Progression of Parkinson's Disease Pathology Is Reproduced by Intragastric Administration of Rotenone in Mice

α-Synuclein in Lewy bodies

Spillantini, M. G., Schmidt, M. L., Lee, V. M.-Y., Trojanowski, J. Q., Jakes, R., & Goedert, M. (1997) · Nature · doi:10.1038/42166 · Cited by 8,382

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., et al. (1997) · Science · doi:10.1126/science.276.5321.2045 · Cited by 8,240

The functional anatomy of basal ganglia disorders

Albin, R. L., Young, A. B., & Penney, J. B. (1989) · Trends in Neurosciences · doi:10.1016/0166-2236(89)90074-x · Cited by 5,353

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y., & Shimizu, N. (1998) · Nature · doi:10.1038/33416 · Cited by 5,227

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

Betarbet, R. S., Sherer, T., MacKenzie, G. M., Garcia‐Osuna, M., Panov, A. V., & Greenamyre, J. T. (2000) · Nature Neuroscience · doi:10.1038/81834 · Cited by 3,770

Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator

West, M. J., Slomianka, L., & Gundersen, H. J. G. (1991) · The Anatomical Record · doi:10.1002/ar.1092310411 · Cited by 2,994

Some new, simple and efficient stereological methods and their use in pathological research and diagnosis.

GUNDERSEN, H. J. G., BENDTSEN, T. F., KORBO, L., MARCUSSEN, N., MØLLER, A., NIELSEN, K., NYENGAARD, J. R., PAKKENBERG, B., SØRENSEN, F. B., VESTERBY, A., et al. (1988) · APMIS · doi:10.1111/j.1699-0463.1988.tb05320.x · Cited by 2,929

Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease

Paisán‐Ruiz, C., Jain, S., Evans, E. W., Gilks, W. P., Simón, J., van der Brug, M., de Munaín, A. L., Aparicio, S. F., Gil, A. M., Khan, N. L., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.10.023 · Cited by 2,453

α-Synuclein is phosphorylated in synucleinopathy lesions

Fujiwara, H., Hasegawa, M., Dohmae, N., Kawashima, A., Masliah, E., Goldberg, M. S., Shen, J., Takio, K., & Iwatsubo, T. (2002) · Nature Cell Biology · doi:10.1038/ncb748 · Cited by 2,174

Oxidative stress in Parkinson's disease

Jenner, P. (2003) · Annals of Neurology · doi:10.1002/ana.10483 · Cited by 2,053

Mitochondrial complex I defects increase ubiquitin in substantia nigra

Song, L., & Cortopassi, G. A. (2014) · Brain Research · doi:10.1016/j.brainres.2014.11.013 · Cited by 18

Progressive loss of nigrostriatal dopaminergic neurons induced by inflammatory responses to fipronil

Park, J. H., Park, Y. S., & Koh, H. C. (2016) · Toxicology Letters · doi:10.1016/j.toxlet.2016.06.011 · Cited by 18

A novel treatment strategy to prevent Parkinson’s disease: focus on iron regulatory protein 1 (IRP1)

Berry, T. M., & Moustafa, A. A. (2021) · International Journal of Neuroscience · doi:10.1080/00207454.2021.1885403 · Cited by 17

Aqueous extract of tomato seeds attenuates rotenone‐induced oxidative stress and neurotoxicity in Drosophila melanogaster

Krishna, G., & ., M. (2015) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.7281 · Cited by 18

Effects of reduced mitochondrial DNA content on secondary mitochondrial toxicant exposure in Caenorhabditis elegans

Luz, A. L., & Meyer, J. N. (2016) · Mitochondrion · doi:10.1016/j.mito.2016.08.014 · Cited by 20

Rotenone and elevated extracellular potassium concentration induce cell‐specific fibrillation of α‐synuclein in axons of cholinergic enteric neurons in the guinea‐pig ileum

Sharrad, D. F., Chen, B. N., Gai, W., Vaikath, N. N., El‐Agnaf, O. M. A., & Brookes, S. J. (2016) · Neurogastroenterology & Motility · doi:10.1111/nmo.12985 · Cited by 16

Application of neurotoxin- and pesticide-induced animal models of Parkinson’s disease in the evaluation of new drug delivery systems

Casanova, Y., Negro, S., & Barcia, E. (2021) · Acta Pharmaceutica · doi:10.2478/acph-2022-0008 · Cited by 17

Improving the detection specificity of endogenous MRI for reactive oxygen species (ROS)

Tain, R., Scotti, A., & Cai, K. (2019) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.26629 · Cited by 17

Effect of Rotenone on the Neurodegeneration among Different Models

Subhan, I., & Siddique, Y. H. (2024) · Current Drug Targets · doi:10.2174/0113894501281496231226070459 · Cited by 17

α-Synuclein in Parkinson’s Disease: Does a Prion-Like Mechanism of Propagation from Periphery to the Brain Play a Role?

Zheng, H., Shi, C., Luo, H., Fan, L., Yang, Z., Hu, X., Zhang, Z., Zhang, S., Hu, Z., Fan, Y., et al. (2020) · The Neuroscientist · doi:10.1177/1073858420943180 · Cited by 21

Cognitive deficits in animal models of basal ganglia disorders

Brooks, S. P., & Dunnett, S. B. (2012) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2012.04.011 · Cited by 16

Diffusion kurtosis imaging detects the time‐dependent progress of pathological changes in the oral rotenone mouse model of Parkinson's disease

Khairnar, A., Kučerová, J., Arab, A., Hadjistyllis, C., Minsterová, A. Š., Shang, Q., Chovsepian, A., Dražanová, E., Szabó, N., Starčuk, Z., et al. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15449 · Cited by 15

Prion-like propagation of α-synuclein in the gut-brain axis

Chen, Y., Shao, Q.-H., Yuan, Y., & Chen, N. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.06.002 · Cited by 15

Niacin for Parkinson's disease

Seamon, M., Purohit, S. B., Giri, B., Baban, B., Morgan, J. C., Chong, R. K. Y., & Wakade, C. G. (2019) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12553 · Cited by 16

Time Course of Neurobehavioral Disruptions and Regional Brain Metabolism Changes in the Rotenone Mice Model of Parkinson’s Disease

Troshev, D. V., Воронков, Д. Н., Pavlova, A., Абаимов, Д. А., Латанов, А. В., Федорова, Т. Н., & Berezhnoy, D. S. (2022) · Biomedicines · doi:10.3390/biomedicines10020466 · Cited by 14

New olfactometric findings in Parkinson's disease

Passàli, G. C., Bove, F., Vargiu, L., Bentivoglio, A. R., Anzivino, R., Corso, E. D., Galli, J., Rigante, M., Pandolfini, M., Sergi, B., et al. (2016) · Clinical Otolaryngology · doi:10.1111/coa.12816 · Cited by 15

Systematic literature review on Parkinson's disease and Childhood Leukaemia and mode of actions for pesticides

Choi, J., Polcher, A. A., & Joas, A. (2016) · EFSA Supporting Publications · doi:10.2903/sp.efsa.2016.en-955 · Cited by 18

Synucleinopathies and Tauopathies

Goedert, M., & Spillantini, M. G. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-374947-5.00047-x · Cited by 15

PET Imaging of the Adenosine A2A Receptor in the Rotenone-Based Mouse Model of Parkinson’s Disease with [18F]FESCH Synthesized by a Simplified Two-Step One-Pot Radiolabeling Strategy

Schröder, S., Lai, T. H., Toussaint, M., Kranz, M., Chovsepian, A., Shang, Q., Dukić-Stefanović, S., Deuther‐Conrad, W., Teodoro, R., Wenzel, B., et al. (2020) · Molecules · doi:10.3390/molecules25071633 · Cited by 14

Studies on Parkinson’s-Disease-Linked Genes, Brain Urea Levels and Histopathology in Rotenone Induced Parkinson’s Disease Rat Model

Kavuri, S., Sivanesan, S., Howell, M. D., Vijayaraghavan, R., & Rajadas, J. (2020) · World Journal of Neuroscience · doi:10.4236/wjns.2020.104021 · Cited by 15

Paradoxical lower sensitivity of Locus Coeruleus than Substantia Nigra pars compacta neurons to acute actions of rotenone

Yee, A. G., Freestone, P. S., Bai, J., & Lipski, J. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.10.010 · Cited by 13

The Association Between REM Sleep Behavior Disorder and Autonomic Dysfunction in Parkinson’s Disease

Ashraf‐Ganjouei, A., Moradi, K., Aarabi, M. H., Abdolalizadeh, A., Kazemi, S. Z., Kasaeian, A., & Vahabi, Z. (2021) · Journal of Parkinson s Disease · doi:10.3233/jpd-202134 · Cited by 13

Progesterone: A Neuroprotective Steroid of the Intestine

Stegemann, L. N., Neufeld, P. M., Hecking, I., Vorgerd, M., Matschke, V., Stahlke, S., & Theiß, C. (2023) · Cells · doi:10.3390/cells12081206 · Cited by 12

Etiology and Pathogenesis of Parkinson Disease

deSouza, R., & Schapira, A. H. V. (2017) · Neurodegeneration · doi:10.1002/9781118661895.ch5 · Cited by 13

Tolperisone hydrochloride improves motor functions in Parkinson’s disease via MMP-9 inhibition and by downregulating p38 MAPK and ERK1/2 signaling cascade

Zaman, B., Mostafa, I., Hassan, T., Ahmed, S., Esha, N. J. I., Chowdhury, F. A., Bosu, T., Chowdhury, H. N., Mallick, A., Islam, M. S., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116438 · Cited by 12

Impact of environmental toxicants exposure on gut-brain axis in Parkinson disease

Olubodun-Obadun, T. G., Ishola, I. O., & Adeyemi, O. O. (2022) · Drug Metabolism and Personalized Therapy · doi:10.1515/dmpt-2021-0144 · Cited by 13

Role of the gut-microbiota-metabolite axis in the rotenone model of early-stage Parkinson's Disease

Yan, Z., Li, R., Shi, W., & Yao, L. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-022-01004-6 · Cited by 14

Animal Models of Gastrointestinal Problems in Parkinson's Disease

Greene, J. G. (2011) · Journal of Parkinson s Disease · doi:10.3233/jpd-2011-11033 · Cited by 13

Embelin and levodopa combination therapy for improved Parkinson’s disease treatment

Ramachandra, V. H., Sivanesan, S., Koppal, A., Anandakumar, S., Howell, M. D., Sukumar, E., & Vijayaraghavan, R. (2022) · Translational Neuroscience · doi:10.1515/tnsci-2022-0224 · Cited by 12

Selecting the Best Animal Model of Parkinson’s Disease for Your Research Purpose: Insight from in vivo PET Imaging Studies

Real, C. C., Binda, K. H., Thomsen, M. B., Lillethorup, T. P., Brooks, D. J., & Landau, A. M. (2023) · Current Neuropharmacology · doi:10.2174/1570159x21666230216101659 · Cited by 11

Chronic and acute exposure to rotenone reveals distinct Parkinson's disease-related phenotypes in human iPSC-derived peripheral neurons

Saleh, M. A., Amer‐Sarsour, F., Berant, A., Pasmanik‐Chor, M., Kobo, H., Sharabi, Y., Vatine, G. D., & Ashkenazi, A. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.01.016 · Cited by 11

Animal Models for the Study of Human Neurodegenerative Diseases

Colpo, G. D., Ribeiro, F. M., Rocha, N. P., & Teixeira, A. L. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809468-6.00042-5 · Cited by 12

Tracking micro-optical resonances for identifying and sensing novel procaspase-3 protein marker released from cell cultures in response to toxins

Chen, Y.-J., Xiang, W., Klucken, J., & Vollmer, F. (2016) · Nanotechnology · doi:10.1088/0957-4484/27/16/164001 · Cited by 10

Rotenone Analysis by Liquid Chromatography–Tandem Mass Spectrometry with Information-Dependent Acquisition in a Fatal Case of Rotenone Poisoning with a Commercial Organic Insecticide Being Sold in Korea

Rhee, J., Yum, H., Moon, S., In, S., Lee, S., & Seo, J. (2016) · Journal of Analytical Toxicology · doi:10.1093/jat/bkw032 · Cited by 10

An update on the recognition and treatment of autonomic symptoms in Parkinson’s disease

Jost, W. H. (2017) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2017.1345307 · Cited by 10

The antioxidant Rutin counteracts the pathological impact of α-synuclein on the enteric nervous system in vitro

Christmann, A., Gries, M., Scholz, P., Stahr, P. L., Law, J. K. Y., Schulte, S., Martin, M., Lilischkis, R., Ingebrandt, S., Keck, C. M., et al. (2021) · Biological Chemistry · doi:10.1515/hsz-2021-0259 · Cited by 11

Gastrointestinale Störungen beim idiopathischen Parkinson-Syndrom

Tredici, K. D., & Jost, W. H. (2012) · Der Nervenarzt · doi:10.1007/s00115-012-3575-9 · Cited by 11

Transgenic supplementation of SIRT1 fails to alleviate acute loss of nigrostriatal dopamine neurons and gliosis in a mouse model of MPTP-induced parkinsonism

Kitao, Y., Ageta‐Ishihara, N., Takahashi, R., Kinoshita, M., & Hori, O. (2015) · F1000Research · doi:10.12688/f1000research.6386.1 · Cited by 10

Autophagy-related protein expression in the substantia nigra and eldepryl intervention in rat models of Parkinson׳s disease

Liu, B., Sun, J., Zhang, J., Mao, W., Ma, Y., Li, S., Cheng, X., & Lv, C. (2015) · Brain Research · doi:10.1016/j.brainres.2015.08.033 · Cited by 12

Impact of age on the rotenone-induced sporadic Parkinson's disease model using Drosophila melanogaster

Li, W., Pan, X., Li, M., Li, L., Zhang, M., liu, Z., Zhang, K., Guo, J., & Wang, H. (2023) · Neuroscience Letters · doi:10.1016/j.neulet.2023.137187 · Cited by 9

Parkinson's Disease and Mitotherapy-Based Approaches towards α-Synucleinopathies

Bhatt, V., Shukla, H., & Tiwari, A. K. (2024) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2306109 · Cited by 9

Hyperglycemia-Driven Insulin Signaling Defects Promote Parkinson’s Disease-like Pathology in Mice

Soni, R., Mathur, K., Rathod, H., Khairnar, A., & Shah, J. (2024) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.4c00586 · Cited by 9

Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein

Dening, Y., Straßl, T., Ruf, V., Dirscherl, P., Chovsepian, A., Stiévenard, A., Khairnar, A., Schmidt, F., Giesert, F., Herms, J. W., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-25790-2 · Cited by 9

Parkinson’s disease. Focus on early stages

Катунина, Е. А., Zalyalova, Z. A., Похабов, Д. В., Ivanova, M. Z. I., & Semenova, A. M. (2023) · Neurology neuropsychiatry Psychosomatics · doi:10.14412/2074-2711-2023-3-95-103 · Cited by 12

Body-first Parkinson’s disease and variant Creutzfeldt–Jakob disease – similar or different?

Woerman, A. L., & Tamgüney, G. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105625 · Cited by 8

In Vivo Study of Moringa oleifera Seed Extracts as Potential Sources of Neuroprotection against Rotenone-Induced Neurotoxicity

Raza, C., MOHSIN, S., Faheem, M., Hanif, U., Alkhathlan, H. Z., Shaik, M. R., Riaz, H. A., Anjum, R., Jurrat, H., & Khan, M. (2024) · Plants · doi:10.3390/plants13111479 · Cited by 8

Autophagy and Cell Death in Alzheimer’s, Parkinson’s and Prion Diseases

Ribarič, S., & Ribarič, I. M. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.86706 · Cited by 9

Food Contamination: An Unexplored Possible Link between Dietary Habits and Parkinson’s Disease

Caioni, G., Cimini, A., & Benedetti, E. (2022) · Nutrients · doi:10.3390/nu14071467 · Cited by 9

Disease mechanisms as subtypes: Microbiome

Bonvegna, S., & Cilia, R. (2023) · Handbook of clinical neurology · doi:10.1016/b978-0-323-85555-6.00006-0 · Cited by 8

Etiology and Pathogenesis of Parkinson’s Disease

Timpka, J., Cenci, M. A., & Odin, P. (2017) · Springer eBooks · doi:10.1007/978-3-7091-1628-9_10 · Cited by 8

Glial cells modulate retinal cell survival in rotenone-induced neural degeneration

Tawarayama, H., Inoue-Yanagimachi, M., Himori, N., & Nakazawa, T. (2021) · Scientific Reports · doi:10.1038/s41598-021-90604-w · Cited by 9

Nutrition and Gastrointestinal Health as Modulators of Parkinson’s Disease

Rasmussen, H. E., Piazza, B., Forsyth, C. B., & Keshavarzian, A. (2014) · AAPS advances in the pharmaceutical sciences series · doi:10.1007/978-3-319-06151-1_11 · Cited by 9

Blood α-synuclein in agricultural pesticide handlers in central Washington State

Nielsen, S. S., Checkoway, H., Zhang, J., Hofmann, J. N., Keifer, M., Paulsen, M., Farin, F. M., Cook, T. J., & Simpson, C. D. (2014) · Environmental Research · doi:10.1016/j.envres.2014.10.014 · Cited by 8

Pesticides and Parkinson’s Disease

Arthur, G., & Jeff, M. (2011) · InTech eBooks · doi:10.5772/16479 · Cited by 8

FLIM Analysis of Intracellular Markers Associated With the Development of Parkinson's Disease in Cellular Model

Pokusa, M., & Trancikova, A. K. (2018) · Physiological Research · doi:10.33549/physiolres.934054 · Cited by 7

Targeting the Gut–Brain Axis with Fecal Microbiota Transplantation: Considerations on a Potential Novel Treatment for Parkinson's Disease

Contarino, M. F., van Hilten, J. J., & Kuijper, E. J. (2022) · Movement Disorders Clinical Practice · doi:10.1002/mdc3.13621 · Cited by 7

Experimental models of gut‐first Parkinson's disease: A systematic review

Videlock, E. J., Xing, T., Yehya, A. H. S., & Travagli, R. A. (2023) · Neurogastroenterology & Motility · doi:10.1111/nmo.14604 · Cited by 9

Inorganic mercury within motor neurons does not cause the TDP-43 changes seen in sporadic ALS

Pamphlett, R., & Jew, S. K. (2010) · Toxicology Letters · doi:10.1016/j.toxlet.2010.12.005 · Cited by 7

Rotenone Use in Fish Management and Parkinson's Disease: Another Look

Finlayson, B. J., Schnick, R. A., Skaar, D., Anderson, J. D., DeMong, L., Duffield, D., Horton, W., Steinkjer, J., & VanMaaren, C. (2012) · Fisheries · doi:10.1080/03632415.2012.723963 · Cited by 7

Characterization of the Basic Membrane Properties of Neurons of the Rat Dorsal Motor Nucleus of the Vagus in Paraquat-Induced Models of Parkinsonism

Bove, C., Coleman, F. H., & Travagli, R. A. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.08.048 · Cited by 7

RNA-Seq Expression Analysis of Enteric Neuron Cells with Rotenone Treatment and Prediction of Regulated Pathways

Guan, Q., Wang, X., Jiang, Y., Zhao, L., Nie, Z., & Jin, L. (2016) · Neurochemical Research · doi:10.1007/s11064-016-2112-9 · Cited by 8

No Evidence of Sensory Neuropathy in a Traditional Mouse Model of Idiopathic Parkinson’s Disease

Faisal, M., Rusetskaya, A., Väli, L., Taba, P., Minajeva, A., & Hickey, M. A. (2024) · Cells · doi:10.3390/cells13100799 · Cited by 6

Using selective insecticides in sustainable IPM.

Hardy, M. C. (2012) · CABI Reviews · doi:10.1079/pavsnnr20116039 · Cited by 6

Downregulation of Pael-R expression in a Parkinson’s disease cell model reduces apoptosis

Zou, T., Xiao, B., Tang, J., Zhang, H., & Tang, X. (2012) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2011.12.024 · Cited by 6

Age-dependent aggregation of α-synuclein in the nervous system of gut-brain axis is associated with caspase-1 activation

Hu, Q. Z., Hong, M., Huang, M., Gong, Q., Zhang, X., Uversky, V. N., Pan-Montojo, F. J., Huang, T., Zhou, H., & Zhu, S. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-022-00917-6 · Cited by 7

Etiology and Progression of Parkinson's Disease: Cross-Talk Between Environmental Factors and Genetic Vulnerability

Fernagut, P. (2016) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-802206-1.00040-4 · Cited by 8

From blood vessels to brain cells: Connecting the circulatory system and Parkinson's disease

Olaoye, O. J., Farrow, S. L., Nyaga, D. M., Cooper, A. A., & O'Sullivan, J. M. (2025) · Journal of Parkinson s Disease · doi:10.1177/1877718x241308168 · Cited by 6

Rotenone aggravates PD-like pathology in A53T mutant human α-synuclein transgenic mice in an age-dependent manner

Chen, A.-D., Cao, J., Chen, H., Du, H., Xi, X.-X., Sun, J., Yin, J., Jing, Y., & Gao, L. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.842380 · Cited by 5

Colonic Myenteric Plexus Neurodegeneration and Minor Colon Inflammation in Trimethyltin-induced Rat Model of Neurodegeneration

Septyaningtrias, D. E., Zulfa, H. A., Ramadhani, M. F., Sumaryati, Sulistyawati, D., Paramita, D. K., Sumiwi, Y. A. A., & Susilowati, R. (2023) · Journal of Histochemistry & Cytochemistry · doi:10.1369/00221554231182195 · Cited by 5

Parkinson’s disease and metabolic disorders, understanding their shared co-morbidity through the autonomic nervous system

Pham, T., Schelling, R. E., & Loh, K. H. (2025) · Advances in genetics · doi:10.1016/bs.adgen.2025.02.001 · Cited by 5

Rotenone as Preclinical Model Compound in Parkinson Disease

Cannon, J. R., & Greenamyre, J. T. (2014) · Springer eBooks · doi:10.1007/978-1-4614-5836-4_8 · Cited by 5

Neurodegeneration in a regulatory context: The need for speed

Meerman, J. J., Wolterink, G., Hessel, E. V. S., de Jong, E., & Heusinkveld, H. J. (2022) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2022.100383 · Cited by 5

Benzoic-D5 acid as D2 receptor agonist in the treatment of rotenone induced Parkinson’s disease in mice

Zaidi, S. A. A., Khan, M. A., Khan, M. R., Ahmed, H., Shaheryar, Z. A., Sahibzada, M. U. K., Alghamdi, S. A., Aljuaid, A., Almehmadi, M. M., & Allahyani, M. A. (2023) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2023.104982 · Cited by 5

Animal models of synucleinopathies and how they could impact future drug discovery and delivery efforts

Jellinger, K. A. (2019) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2019.1638908 · Cited by 6

From Man to Mouse

Jackson-Lewis, V., Lester, D. B., Kozina, E. A., Przedborski, S., & Smeyne, R. J. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405195-9.00017-2 · Cited by 5

Gut Hormones Restrict Neurodegeneration in Parkinson’s Disease

Bayliss, J. A., Stark, R., Reichenbach, A., & Zane, B. (2011) · InTech eBooks · doi:10.5772/28028 · Cited by 6

Functional and molecular early enteric biomarkers for Parkinson’s disease in mice and menPreprint

Gries, M., Christmann, A., Schulte, S., Weyland, M., Rommel, S., Martin, M., Baller, M. K., Röth, R., Schmitteckert, S., Unger, M. M., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.06.136556 · Cited by 5

Safety and feasibility of fecal microbiota transplantation for Parkinson’s disease patients: a protocol for a self-controlled interventional donor-FMT pilot studyPreprint

Vendrik, K. E. W., Chernova, V. O., Kuijper, E. J., Terveer, E. M., van Hilten, J. J., & Contarino, M. F. (2022) · medRxiv · doi:10.1101/2022.05.23.22274942 · Cited by 5

Chronic DSS-Induced Colitis Exacerbates Parkinson’s Disease Phenotype and Its Pathological Features Following Intragastric Rotenone Exposure

Sharma, N., Sharma, M., Thakkar, D., Kumar, H., Smetanová, S., Burešová, L., Andrla, P., & Khairnar, A. (2025) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.4c00286 · Cited by 4

Female Urinary Retention Progressing to Possible Multiple System Atrophy-cerebellar Form after 12 Years

Sakakibara, R., Sekiguchi, Y., Panicker, J. N., Sekido, N., Sugimoto, H., Sugisaki, Y., Shimizu, A., Takahashi, O., Ogata, T., Sawai, S., et al. (2022) · Internal Medicine · doi:10.2169/internalmedicine.8724-21 · Cited by 4

Interplay of alpha-synuclein pathology and gut microbiome in Parkinson’s disease

Srivastava, A., Kataria, A., Yadav, D. K., Han, I., & Choi, E. H. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91313-3.00003-9 · Cited by 4

Neuroprotective Potential of Polydatin in Combating Parkinson’s Disease through the Inhibition of Monoamine Oxidase-B and Catechol-o-Methyl Transferase

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Animal models of Parkinson’s disease and related disorders

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Interferon-induced surface alterations in hairy cells. A review.

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The Pael-R gene does not mediate the changes in rotenone-induced Parkinson′s disease model cells

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Colonic Oxidative and Mitochondrial Function in Parkinson’s Disease and Idiopathic REM Sleep Behavior Disorder

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Title Progression of Parkinson’s disease pathology is reproduced by intragastric administration of rotenone in mice Authors and Affiliations

Pan-montojo, F., Anichtchik, O. V., Dening, Y., Knels, L., Gille, G., Spillantini, M. G., Reichmann, H., Funk, R. H. W., Fakultät, M., Carus, C. G., et al. (2016)

Oral Administration of Rotenone using a Gavage and Image Analysis of Alpha-synuclein Inclusions in the Enteric Nervous System

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Chronic rotenone exposure reproduces Parkinson's disease gastrointestinal neuropathology

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Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice

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Environment-contact administration of rotenone: A new rodent model of Parkinson’s disease

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