The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
The Impact of Obstructive Sleep Apnea on Metabolic and Inflammatory Markers in Consecutive Patients with Metabolic Syndrome
Open accessAbstract
BACKGROUND: Obstructive Sleep Apnea (OSA) is tightly linked to some components of Metabolic Syndrome (MetS). However, most of the evidence evaluated individual components of the MetS or patients with a diagnosis of OSA that were referred for sleep studies due to sleep complaints. Therefore, it is not clear whether OSA exacerbates the metabolic abnormalities in a representative sample of patients with MetS. METHODOLOGY/PRINCIPAL FINDINGS: We studied 152 consecutive patients (age 48+/-9 years, body mass index 32.3+/-3.4 Kg/m2) newly diagnosed with MetS (Adult Treatment Panel III). All participants underwent standard polysomnography irrespective of sleep complaints, and laboratory measurements (glucose, lipid profile, uric acid and C-reactive protein). The prevalence of OSA (apnea-hypopnea index>or=15 events per hour of sleep) was 60.5%. Patients with OSA exhibited significantly higher levels of blood pressure, glucose, triglycerides, cholesterol, LDL, cholesterol/HDL ratio, triglycerides/HDL ratio, uric acid and C-reactive protein than patients without OSA. OSA was independently associated with 2 MetS criteria: triglycerides: OR: 3.26 (1.47-7.21) and glucose: OR: 2.31 (1.12-4.80). OSA was also independently associated with increased cholesterol/HDL ratio: OR: 2.38 (1.08-5.24), uric acid: OR: 4.19 (1.70-10.35) and C-reactive protein: OR: 6.10 (2.64-14.11). Indices of sleep apnea severity, apnea-hypopnea index and minimum oxygen saturation, were independently associated with increased levels of triglycerides, glucose as well as cholesterol/HDL ratio, uric acid and C-reactive protein. Excessive daytime sleepiness had no effect on the metabolic and inflammatory parameters. CONCLUSIONS/SIGNIFICANCE: Unrecognized OSA is common in consecutive patients with MetS. OSA may contribute to metabolic dysregulation and systemic inflammation in patients with MetS, regardless of symptoms of daytime sleepiness.
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Cites
A New Method for Measuring Daytime Sleepiness: The Epworth Sleepiness Scale
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Chobanian, A. V., Bakris, G. L., Black, H. R., Cushman, W. C., Green, L. A., Izzo, J. L., Jones, D. W., Materson, B. J., Oparil, S., Wright, J. T., et al. (2003) · Hypertension · doi:10.1161/01.hyp.0000107251.49515.c2 · Cited by 13,271
Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.169404 · Cited by 11,961
Prospective Study of the Association between Sleep-Disordered Breathing and Hypertension
Peppard, P. E., Young, T., Palta, M., & Skatrud, J. (2000) · New England Journal of Medicine · doi:10.1056/nejm200005113421901 · Cited by 4,973
Cardiovascular Morbidity and Mortality Associated With the Metabolic Syndrome
Isomaa, B., Almgren, P., Tuomi, T., Forsén, B., Lahti, K., Nissén, M., Taskinen, M.-R., & Groop, L. (2001) · Diabetes Care · doi:10.2337/diacare.24.4.683 · Cited by 4,760
Epidemiology of Obstructive Sleep Apnea: A Population Health Perspective
Young, T., Peppard, P. E., & Gottlieb, D. J. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2109080 · Cited by 4,244
Metabolic Syndrome and Risk of Incident Cardiovascular Events and Death
Gami, A. S., Witt, B. J., Howard, D. E., Erwin, P. J., Gami, L. A., Somers, V. K., & Montori, V. M. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.09.032 · Cited by 1,888
Obstructive Sleep Apnea Among Obese Patients With Type 2 Diabetes
Foster, G. D., Sanders, M. H., Millman, R., Zammit, G., Borradaile, K. E., Newman, A. B., Wadden, T. A., Kelley, D., Wing, R. R., Pi Sunyer, F. X., et al. (2009) · Diabetes Care · doi:10.2337/dc08-1776 · Cited by 600
Cited by
Drager, L. F., Togeiro, S. M., Polotsky, V. Y., & Lorenzi-Filho, G. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.05.045 · Cited by 886
Self-citationSerum Inflammatory Markers in Obstructive Sleep Apnea: A Meta-Analysis
Nadeem, R., Molnar, J., Madbouly, E. M., Nida, M., Aggarwal, S., Sajid, H., Naseem, J., & Loomba, R. (2013) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.3070 · Cited by 481
Drager, L. F., Polotsky, V. Y., & Lorenzi-Filho, G. (2011) · Chest · doi:10.1378/chest.10-2223 · Cited by 322
Self-citationMechanisms of cardiac dysfunction in obstructive sleep apnea
Baguet, J.-P., Barone-Rochette, G., Tamisier, R., Levy, P., & Pépin, J.-L. (2012) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2012.141 · Cited by 275
Intermittent Hypoxia Exacerbates Metabolic Effects of Diet‐Induced Obesity
Drager, L. F., Li, J., Reinke, C., Bevans‐Fonti, S., Jun, J. C., & Polotsky, V. Y. (2011) · Obesity · doi:10.1038/oby.2011.240 · Cited by 208
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Metadata
- Authors
- Drager, L. F., Lopes, H. F., Maki-Nunes, C., Trombetta, I. C., Toschi-Dias, E., Alves, M. J. N. N., Fraga, R. F., Jun, J. C., Negrão, C. E., Krieger, E. M., Polotsky, V. Y., & Lorenzi-Filho, G.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2010-08-11
- Volume
- 5
- Issue
- 8
- Pages
- e12065
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2031750226
- Cited by
- 284
- References
- 9
- FWCI
- 12.36
- Type
- journal article
- Language
- en
- Open access
- gold
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- Drager, L. F., Lopes, H. F., Maki-Nunes, C., Trombetta, I. C., Toschi-Dias, E., Alves, M. J. N. N., Fraga, R. F., Jun, J. C., Negrão, C. E., Krieger, E. M., Polotsky, V. Y., & Lorenzi-Filho, G. (2010). The Impact of Obstructive Sleep Apnea on Metabolic and Inflammatory Markers in Consecutive Patients with Metabolic Syndrome. PLoS ONE. https://doi.org/10.1371/journal.pone.0012065
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