Innate Immune Response in Retinal Homeostasis and Inflammatory Disorders

A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease

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Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

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Macrophages in Tissue Repair, Regeneration, and Fibrosis

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Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

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ATP mediates rapid microglial response to local brain injury in vivo

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HMG-1 as a Late Mediator of Endotoxin Lethality in Mice

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The Classical Complement Cascade Mediates CNS Synapse Elimination

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The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

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Macrophages in the Pathogenesis of Atherosclerosis

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Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

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Chemokines

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The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

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Evolution of the immune system in humans from infancy to old age

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Myeloid-derived suppressor cells coming of age

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Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases

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Macrophages: master regulators of inflammation and fibrosis

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A central role for inflammation in the pathogenesis of diabetic retinopathy

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Reversing established sepsis with antagonists of endogenous high-mobility group box 1

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Inflammation in diabetic retinopathy

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Molecular Imaging in Cancer

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Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected

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Seven-Year Outcomes in Ranibizumab-Treated Patients in ANCHOR, MARINA, and HORIZON

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High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease

Mrdjen, D., Pavlovic, A., Hartmann, F. J., Schreiner, B., Utz, S. G., Leung, B. P., Lelios, I., Heppner, F. L., Kipnis, J., Merkler, D., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.01.011 · Cited by 1,010 · see citing works

CARD15 mutations in Blau syndrome

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Origin and differentiation of microglia

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P2X receptors as cell-surface ATP sensors in health and disease

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Ocular immune privilege: therapeutic opportunities from an experiment of nature

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Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition

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The morphology of various types of cell death in prenatal tissues

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The physiology of the lymphatic system

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The pivotal role of the complement system in aging and age-related macular degeneration: Hypothesis re-visited

Anderson, D. H., Radeke, M. J., Gallo, N. B., Chapin, E. A., Johnson, P. T., Curletti, C. R., Hancox, L. S., Hu, J., Ebright, J. N., Malek, G., et al. (2010) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2009.11.003 · Cited by 727 · see citing works

Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System

Bruttger, J., Karram, K., Wörtge, S., Regen, T., Marini, F., Hoppmann, N., Klein, M., Blank, T., Yona, S., Wolf, Y., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.06.012 · Cited by 634 · see citing works

Live to die another way: modes of programmed cell death and the signals emanating from dying cells

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DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration

Kaneko, H., Dridi, S., Tarallo, V., Gelfand, B. D., Fowler, B. J., Cho, W. G., Kleinman, M. E., Ponicsan, S. L., Hauswirth, W. W., Chiodo, V. A., et al. (2011) · Nature · doi:10.1038/nature09830 · Cited by 601 · see citing works

DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88

Tarallo, V., Hirano, Y., Gelfand, B. D., Dridi, S., Kerur, N., Kim, Y., Cho, W. G., Kaneko, H., Fowler, B. J., Bogdanovich, S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.036 · Cited by 592 · see citing works

RIP Kinase-Dependent Necrosis Drives Lethal Systemic Inflammatory Response Syndrome

Duprez, L., Takahashi, N., Hauwermeiren, F. V., Vandendriessche, B., Goossens, V., Berghe, T. V., Declercq, W., Libert, C., Cauwels, A., & Vandenabeele, P. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.020 · Cited by 591 · see citing works

Immunology of age-related macular degeneration

Ambati, J., Atkinson, J. P., & Gelfand, B. D. (2013) · Nature reviews. Immunology · doi:10.1038/nri3459 · Cited by 591 · see citing works

Activated microglia in human retinitis pigmentosa, late-onset retinal degeneration, and age-related macular degeneration

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Retinal microglia: Just bystander or target for therapy?

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Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci

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Macrophage Depletion Inhibits Experimental Choroidal Neovascularization

Sakurai, E., Anand, A., Ambati, B. K., van Rooijen, N., & Ambati, J. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.03-0097 · Cited by 498 · see citing works

Activated monocytes and granulocytes, capillary nonperfusion, and neovascularization in diabetic retinopathy.

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Liver-Resident Macrophage Necroptosis Orchestrates Type 1 Microbicidal Inflammation and Type-2-Mediated Tissue Repair during Bacterial Infection

Blériot, C., Dupuis, T., Jouvion, G., Eberl, G., Disson, O., & Lecuit, M. (2015) · Immunity · doi:10.1016/j.immuni.2014.12.020 · Cited by 471 · see citing works

Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration

Zhao, L., Zabel, M. K., Wang, X., Ma, W., Shah, P., Fariss, R. N., Qian, H., Parkhurst, C. N., Gan, W., & Wong, W. T. (2015) · EMBO Molecular Medicine · doi:10.15252/emmm.201505298 · Cited by 451 · see citing works

Microglial Function Is Distinct in Different Anatomical Locations during Retinal Homeostasis and Degeneration

O’Koren, E. G., Yu, C., Klingeborn, M., Wong, A. Y. W., Prigge, C. L., Mathew, R., Kalnitsky, J., Msallam, R. A., Silvin, A., Kay, J. N., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.02.007 · Cited by 440 · see citing works

Innate immunity in vertebrates: an overview

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Optical Coherence Tomographic Hyperreflective Foci

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VEGF164-mediated Inflammation Is Required for Pathological, but Not Physiological, Ischemia-induced Retinal Neovascularization

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NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components

Doyle, S., Campbell, M., Ozaki, E., Salomon, R. G., Mori, A., Kenna, P. F., Farrar, G. J., Kiang, A., Humphries, M. M., Lavelle, E. C., et al. (2012) · Nature Medicine · doi:10.1038/nm.2717 · Cited by 418 · see citing works

Macrophage Depletion Diminishes Lesion Size and Severity in Experimental Choroidal Neovascularization

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Müller Cell-Derived VEGF Is Essential for Diabetes-Induced Retinal Inflammation and Vascular Leakage

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The potential angiogenic role of macrophages in the formation of choroidal neovascular membranes.

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Periostin promotes chronic allergic inflammation in response to Th2 cytokines

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InflammasomesPreprint

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Cd1-Reactive Natural Killer T Cells Are Required for Development of Systemic Tolerance through an Immune-Privileged Site

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Inflammation-associated S100 proteins: new mechanisms that regulate function

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Comprehensive Analysis of Inflammatory Immune Mediators in Vitreoretinal Diseases

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Is diabetic retinopathy an inflammatory disease?

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Microglia-Derived Nerve Growth Factor Causes Cell Death in the Developing Retina

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Risk of Scar in the Comparison of Age-related Macular Degeneration Treatments Trials

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Myeloid Cells in the Central Nervous System

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Receptor interacting protein kinases mediate retinal detachment-induced photoreceptor necrosis and compensate for inhibition of apoptosis

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Aqueous humor levels of cytokines are related to vitreous levels and progression of diabetic retinopathy in diabetic patients

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Immune Regulation in the Aging Retina

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Fibrosis and diseases of the eye

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Inhibition of Caspase-1/Interleukin-1β Signaling Prevents Degeneration of Retinal Capillaries in Diabetes and Galactosemia

Vincent, J. A., & Mohr, S. (2006) · Diabetes · doi:10.2337/db06-0427 · Cited by 298 · see citing works

A Pilot Study of Multiple Intravitreal Injections of Ranibizumab in Patients with Center-Involving Clinically Significant Diabetic Macular Edema

Chun, D. W., Heier, J. S., Topping, T. M., Duker, J. S., & Bankert, J. M. (2006) · Ophthalmology · doi:10.1016/j.ophtha.2006.04.033 · Cited by 294 · see citing works

Infiltration of COX-2–expressing macrophages is a prerequisite for IL-1β–induced neovascularization and tumor growth

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cGAS drives noncanonical-inflammasome activation in age-related macular degeneration

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DAMPs as mediators of sterile inflammation in aging-related pathologies

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Ocular Anti-VEGF Therapy for Diabetic Retinopathy: The Role of VEGF in the Pathogenesis of Diabetic Retinopathy

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The critical role of ocular-infiltrating macrophages in the development of choroidal neovascularization

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Association Between Hyperreflective Foci in the Outer Retina, Status of Photoreceptor Layer, and Visual Acuity in Diabetic Macular Edema

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Adaptive optics imaging of the human retina

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Clinical evidence of sustained chronic inflammatory reaction in retinitis pigmentosa

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Suppression of Microglial Activation Is Neuroprotective in a Mouse Model of Human Retinitis Pigmentosa

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Cutting Edge: Role of Macrophage Migration Inhibitory Factor in Inhibiting NK Cell Activity and Preserving Immune Privilege

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Macrophages inhibit neovascularization in a murine model of age-related macular degeneration

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Senescence regulates macrophage activation and angiogenic fate at sites of tissue injury in mice

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Chemokine Mediated Monocyte Trafficking into the Retina: Role of Inflammation in Alteration of the Blood-Retinal Barrier in Diabetic Retinopathy

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NK T Cell-Derived IL-10 Is Essential for the Differentiation of Antigen-Specific T Regulatory Cells in Systemic Tolerance

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Molecular mechanisms of subretinal fibrosis in age-related macular degeneration

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Bruch's membrane and choroidal macrophages in early and advanced age-related macular degeneration

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Pathologic Features of Surgically Excised Subretinal Neovascular Membranes in Age-related Macular Degeneration

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Role of interleukin-1 in the pathogenesis of diabetic retinopathy

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Fate mapping reveals that microglia and recruited monocyte-derived macrophages are definitively distinguishable by phenotype in the retina

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Anterior chamber associated immune deviation (ACAID): regulation, biological relevance, and implications for therapy

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Macrophage polarization in the maculae of age‐related macular degeneration: A pilot study

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Histological and ultrastructural investigation of retinal microaneurysm development in diabetic patients.

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