The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Comprehensive Analysis of Inflammatory Immune Mediators in Vitreoretinal Diseases
Open accessAbstract
Inflammation affects the formation and the progression of various vitreoretinal diseases. We performed a comprehensive analysis of inflammatory immune mediators in the vitreous fluids from total of 345 patients with diabetic macular edema (DME, n = 92), proliferative diabetic retinopathy (PDR, n = 147), branch retinal vein occlusion (BRVO, n = 30), central retinal vein occlusion (CRVO, n = 13) and rhegmatogenous retinal detachment (RRD, n = 63). As a control, we selected a total of 83 patients with either idiopathic macular hole (MH) or idiopathic epiretinal membrane (ERM) that were free of major pathogenic intraocular changes, such as ischemic retina and proliferative membranes. The concentrations of 20 soluble factors (nine cytokines, six chemokines, and five growth factors) were measured simultaneously by multiplex bead analysis system. Out of 20 soluble factors, three factors: interleukin-6 (IL-6), interleukin-8 (IL-8), and monocyte chemoattractant protein-1 (MCP-1) were significantly elevated in all groups of vitreoretinal diseases (DME, PDR, BRVO, CRVO, and RRD) compared with control group. According to the correlation analysis in the individual patient's level, these three factors that were simultaneously increased, did not show any independent upregulation in all the examined diseases. Vascular endothelial growth factor (VEGF) was significantly elevated in patients with PDR and CRVO. In PDR patients, the elevation of VEGF was significantly correlated with the three factors: IL-6, IL-8, and MCP-1, while no significant correlation was observed in CRVO patients. In conclusion, multiplex bead system enabled a comprehensive soluble factor analysis in vitreous fluid derived from variety of patients. Major three factors: IL-6, IL-8, and MCP-1 were strongly correlated with each other indicating a common pathway involved in inflammation process in vitreoretinal diseases.
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Cited by
Clinical evidence of sustained chronic inflammatory reaction in retinitis pigmentosa
Yoshida, N., Ikeda, Y., Notomi, S., Ishikawa, K., Murakami, Y., Hisatomi, T., Enaida, H., & Ishibashi, T. (2013) · Ophthalmology · doi:10.1016/j.ophtha.2012.07.006 · Cited by 262
Self-citationProteomic analysis of human vitreous humor
Murthy, K. R., Goel, R., Subbannayya, Y., Jacob, H. K., Murthy, P. R., Manda, S. S., Patil, A. H., Sharma, R., Sahasrabuddhe, N. A., Parashar, A., et al. (2014) · Clinical Proteomics · doi:10.1186/1559-0275-11-29 · Cited by 145
Innate Immune Response in Retinal Homeostasis and Inflammatory Disorders
Murakami, Y., Ishikawa, K., Nakao, S., & Sonoda, K.-H. (2020) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2019.100778 · Cited by 125
Self-citationHu, D.-N., Bi, M., Zhang, D. Y., Ye, F., McCormick, S. A., & Chan, C.-C. (2014) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.14-14685 · Cited by 36
Dissection of Human Vitreous Body Elements for Proteomic Analysis
Skeie, J. M., & Mahajan, V. B. (2011) · Journal of Visualized Experiments · doi:10.3791/2455 · Cited by 28
Metadata
- Authors
- Yoshimura, T., Sonoda, K.-H., Sugahara, M., Mochizuki, Y., Enaida, H., Oshima, Y., Ueno, A., Hata, Y., Yoshida, H., & Ishibashi, T.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2009-12-04
- Volume
- 4
- Issue
- 12
- Pages
- e8158
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W1978726594
- Cited by
- 342
- References
- 48
- FWCI
- 15.21
- Type
- journal article
- Language
- en
- Open access
- gold
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- Yoshimura, T., Sonoda, K.-H., Sugahara, M., Mochizuki, Y., Enaida, H., Oshima, Y., Ueno, A., Hata, Y., Yoshida, H., & Ishibashi, T. (2009). Comprehensive Analysis of Inflammatory Immune Mediators in Vitreoretinal Diseases. PLoS ONE. https://doi.org/10.1371/journal.pone.0008158
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