraganglioma
Burnichon, N., Brière, J.-J., Libé, R., Vescovo, L., Rivière, J., Tissier, F., Jouanno, E., Jeunemaı̂tre, X., Bénit, P., Tzagoloff, A., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq206 · Cited by 645
Self-citation
Exome sequencing identifies MAX mutations as a cause of hereditary pheochromocytoma
Comino‐Méndez, I., Gracia-Aznárez, F. J., Schiavi, F., Landa, I., Leandro-Garcia, L. J., Letón, R., Honrado, E., Ramos‐Medina, R., Caronia, D., Pita, G., et al. (2011) · Nature Genetics · doi:10.1038/ng.861 · Cited by 528

See all 232

Authors: Favier, J., Brière, J.-J., Burnichon, N., Rivière, J., Vescovo, L., Benit, P., Giscos-Douriez, I., De Reyniès, A., Bertherat, J., Badoual, C., Tissier, F., Amar, L., Libé, R., Plouin, P.-F., Jeunemaitre, X., Rustin, P., & Gimenez-Roqueplo, A.-P.
Affiliations: Inserm (FR)
La Ligue Contre le Cancer (FR)
Assistance Publique – Hôpitaux de Paris (FR)
Hôpital Cochin (FR)
Corresponding author: Favier, Judith
ORCID: Favier, Judith
Burnichon, Nelly
Rivière, Julie
De Reyniès, Aurélien
Badoual, Cécile
Amar, Laurence
Rustin, Pierre
Venue: PLoS ONE
Publisher: Public Library of Science (PLoS)
Published: 2009-09-18
Volume: 4
Issue: 9
Pages: e7094
ISSN: 1932-6203 (ISSN-L)
DOI: 10.1371/journal.pone.0007094
PMC: PMC2738974
OpenAlex: W2063687158
Cited by: 232
References: 42
Citations by year: 2026: 7 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 10 · 2021: 7 · 2020: 12 · 2019: 13 · 2018: 14 · 2017: 11 · 2016: 15 · 2015: 28 · 2014: 27 · 2013: 16 · 2012: 27
FWCI: 20.62
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: PLoS ONE (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Association pour la Recherche sur le Cancer
Agence Nationale de la Recherche
GIS-Institut des Maladies Rares
Topics: Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Health Sciences › Medicine › Oncology › Ear and Head Tumors
Keywords: Warburg effect, pheochromocytoma, pseudohypoxia, VHL gene, SDH genes, RET proto-oncogene, NF1 gene, mitochondrial electron transport chain, angiogenesis, glycolysis, p53 deficiency, cancer metabolism, germline mutations, gene expression profiling
MeSH terms: Adolescent, Adult, Aged, Hypoxia, Child, Electron Transport, Female, Glycolysis, Humans, Male, Middle Aged, Mitochondria, Neovascularization, Pathologic, Oxidative Phosphorylation, Pheochromocytoma, Genes, p53, Germ-Line Mutation, Oligonucleotide Array Sequence Analysis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Warburg Effect Is Genetically Determined in Inherited Pheochromocytomas

Abstract

Overview

Integrity signals

Figures

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks