The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Granuloma Formation and Host Defense in Chronic Mycobacterium tuberculosis Infection Requires PYCARD/ASC but Not NLRP3 or Caspase-1
Open accessAbstract
The NLR gene family mediates host immunity to various acute pathogenic stimuli, but its role in chronic infection is not known. This paper addressed the role of NLRP3 (NALP3), its adaptor protein PYCARD (ASC), and caspase-1 during infection with Mycobacterium tuberculosis (Mtb). Mtb infection of macrophages in culture induced IL-1beta secretion, and this requires the inflammasome components PYCARD, caspase-1, and NLRP3. However, in vivo Mtb aerosol infection of Nlrp3(-/-), Casp-1(-/-), and WT mice showed no differences in pulmonary IL-1beta production, bacterial burden, or long-term survival. In contrast, a significant role was observed for Pycard in host protection during chronic Mtb infection, as shown by an abrupt decrease in survival of Pycard(-/-) mice. Decreased survival of Pycard(-/-) animals was associated with defective granuloma formation. These data demonstrate that PYCARD exerts a novel inflammasome-independent role during chronic Mtb infection by containing the bacteria in granulomas.
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Cites
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Cryopyrin activates the inflammasome in response to toxins and ATP
Mariathasan, S., Weiss, D. S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., Lee, W. P., Weinrauch, Y., Monack, D. M., & Dixit, V. M. (2006) · Nature · doi:10.1038/nature04515 · Cited by 3,080
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The PYRIN-CARD Protein ASC Is an Activating Adaptor for Caspase-1
Srinivasula, S. M., Poyet, J.-L., Razmara, M., Datta, P., Zhang, Z., & Alnemri, E. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200179200 · Cited by 573
NLRs at the intersection of cell death and immunity
Ting, J. P.-Y., Willingham, S. B., & Bergstralh, D. T. (2008) · Nature Reviews Immunology · doi:10.1038/nri2296 · Cited by 371 · cited 1×
“In addition to these inflammatory functions, PYCARD association with NLR proteins is required for pyroptotic and pyronecrotic cell death [19,20].”
BackgroundSelf-citationKurtz, S., McKinnon, K. P., Runge, M. S., Ting, J. P.-Y., & Braunstein, M. (2006) · Infection and Immunity · doi:10.1128/iai.01022-06 · Cited by 114
Self-citation
Cited by
Toll-like receptors and their crosstalk with other innate receptors in infection and immunity
Kawai, T., & Akira, S. (2011) · Immunity · doi:10.1016/j.immuni.2011.05.006 · Cited by 3,658
Mishra, B. B., Rathinam, V. A. K., Martens, G. W., Martinot, A. J., Kornfeld, H., Fitzgerald, K. A., & Sassetti, C. M. (2013) · Nature Immunology · doi:10.1038/ni.2474 · Cited by 571
Innate immunity in tuberculosis: host defense vs pathogen evasion
Liu, C. H., Liu, H., & Ge, B. (2017) · Cellular & Molecular Immunology · doi:10.1038/cmi.2017.88 · Cited by 532
Mayer-Barber, K. D., Andrade, B. B., Barber, D. L., Hieny, S., Feng, C. G., Caspar, P., Oland, S., Gordon, S., & Sher, A. (2011) · Immunity · doi:10.1016/j.immuni.2011.12.002 · Cited by 418
Tuberculosis Pathogenesis and Immunity
Philips, J. A., & Ernst, J. D. (2012) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-011811-132458 · Cited by 416
Metadata
- Authors
- McElvania TeKippe, E., Allen, I. C., Hulseberg, P. D., Sullivan, J. T., McCann, J. R., Sandor, M., Braunstein, M., & Ting, J. P.-Y.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2010-08-20
- Volume
- 5
- Issue
- 8
- Pages
- e12320
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2007432455
- Cited by
- 160
- References
- 8
- FWCI
- 11.14
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Granuloma Formation and Host Defense in Chronic Mycobacterium tuberculosis Infection Requires PYCARD/ASC but Not NLRP3 or Caspase-1. https://app.cochat.ai/papers/10.1371/journal.pone.0012320
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- McElvania TeKippe, E., Allen, I. C., Hulseberg, P. D., Sullivan, J. T., McCann, J. R., Sandor, M., Braunstein, M., & Ting, J. P.-Y. (2010). Granuloma Formation and Host Defense in Chronic Mycobacterium tuberculosis Infection Requires PYCARD/ASC but Not NLRP3 or Caspase-1. PLoS ONE. https://doi.org/10.1371/journal.pone.0012320
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